Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   RMQ61_RS04630 Genome accession   NZ_CP135090
Coordinates   917403..918074 (+) Length   223 a.a.
NCBI ID   WP_024400692.1    Uniprot ID   A0A3Q8BJ03
Organism   Streptococcus suis strain ID48908     
Function   repress competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IS/Tn 915242..916444 917403..918074 flank 959


Gene organization within MGE regions


Location: 915242..918074
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RMQ61_RS04620 (RMQ61_04625) - 915242..916444 (-) 1203 WP_313921432.1 IS110 family transposase -
  RMQ61_RS04625 (RMQ61_04630) - 916829..917209 (+) 381 WP_136670726.1 hypothetical protein -
  RMQ61_RS04630 (RMQ61_04635) ciaR 917403..918074 (+) 672 WP_024400692.1 response regulator transcription factor Regulator

Sequence

Protein


Download         Length: 223 a.a.        Molecular weight: 25275.98 Da        Isoelectric Point: 4.2132

>NTDB_id=884980 RMQ61_RS04630 WP_024400692.1 917403..918074(+) (ciaR) [Streptococcus suis strain ID48908]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPDKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide


Download         Length: 672 bp        

>NTDB_id=884980 RMQ61_RS04630 WP_024400692.1 917403..918074(+) (ciaR) [Streptococcus suis strain ID48908]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCAGATGT
TATGCAGGTTTTTGATGGTGAGGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGACAAAGATGGCTTTCAAGTCTTGAAAGAGTTACGTGAAAAGGGGGTTACGACACCAGTTCTGATTACCACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGAGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGACCTACTAGTTTAT
TTCTTGCAAAACCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGATAGTGATACTACAAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACTTTTGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGATACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3Q8BJ03

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

89.686

100

0.897
  ciaR Streptococcus pneumoniae Rx1

87.892

100

0.879
  ciaR Streptococcus pneumoniae D39

87.892

100

0.879
  ciaR Streptococcus pneumoniae R6

87.892

100

0.879
  ciaR Streptococcus pneumoniae TIGR4

87.892

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.053

100

0.386
  vicR Streptococcus mutans UA159

35.043

100

0.368