Detailed information NTG0864268

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: Q7621_RS05435
• Genome accession: NZ_CP131712
• Coordinates: 1113954..1114658 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain 2008C09-280
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1108954..1119658

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7621_RS05405 (Q7621_05400)	-	1108969..1109742 (-)	774	WP_000731139.1	ion channel	-
Q7621_RS05410 (Q7621_05405)	-	1109789..1110043 (-)	255	WP_001809704.1	type II toxin-antitoxin system RelE/ParE family toxin	-
Q7621_RS05415 (Q7621_05410)	-	1110045..1110287 (-)	243	WP_000208080.1	DUF6290 family protein	-
Q7621_RS05420 (Q7621_05415)	-	1110482..1111738 (+)	1257	WP_000436237.1	ISL3-like element IS1167A family transposase	-
Q7621_RS05425 (Q7621_05420)	vicX	1111801..1112610 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
Q7621_RS05430 (Q7621_05425)	micB	1112612..1113961 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
Q7621_RS05435 (Q7621_05430)	micA	1113954..1114658 (-)	705	WP_000722076.1	response regulator YycF	Regulator
Q7621_RS05440 (Q7621_05435)	mutY	1114713..1115888 (-)	1176	Protein_1074	A/G-specific adenine glycosylase	-
Q7621_RS05445 (Q7621_05440)	-	1115985..1116110 (+)	126	WP_001818232.1	hypothetical protein	-
Q7621_RS05450 (Q7621_05445)	-	1116216..1117886 (-)	1671	WP_000845292.1	formate--tetrahydrofolate ligase	-
Q7621_RS05455 (Q7621_05450)	coaB	1118116..1118805 (+)	690	WP_000699492.1	phosphopantothenate--cysteine ligase	-
Q7621_RS05460 (Q7621_05455)	coaC	1118817..1119368 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=864268 Q7621_RS05435 WP_000722076.1 1113954..1114658(-) (micA) [Streptococcus pneumoniae strain 2008C09-280]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=864268 Q7621_RS05435 WP_000722076.1 1113954..1114658(-) (micA) [Streptococcus pneumoniae strain 2008C09-280]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTATGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACACGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38