NTDB

Overview

Name	htrA	Type	Regulator
Locus tag	Q7584_RS13840	Genome accession	NZ_CP131795
Coordinates	2830181..2831470 (-)	Length	429 a.a.
NCBI ID	WP_002290101.1	Uniprot ID	A0A828ZUK2
Organism	Enterococcus faecium strain 2016C10-291
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2825181..2836470

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7584_RS13810 (Q7584_13750)	-	2825625..2826578 (-)	954	WP_002299300.1	glycosyltransferase family 2 protein	-
Q7584_RS13815 (Q7584_13755)	-	2826763..2827113 (-)	351	WP_002309710.1	PepSY domain-containing protein	-
Q7584_RS13820 (Q7584_13760)	pepA	2827313..2828392 (+)	1080	WP_002294156.1	glutamyl aminopeptidase	-
Q7584_RS13825 (Q7584_13765)	-	2828535..2828855 (+)	321	WP_002292632.1	thioredoxin family protein	-
Q7584_RS13830 (Q7584_13770)	-	2828877..2829341 (+)	465	WP_002345012.1	universal stress protein	-
Q7584_RS13835 (Q7584_13775)	ytpR	2829537..2830142 (+)	606	WP_002313997.1	YtpR family tRNA-binding protein	-
Q7584_RS13840 (Q7584_13780)	htrA	2830181..2831470 (-)	1290	WP_002290101.1	trypsin-like peptidase domain-containing protein	Regulator
Q7584_RS13845 (Q7584_13785)	rlmH	2831898..2832377 (+)	480	WP_002345011.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
Q7584_RS13850 (Q7584_13790)	-	2832730..2833044 (+)	315	WP_000420682.1	YdcP family protein	-
Q7584_RS13855 (Q7584_13795)	-	2833060..2833446 (+)	387	WP_000985015.1	YdcP family protein	-
Q7584_RS13860 (Q7584_13800)	-	2833475..2834860 (+)	1386	WP_000813488.1	FtsK/SpoIIIE domain-containing protein	-
Q7584_RS13865 (Q7584_13805)	-	2834863..2835016 (+)	154	Protein_2683	conjugal transfer protein	-
Q7584_RS13870 (Q7584_13810)	mobT	2835039..2836244 (+)	1206	WP_000398284.1	MobT family relaxase	-

Sequence

Protein

Download Length: 429 a.a. Molecular weight: 44916.93 Da Isoelectric Point: 4.5419

                                >NTDB_id=865264 Q7584_RS13840 WP_002290101.1 2830181..2831470(-) (htrA) [Enterococcus faecium strain 2016C10-291]

MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA

VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVMMKD

GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE

TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG

ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT

YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide

Download Length: 1290 bp

                                >NTDB_id=865264 Q7584_RS13840 WP_002290101.1 2830181..2831470(-) (htrA) [Enterococcus faecium strain 2016C10-291]

ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT

TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA

CAAGCGGCAATCAAAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG

GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGATTATT

CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTAATCTACAAAA

AAGACGGGAATACTGCTTATGTAGTCACAAACAATCACGTAGTAGATGGACAGCAAGGTTTGGAAGTCATGATGAAAGAC

GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCCTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT

CGAAACGGTTGCCTCTTTTGGGGACTCAAGTGCTTTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGAT

CTGAATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACGAATGAATCGAACGAA

ACAGTCAATATCAATGCGATCCAAACAGATGCAGCGATCAACCCGGGAAATTCTGGTGGTCCTTTAGTGAATATCGAAGG

ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCGACTTCTAATGTAAGCGTAGAAGGAATGGGAT

TTGCCATCCCAAGTAACGATGTAGTGAATATCATCAACCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT

ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG

TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCAGAAAAAGCTGGGTTGAAACAATACGACGTCATTACTAAGATCG

ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT

TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG

TGAAAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(10-417)

Trypsin-like peptidase domain (Trypsin_2)

(127-272)

PDZ domain (PDZ_2)

(317-414)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A828ZUK2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
htrA	Streptococcus gordonii str. Challis substr. CH1	54.569	91.841	0.501
htrA	Streptococcus mutans UA159	60.169	82.517	0.496
htrA	Streptococcus mitis NCTC 12261	52.778	92.308	0.487
htrA	Streptococcus pneumoniae TIGR4	59.05	78.555	0.464
htrA	Streptococcus pneumoniae Rx1	59.05	78.555	0.464
htrA	Streptococcus pneumoniae D39	59.05	78.555	0.464
htrA	Streptococcus pneumoniae R6	59.05	78.555	0.464

Detailed information NTG0865264