Detailed information NTG0879388

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: RI131_RS12035
• Genome accession: NZ_CP134216
• Coordinates: 2519243..2521435 (-)
• Length: 730 a.a.
• NCBI ID: WP_005686870.1
• Uniprot ID: A0A1Z1XG57
• Organism: Lacticaseibacillus rhamnosus strain VHProbi M12
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 2514243..2526435

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RI131_RS12010 (RI131_12010)	-	2514368..2515261 (-)	894	WP_107755086.1	IS3 family transposase	-
RI131_RS12015 (RI131_12015)	-	2515213..2515749 (-)	537	WP_014569708.1	helix-turn-helix domain-containing protein	-
RI131_RS12020 (RI131_12020)	-	2515845..2517200 (-)	1356	WP_005686876.1	threonine/serine exporter ThrE family protein	-
RI131_RS12025 (RI131_12025)	-	2517380..2517790 (-)	411	WP_005686874.1	hypothetical protein	-
RI131_RS12030 (RI131_12030)	-	2517851..2519230 (-)	1380	WP_031547267.1	bacteriocin secretion accessory protein	-
RI131_RS12035 (RI131_12035)	comA	2519243..2521435 (-)	2193	WP_005686870.1	peptide cleavage/export ABC transporter	Regulator
RI131_RS12040 (RI131_12040)	-	2521711..2521863 (-)	153	WP_005686869.1	bacteriocin-like peptide, LSEI_2386 family	-
RI131_RS12045 (RI131_12045)	-	2521963..2522979 (-)	1017	WP_014568877.1	IS30 family transposase	-
RI131_RS12050 (RI131_12050)	-	2523242..2524537 (+)	1296	WP_005686867.1	GHKL domain-containing protein	-
RI131_RS12055 (RI131_12055)	-	2524542..2525318 (+)	777	WP_005686865.1	response regulator transcription factor	-

Sequence

Protein

• Length: 730 a.a.
• Molecular weight: 81507.79 Da
• Isoelectric Point: 7.2454

>NTDB_id=879388 RI131_RS12035 WP_005686870.1 2519243..2521435(-) (comA) [Lacticaseibacillus rhamnosus strain VHProbi M12]
MVKYTPKLGQITYYKRFYTAQVDERDCGVAALNMLLKYNGSDYSLAHLRELAKTNQDGTTALGIVRAAEALAFETKPVQA
NMQLFDLEDVPYPFIAHVLKRGELLHYYVVFKATRTSILIGDPDPSVRMTWLSREVFEKEWSGVAIFIAPAPQYQPRKED
KGSLFAFVPMLAKQKGIIANIILAAVLITVISIVGSYFLQSIIDTYIPNAMRTTMGMIASGLLVAYLLQAVLTYGQNFLM
AVLGQRLAIDVILGYVRHLYELPMSFFSTRRTGEIVSRFADANKIIDALANTIMTLFLDVWIVLILGIVLGIQNGTLFLV
SLIAVPCYLVIVFAFQRPFDRLNQETMESNAILSSSIIEDLNGIETIKSLTGERVSYERVDREFLTYLKKSFSYTKADQL
QQAIKGLLKLALNVVVLWIGASLVIANRMSLGQMLTFNALLSYFTNPLESIINLQPKLQMARVANNRLNEVYLVESEFKE
QRHLTERHLIEGPIRVRDVSFKYGFGQDVLKNVNLEVPENAKYTIVGMSGSGKSTLAKLLVGFYPVDADKGTITFNGIPV
KDINLTTLRQYIEYVPQDPFIFSGTVLENLTLGSRSDVSEQDLTQACLAAEIAADIANLPQQWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGKIVEQGDHATLLAQ
DGYYARLVHE

Nucleotide

• Length: 2193 bp

>NTDB_id=879388 RI131_RS12035 WP_005686870.1 2519243..2521435(-) (comA) [Lacticaseibacillus rhamnosus strain VHProbi M12]
ATGGTTAAATACACCCCAAAACTAGGCCAGATCACCTACTACAAACGTTTCTACACCGCACAAGTTGACGAGCGTGACTG
TGGTGTGGCTGCGTTAAACATGCTGCTTAAATACAATGGGTCGGACTATTCGTTAGCCCACTTGCGCGAGTTAGCGAAGA
CAAATCAGGATGGCACGACGGCTTTGGGAATCGTTCGGGCCGCTGAAGCACTAGCGTTTGAGACGAAACCGGTGCAGGCG
AATATGCAGTTGTTTGATCTTGAGGATGTGCCTTATCCGTTTATTGCCCATGTGCTGAAGCGCGGTGAATTGCTTCATTA
CTATGTTGTTTTTAAAGCAACGCGCACGAGTATTCTGATTGGCGATCCTGACCCGTCAGTGCGCATGACCTGGCTTTCGC
GAGAGGTGTTTGAAAAAGAATGGTCGGGTGTGGCCATCTTTATTGCACCGGCGCCGCAGTATCAGCCGCGTAAGGAGGAC
AAAGGCAGTTTGTTTGCGTTTGTACCCATGCTGGCTAAGCAAAAAGGTATTATCGCGAACATTATTCTGGCCGCGGTATT
GATTACGGTCATTAGTATCGTTGGGTCGTATTTTTTGCAGTCTATTATTGATACGTATATACCGAATGCCATGCGGACGA
CGATGGGGATGATTGCTAGTGGCCTTTTGGTGGCTTACTTGCTGCAAGCTGTGTTGACTTATGGCCAGAATTTTTTGATG
GCGGTGTTGGGGCAGCGGCTTGCGATTGATGTCATTTTAGGGTATGTGCGCCACTTATATGAATTGCCGATGTCGTTTTT
TTCAACTCGGCGGACCGGAGAGATTGTGTCGCGGTTTGCGGATGCCAATAAAATTATTGACGCGCTGGCGAATACGATTA
TGACGTTGTTTTTGGATGTCTGGATTGTCCTAATATTAGGCATTGTTCTAGGGATCCAAAATGGGACTTTGTTTTTAGTG
TCATTGATTGCCGTGCCGTGTTATTTGGTGATTGTTTTTGCATTTCAGCGGCCGTTTGATCGGTTGAACCAAGAGACGAT
GGAAAGTAACGCAATCTTGAGTTCATCGATTATTGAAGATTTGAATGGCATTGAAACCATCAAGTCCCTGACCGGCGAAC
GAGTTAGCTATGAACGGGTTGATCGGGAATTTCTAACCTATCTGAAGAAATCGTTTAGTTACACCAAGGCAGATCAATTA
CAGCAAGCGATTAAAGGTCTGTTGAAGCTGGCGTTGAACGTTGTGGTGTTGTGGATTGGGGCAAGTTTGGTGATTGCCAA
TCGGATGAGCTTGGGGCAGATGCTGACCTTTAATGCACTGCTGTCATACTTTACGAATCCGCTTGAAAGCATCATCAACC
TACAGCCAAAGTTACAAATGGCGCGGGTTGCTAACAATCGCCTGAATGAAGTTTATCTGGTCGAATCGGAATTCAAAGAA
CAGCGGCACTTGACGGAGCGGCATTTAATCGAAGGTCCGATACGCGTTCGGGATGTCTCGTTTAAATATGGTTTTGGCCA
AGATGTATTGAAAAACGTCAACCTTGAAGTGCCGGAAAATGCTAAATATACCATTGTTGGCATGAGCGGTTCTGGTAAGT
CGACATTAGCAAAATTATTAGTTGGCTTTTACCCGGTTGATGCCGATAAAGGAACCATCACGTTTAATGGCATTCCGGTC
AAAGACATTAACCTGACAACATTACGGCAATATATTGAATATGTACCTCAGGATCCGTTTATTTTTTCGGGCACGGTGTT
GGAGAATTTGACGTTAGGTAGCCGTTCGGATGTTTCGGAACAAGATTTGACGCAGGCGTGTTTGGCTGCGGAAATTGCCG
CAGACATCGCAAACTTACCGCAGCAGTGGCAGACCAAATTGTCAGAAAGCGGCAGTATTTTATCAGGCGGTCAGAAGCAG
CGGCTGGCGATTGCACGGGCCTTGTTGTCACCGGCAAAAGTACTGATTTTTGACGAATCGACCAGCAGTCTGGATACCAT
TACAGAGCGAAAAATTGTCGATCGCTTGCTGGCAATGACGGATCGGACCATTATTTTTGTTGCCCATCGCTTAACTATTG
CGGCTAAAACCGAACAAATTGTGGTGATGGATCATGGCAAAATTGTGGAACAAGGTGACCATGCAACGTTGTTAGCCCAA
GACGGTTATTACGCGCGCCTGGTTCATGAGTGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (18-152)

• ABC transporter (ABC_tran) (510-662)

• ABC transporter transmembrane region (ABC_membrane) (180-448)

3D structure

• AlphaFold DB: A0A1Z1XG57

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus pneumoniae D39	58.182	97.945	0.57
comA	Streptococcus pneumoniae R6	58.182	97.945	0.57
comA	Streptococcus pneumoniae Rx1	58.182	97.945	0.57
comA	Streptococcus pneumoniae TIGR4	57.762	97.945	0.566
comA	Streptococcus mitis NCTC 12261	57.762	97.945	0.566
comA	Streptococcus mitis SK321	57.622	97.945	0.564
comA	Streptococcus gordonii str. Challis substr. CH1	56.606	98.493	0.558
comA/nlmT	Streptococcus mutans UA159	53.686	98.493	0.529