Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC2   Type   Regulator
Locus tag   Q7625_RS11070 Genome accession   NZ_CP131708
Coordinates   2172515..2172640 (-) Length   41 a.a.
NCBI ID   WP_000799694.1    Uniprot ID   Q9WW44
Organism   Streptococcus pneumoniae strain 2016C10-332     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 2167515..2177640
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Q7625_RS11040 (Q7625_11015) - 2167854..2169456 (-) 1603 Protein_2137 YhgE/Pip domain-containing protein -
  Q7625_RS11045 (Q7625_11020) - 2169635..2170177 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  Q7625_RS11060 (Q7625_11035) comE 2170420..2171172 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  Q7625_RS11065 (Q7625_11040) comD/comD2 2171169..2172494 (-) 1326 WP_000364843.1 competence system sensor histidine kinase ComD Regulator
  Q7625_RS11070 (Q7625_11045) comC/comC2 2172515..2172640 (-) 126 WP_000799694.1 competence-stimulating peptide ComC Regulator
  Q7625_RS11080 (Q7625_11055) rlmH 2172922..2173401 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  Q7625_RS11085 (Q7625_11060) htrA 2173584..2174765 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  Q7625_RS11090 (Q7625_11065) spo0J 2174823..2175581 (+) 759 WP_000410378.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4892.93 Da        Isoelectric Point: 10.9061

>NTDB_id=864008 Q7625_RS11070 WP_000799694.1 2172515..2172640(-) (comC/comC2) [Streptococcus pneumoniae strain 2016C10-332]
MKNTVKLEQFVALKEKDLQNIKGGEMRISRIILDFLFLRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=864008 Q7625_RS11070 WP_000799694.1 2172515..2172640(-) (comC/comC2) [Streptococcus pneumoniae strain 2016C10-332]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAATATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-29)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9WW44

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

97.561

100

0.976
  comC/comC2 Streptococcus pneumoniae TIGR4

97.561

100

0.976
  comC/comC1 Streptococcus pneumoniae R6

78.049

100

0.78
  comC/comC1 Streptococcus pneumoniae G54

78.049

100

0.78
  comC/comC1 Streptococcus pneumoniae D39

78.049

100

0.78
  comC/comC1 Streptococcus pneumoniae Rx1

78.049

100

0.78
  comC Streptococcus mitis SK321

75.61

100

0.756
  comC Streptococcus mitis NCTC 12261

60

97.561

0.585