Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   RWA20_RS12060 Genome accession   NZ_CP136119
Coordinates   2565601..2567793 (-) Length   730 a.a.
NCBI ID   WP_005692250.1    Uniprot ID   C2JYT4
Organism   Lacticaseibacillus rhamnosus strain LMG 23550     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 2560601..2572793
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RWA20_RS12040 (RWA20_12040) - 2560821..2561903 (+) 1083 WP_005692258.1 aldo/keto reductase -
  RWA20_RS12045 (RWA20_12045) - 2562203..2563558 (-) 1356 WP_005692255.1 threonine/serine exporter ThrE family protein -
  RWA20_RS12050 (RWA20_12050) - 2563738..2564148 (-) 411 WP_005692253.1 hypothetical protein -
  RWA20_RS12055 (RWA20_12055) - 2564209..2565588 (-) 1380 WP_005692252.1 bacteriocin secretion accessory protein -
  RWA20_RS12060 (RWA20_12060) comA 2565601..2567793 (-) 2193 WP_005692250.1 peptide cleavage/export ABC transporter Regulator
  RWA20_RS12065 (RWA20_12065) - 2568042..2568176 (-) 135 WP_005692249.1 bacteriocin-like peptide, LSEI_2386 family -
  RWA20_RS12070 (RWA20_12070) - 2568352..2569665 (+) 1314 WP_019728291.1 GHKL domain-containing protein -
  RWA20_RS12075 (RWA20_12075) - 2569658..2570434 (+) 777 WP_005692246.1 response regulator transcription factor -
  RWA20_RS12080 (RWA20_12080) - 2570554..2570814 (-) 261 WP_014571574.1 hypothetical protein -
  RWA20_RS12085 (RWA20_12085) - 2572282..2572581 (-) 300 WP_005692238.1 bacteriocin immunity protein -

Sequence

Protein


Download         Length: 730 a.a.        Molecular weight: 81572.82 Da        Isoelectric Point: 7.0674

>NTDB_id=888632 RWA20_RS12060 WP_005692250.1 2565601..2567793(-) (comA) [Lacticaseibacillus rhamnosus strain LMG 23550]
MFKHTPKLGQITYYKRFYTAQVDERDCGVAALNMLLKYNGSDYSLAHLRELAKTNQDGTTALGIVRAAEALAFETKPVQA
DMQLFDLEDVPYPFIAHVLKRGELLHYYVVFKATRTSILIGDPDPSVRMTWLSREVFEKEWSGVAIFIAPAPQYQPRKED
KGSLFAFVPMLAKQKGIIANIILAAVLITVISIVGSYFLQSIIDTYIPNAMRTTMGMIASGLLVAYLLQAVLTYGQNFLM
AVLGQRLAIDVILGYVRHLYELPMSFFSTRRTGEIVSRFADANKIIDALANTIMTLFLDVWIVLILGIVLGIQNGTLFLV
SLIAVPCYLVIVFAFQRPFDRLNQETMESNAILSSSIIEDLNGIETIKSLTGERVSYERVDREFLTYLKRSFSYTKADQL
QQAIKGLLKLALNVVVLWIGASLVIANRMSLGQMLTFNALLSYFTNPLESIINLQPKLQMARVANNRLNEVYLVESEFKE
QRHLTERHLIEGPIRVRDVSFKYGFGQDVLKNINLEVPENAKYTIVGMSGSGKSTLAKLLVGFYPVDADKGTITFNGIPV
KDINLTTLRQYIEYVPQDPFIFSGTVLENLTLGSRSDVSEQDLTQACLAAEIAADIANLPQQWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGKIVEQGDHATLLAQ
DGYYARLVHE

Nucleotide


Download         Length: 2193 bp        

>NTDB_id=888632 RWA20_RS12060 WP_005692250.1 2565601..2567793(-) (comA) [Lacticaseibacillus rhamnosus strain LMG 23550]
ATGTTTAAACACACCCCCAAACTAGGCCAGATCACCTACTACAAACGCTTCTACACCGCACAAGTTGACGAGCGTGACTG
TGGTGTGGCTGCGTTAAACATGCTGCTTAAATACAATGGGTCGGACTATTCGTTAGCCCACCTGCGCGAGTTAGCGAAGA
CAAATCAGGATGGCACGACGGCTTTGGGAATCGTTCGGGCCGCTGAAGCACTAGCGTTTGAGACAAAACCGGTACAGGCG
GATATGCAGTTGTTTGATCTTGAGGATGTGCCTTATCCGTTTATTGCCCATGTGCTGAAGCGCGGTGAATTGCTTCATTA
CTATGTTGTTTTTAAAGCAACGCGCACGAGTATTCTGATTGGCGATCCTGACCCGTCAGTGCGCATGACCTGGCTTTCGC
GAGAGGTGTTTGAAAAAGAATGGTCGGGTGTGGCCATCTTTATTGCACCGGCGCCGCAGTATCAGCCGCGTAAGGAGGAC
AAAGGCAGTTTGTTTGCGTTTGTACCCATGCTGGCTAAGCAAAAAGGTATTATCGCGAACATTATTCTGGCCGCGGTATT
GATTACGGTCATTAGTATCGTTGGGTCGTATTTTTTGCAGTCTATTATTGATACGTATATACCGAATGCCATGCGGACGA
CGATGGGGATGATTGCTAGTGGCCTTTTGGTGGCTTACTTGCTGCAAGCTGTGTTGACTTATGGCCAGAATTTTTTGATG
GCGGTGTTGGGGCAGCGGCTTGCGATTGATGTCATTTTAGGGTATGTGCGCCACTTATATGAATTGCCGATGTCGTTTTT
TTCAACTCGGCGGACCGGAGAGATTGTGTCGCGGTTTGCGGATGCCAATAAAATTATTGACGCGCTGGCGAATACGATTA
TGACGTTGTTTTTGGATGTCTGGATTGTCCTAATATTAGGCATTGTTCTAGGGATCCAAAATGGGACTTTGTTTTTAGTG
TCATTGATTGCCGTGCCGTGTTATTTGGTGATTGTTTTTGCATTTCAGCGGCCGTTTGATCGGTTGAACCAAGAGACGAT
GGAAAGTAACGCAATCTTGAGTTCATCGATTATTGAAGATTTGAATGGCATTGAAACCATCAAGTCCTTGACCGGCGAAC
GAGTTAGCTATGAACGGGTTGATCGGGAATTTCTAACCTATTTGAAGAGGTCGTTTAGTTACACCAAGGCAGATCAGTTA
CAGCAAGCGATTAAAGGCCTGTTGAAGCTGGCGTTGAACGTTGTGGTGTTGTGGATTGGGGCAAGTTTGGTGATTGCCAA
TCGAATGAGTTTGGGGCAGATGCTGACCTTTAATGCGCTGCTGTCATACTTTACGAATCCGCTTGAAAGCATCATCAACC
TACAGCCAAAGTTACAAATGGCGCGGGTTGCTAACAATCGCCTGAATGAAGTTTATCTGGTCGAATCGGAATTCAAAGAA
CAGCGGCACTTGACGGAGCGGCATTTAATCGAAGGTCCGATACGCGTTCGGGATGTCTCGTTTAAATATGGTTTTGGCCA
AGATGTGTTAAAAAACATCAACCTTGAAGTGCCGGAAAATGCTAAATATACCATTGTCGGTATGAGCGGTTCTGGTAAGT
CGACATTAGCAAAATTATTAGTTGGCTTTTACCCGGTTGATGCCGATAAAGGAACCATTACGTTTAATGGCATTCCGGTC
AAAGACATTAACCTGACAACATTACGGCAATATATTGAATATGTACCTCAGGATCCGTTTATTTTTTCGGGCACGGTGTT
GGAGAATTTGACGTTAGGTAGCCGTTCGGATGTTTCGGAACAAGATTTGACGCAGGCGTGTTTGGCTGCGGAAATTGCCG
CAGACATCGCAAACTTACCGCAGCAGTGGCAGACCAAATTGTCAGAAAGCGGCAGCATTTTATCAGGCGGTCAGAAGCAG
CGGCTGGCGATTGCACGGGCCTTGTTGTCACCGGCAAAAGTACTGATTTTTGACGAATCGACCAGCAGTCTGGATACCAT
TACAGAGCGAAAAATTGTCGATCGCTTGCTGGCAATGACGGATCGGACCATTATTTTTGTTGCCCATCGCTTAACTATTG
CGGCTAAAACCGAACAAATTGTGGTGATGGATCATGGCAAAATTGTGGAACAAGGTGACCATGCAACGTTGTTAGCCCAA
GACGGTTATTACGCGCGCCTGGTTCATGAGTGA

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(510-662)

ABC transporter transmembrane region (ABC_membrane)

(180-448)

Peptidase C39 family (Peptidase_C39)

(18-152)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C2JYT4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus pneumoniae D39

58.322

97.945

0.571
  comA Streptococcus pneumoniae R6

58.322

97.945

0.571
  comA Streptococcus pneumoniae Rx1

58.322

97.945

0.571
  comA Streptococcus pneumoniae TIGR4

57.902

97.945

0.567
  comA Streptococcus mitis NCTC 12261

57.902

97.945

0.567
  comA Streptococcus mitis SK321

57.762

97.945

0.566
  comA Streptococcus gordonii str. Challis substr. CH1

56.745

98.493

0.559
  comA/nlmT Streptococcus mutans UA159

53.825

98.493

0.53