Detailed information NTG0874695

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: Q8F54_RS00420
• Genome accession: NZ_CP133477
• Coordinates: 71582..73729 (-)
• Length: 715 a.a.
• NCBI ID: WP_059442363.1
• Uniprot ID: A0A843Z1I8
• Organism: Leuconostoc mesenteroides strain F-22
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 66582..78729

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q8F54_RS00400 (Q8F54_00400)	-	67776..68363 (+)	588	WP_014324154.1	helix-turn-helix domain-containing protein	-
Q8F54_RS00405 (Q8F54_00405)	-	68421..69158 (+)	738	WP_061399584.1	SDR family NAD(P)-dependent oxidoreductase	-
Q8F54_RS00410 (Q8F54_00410)	-	69274..69399 (+)	126	WP_011679061.1	putative metal homeostasis protein	-
Q8F54_RS00415 (Q8F54_00415)	-	70215..71564 (-)	1350	WP_061399583.1	bacteriocin secretion accessory protein	-
Q8F54_RS00420 (Q8F54_00420)	comA	71582..73729 (-)	2148	WP_059442363.1	peptide cleavage/export ABC transporter	Regulator
Q8F54_RS00425 (Q8F54_00425)	-	73960..74136 (+)	177	WP_010287032.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
Q8F54_RS00430 (Q8F54_00430)	-	74167..74328 (+)	162	WP_010287029.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
Q8F54_RS00435 (Q8F54_00435)	-	74787..74924 (+)	138	WP_011679065.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
Q8F54_RS00440 (Q8F54_00440)	-	74939..75118 (+)	180	WP_010287277.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
Q8F54_RS00445 (Q8F54_00445)	-	75280..75456 (+)	177	WP_010287275.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
Q8F54_RS00450 (Q8F54_00450)	-	75719..75889 (+)	171	WP_011679066.1	hypothetical protein	-
Q8F54_RS00455 (Q8F54_00455)	-	75895..76107 (+)	213	WP_011679067.1	hypothetical protein	-
Q8F54_RS00460 (Q8F54_00460)	-	76379..77104 (-)	726	WP_011679068.1	response regulator transcription factor	-
Q8F54_RS00465 (Q8F54_00465)	-	77110..78090 (-)	981	WP_273954781.1	sensor histidine kinase	-

Sequence

Protein

• Length: 715 a.a.
• Molecular weight: 80410.39 Da
• Isoelectric Point: 9.2370

>NTDB_id=874695 Q8F54_RS00420 WP_059442363.1 71582..73729(-) (comA) [Leuconostoc mesenteroides strain F-22]
MRKFHYISQLEEKDCGVAALAMILKRHGSDVSLANIRERCQTSLSGTTALGLVKAAESFNMDVRPIQADLTLFNMKDLPL
PFIAHVEKKGQYLHYYVVYGFTKNKVIIADPDPTVAKTAMTLQEFSKEWTGVALFMSPSPRYKPFKENKNSILSFLPIIS
RQKGLIANIVVASLLVTLISIAGSYYMQLVIDTYIPSAMSNTLTVVSLGLIATYVLQQLLSFARTYLLTIMGQRLSIEVI
LSYIRHLFELPVNFFATRRTGEIVTRFNDANTIIDAMANTILSLFLDLGITIIVGSVLAIQNTKLFLLSLISFPIYFLIV
YCFMKPFERLNQEQMASNATLSSSIIEDINGIETIKSLTSEKTSYQKIDREFVDYLKKSFAHQKSEAIQNSIKQTTQLII
NVLVLWLGAKLVISNQISVGQLVTYNALLGYFTEPFQNIINLQAKLQTATVANRRLNEVYLVKSEFKKSESQELHHNNPH
NIIVDDVSYQYGYQKNILHHFSIKIPFGEKIALVGVSGSGKSTLAKLLVHFISPSAGNIFIGEQNIKHVQRQNLRQHILY
LPQNPYIFTGSILDNLTLGARENTTQEDILHAVELADIKDDIENMPQSYQTEISEEGGMSGGQKQRIALARALLSNSQIL
ILDESTSNLDVATEKKIIDNLLSLKNKTIIFIAHRLTIAEKVQRVILLEKGIISEDGSHAELIHKKSKYYHLVKH

Nucleotide

• Length: 2148 bp

>NTDB_id=874695 Q8F54_RS00420 WP_059442363.1 71582..73729(-) (comA) [Leuconostoc mesenteroides strain F-22]
ATGAGAAAGTTTCATTATATATCACAACTTGAAGAAAAAGATTGTGGCGTAGCAGCACTAGCTATGATTTTAAAGCGACA
CGGCTCAGATGTTTCATTAGCTAACATTCGTGAACGCTGTCAAACATCCCTATCGGGTACAACGGCGCTAGGCTTAGTGA
AGGCCGCTGAATCATTCAATATGGATGTCCGTCCTATTCAAGCTGACCTTACCTTATTCAACATGAAAGATTTGCCTCTG
CCGTTCATCGCTCATGTTGAGAAAAAAGGTCAATATTTGCATTATTATGTAGTGTACGGATTCACTAAAAACAAAGTTAT
CATTGCAGATCCAGATCCAACAGTTGCTAAAACCGCAATGACGTTACAAGAATTCTCTAAAGAGTGGACTGGTGTAGCAT
TGTTCATGTCGCCTTCACCCAGATATAAACCTTTTAAAGAAAATAAAAACAGTATCCTATCCTTTCTGCCAATTATTAGT
CGACAAAAAGGATTAATTGCTAATATTGTCGTCGCTTCTTTGCTAGTCACTTTAATTAGTATCGCTGGCTCTTATTATAT
GCAACTAGTGATTGATACTTATATTCCTAGTGCTATGTCTAACACATTAACCGTTGTTTCATTAGGACTCATTGCCACCT
ATGTGTTACAACAGCTACTTAGTTTTGCTCGCACCTATCTGTTAACTATTATGGGACAACGATTATCGATTGAAGTCATA
CTATCATACATACGGCACTTGTTCGAATTACCTGTTAATTTCTTTGCCACACGTCGAACAGGTGAAATTGTCACGCGTTT
TAATGACGCCAACACCATTATTGATGCCATGGCAAATACAATTCTCTCACTTTTTTTAGATTTAGGTATCACGATAATTG
TTGGCAGCGTCTTAGCAATTCAAAATACAAAACTTTTTCTGCTATCTCTAATCTCTTTTCCTATCTACTTCTTGATTGTC
TATTGTTTCATGAAGCCATTTGAACGATTGAATCAAGAACAGATGGCAAGTAATGCAACGCTGAGCTCATCTATTATTGA
AGACATCAATGGTATTGAAACCATAAAATCTTTGACAAGCGAGAAGACGAGCTACCAAAAAATTGATCGTGAATTTGTCG
ATTATTTAAAAAAATCCTTTGCCCATCAAAAAAGCGAAGCCATTCAAAATAGTATTAAACAAACAACTCAACTCATTATC
AATGTGCTCGTTTTATGGTTGGGTGCCAAGCTAGTGATTAGTAATCAAATTAGTGTCGGTCAGTTAGTTACCTATAATGC
ATTACTAGGCTACTTTACTGAACCTTTCCAAAATATTATTAACTTGCAGGCGAAATTACAAACGGCAACGGTTGCTAACC
GACGATTAAACGAAGTCTATCTTGTAAAATCAGAGTTTAAAAAATCAGAATCACAAGAGCTTCATCATAACAACCCTCAT
AACATTATAGTTGACGACGTCAGCTATCAATATGGTTATCAAAAGAACATATTACACCACTTTTCAATTAAGATCCCCTT
TGGTGAAAAAATTGCTCTGGTCGGTGTTAGCGGTTCCGGTAAGTCAACATTAGCCAAACTACTTGTTCATTTTATATCTC
CTAGTGCTGGCAACATTTTTATTGGTGAACAAAACATTAAACACGTTCAACGACAAAATTTAAGGCAACATATTCTTTAT
CTACCACAAAACCCATACATATTTACTGGAAGCATATTAGATAATTTAACACTAGGTGCTCGTGAAAACACAACACAAGA
AGACATCCTACATGCTGTTGAGCTTGCTGACATTAAAGATGACATCGAAAATATGCCACAAAGTTATCAAACCGAAATTT
CAGAGGAAGGCGGCATGTCTGGAGGCCAAAAGCAGCGTATCGCTTTAGCTAGAGCCCTCCTTAGTAATTCTCAAATACTT
ATTTTGGATGAATCAACCAGTAATCTTGATGTCGCAACTGAAAAAAAGATTATTGATAATTTATTATCGCTTAAAAATAA
AACAATCATTTTTATTGCACATCGCCTGACTATTGCTGAAAAAGTCCAACGCGTTATTCTGCTTGAAAAAGGGATCATCA
GTGAAGATGGTAGCCATGCTGAACTTATACATAAAAAATCAAAATACTATCATCTTGTAAAGCATTAA

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (498-647)

• Peptidase C39 family (Peptidase_C39) (3-140)

• ABC transporter transmembrane region (ABC_membrane) (168-436)

3D structure

• AlphaFold DB: A0A843Z1I8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus gordonii str. Challis substr. CH1	59.944	99.86	0.599
comA	Streptococcus mitis NCTC 12261	58.287	99.58	0.58
comA	Streptococcus mitis SK321	58.006	99.58	0.578
comA	Streptococcus pneumoniae Rx1	57.725	99.58	0.575
comA	Streptococcus pneumoniae D39	57.725	99.58	0.575
comA	Streptococcus pneumoniae R6	57.725	99.58	0.575
comA	Streptococcus pneumoniae TIGR4	57.444	99.58	0.572
comA/nlmT	Streptococcus mutans UA159	54.29	99.441	0.54