Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   Q7625_RS03550 Genome accession   NZ_CP131708
Coordinates   697513..698187 (+) Length   224 a.a.
NCBI ID   WP_000590619.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 2016C10-332     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IS/Tn 696039..697295 697513..698187 flank 218


Gene organization within MGE regions


Location: 696039..698187
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Q7625_RS03545 (Q7625_03535) - 696039..697295 (-) 1257 WP_000436228.1 ISL3-like element IS1167A family transposase -
  Q7625_RS03550 (Q7625_03540) ciaR 697513..698187 (+) 675 WP_000590619.1 two-component system response regulator CiaR Regulator

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25480.32 Da        Isoelectric Point: 4.3283

>NTDB_id=863952 Q7625_RS03550 WP_000590619.1 697513..698187(+) (ciaR) [Streptococcus pneumoniae strain 2016C10-332]
MIKILLIEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=863952 Q7625_RS03550 WP_000590619.1 697513..698187(+) (ciaR) [Streptococcus pneumoniae strain 2016C10-332]
ATGATAAAAATCTTATTGATTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
TATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGTGTCTATGACTTGATTTTGCTGGATTTGATGT
TGCCAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGAATTCAGGCCCTTCTCAAACGTTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGG
TTAATTTATCAACCAATACCGTTAAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

99.554

100

0.996
  ciaR Streptococcus pneumoniae D39

99.554

100

0.996
  ciaR Streptococcus pneumoniae R6

99.554

100

0.996
  ciaR Streptococcus pneumoniae TIGR4

99.554

100

0.996
  ciaR Streptococcus mutans UA159

87.946

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.168

100

0.375
  vicR Streptococcus mutans UA159

35.193

100

0.366