Detailed information NTG0874301

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: WJ054_RS02860
• Genome accession: NZ_CP149485
• Coordinates: 537539..539692 (-)
• Length: 717 a.a.
• NCBI ID: WP_084916306.1
• Uniprot ID: A0A223M041
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain STG643
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 532539..544692

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WJ054_RS02840 (WJ054_02835)	comE/blpR	533730..534479 (+)	750	WP_030126108.1	response regulator transcription factor	Regulator
WJ054_RS02845 (WJ054_02840)	-	534480..535814 (+)	1335	WP_063631787.1	sensor histidine kinase	-
WJ054_RS02850 (WJ054_02845)	-	535962..536087 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
WJ054_RS02855 (WJ054_02850)	-	536164..537528 (-)	1365	WP_084916305.1	bacteriocin secretion accessory protein	-
WJ054_RS02860 (WJ054_02855)	comA/nlmT	537539..539692 (-)	2154	WP_084916306.1	peptide cleavage/export ABC transporter	Regulator
WJ054_RS02865 (WJ054_02860)	-	539979..540206 (+)	228	WP_002992018.1	Blp family class II bacteriocin	-
WJ054_RS02870 (WJ054_02865)	-	540219..540419 (+)	201	WP_003060803.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
WJ054_RS02875 (WJ054_02870)	-	540713..540907 (+)	195	WP_002990768.1	hypothetical protein	-
WJ054_RS02880 (WJ054_02875)	-	540955..541236 (+)	282	WP_011054252.1	hypothetical protein	-
WJ054_RS02885 (WJ054_02880)	-	541430..541840 (+)	411	WP_003061293.1	hypothetical protein	-
WJ054_RS02890 (WJ054_02885)	-	542087..542334 (+)	248	Protein_512	hypothetical protein	-
WJ054_RS02895 (WJ054_02890)	-	542356..542610 (+)	255	WP_014612089.1	CPBP family intramembrane glutamic endopeptidase	-
WJ054_RS02900 (WJ054_02895)	-	542995..543759 (+)	765	WP_003061232.1	hypothetical protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80504.46 Da
• Isoelectric Point: 7.1728

>NTDB_id=874301 WJ054_RS02860 WP_084916306.1 537539..539692(-) (comA/nlmT) [Streptococcus dysgalactiae subsp. equisimilis strain STG643]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVIYQNKKNYLIIGDPDSTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLISFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVGYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIEIGSHQELMTKQGFYHHLFSS

Nucleotide

• Length: 2154 bp

>NTDB_id=874301 WJ054_RS02860 WP_084916306.1 537539..539692(-) (comA/nlmT) [Streptococcus dysgalactiae subsp. equisimilis strain STG643]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGATTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCATCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACTCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAGCTTTTTACCTCTC
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAT
GTTATTTTATCCTATATTCGTCATATTTTTGAGCTTCCCATGTCTTTCTTTGCAACACGTCGGACAGGAGAAATCATCTC
ACGTTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTCCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGGCTATCTGGATAAATCCTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACTAAACTGCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAGTTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCACTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAATAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTAGTTAA

Domains

Predicted by InterProScan.

• ABC transporter transmembrane region (ABC_membrane) (168-438)

• ABC transporter (ABC_tran) (500-649)

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: A0A223M041

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.448	99.721	0.722
comA	Streptococcus mitis NCTC 12261	67.227	99.582	0.669
comA	Streptococcus mitis SK321	66.807	99.582	0.665
comA	Streptococcus pneumoniae Rx1	66.807	99.582	0.665
comA	Streptococcus pneumoniae D39	66.807	99.582	0.665
comA	Streptococcus pneumoniae R6	66.807	99.582	0.665
comA	Streptococcus pneumoniae TIGR4	66.527	99.582	0.662
comA	Streptococcus gordonii str. Challis substr. CH1	65.738	100	0.658