Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   LLUC029_RS12010 Genome accession   NZ_CP129163
Coordinates   2291767..2292990 (+) Length   407 a.a.
NCBI ID   WP_021164968.1    Uniprot ID   A0A166Z084
Organism   Lactococcus cremoris strain UC029     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2286767..2297990
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LLUC029_RS11985 (LLUC029_12005) - 2287882..2288685 (-) 804 WP_011677190.1 phosphatidate cytidylyltransferase -
  LLUC029_RS11990 (LLUC029_12010) - 2288685..2289419 (-) 735 WP_032951303.1 isoprenyl transferase -
  LLUC029_RS11995 (LLUC029_12015) yajC 2289769..2290101 (-) 333 WP_011677192.1 preprotein translocase subunit YajC -
  LLUC029_RS12000 (LLUC029_12020) - 2290196..2290894 (-) 699 Protein_2338 DNA alkylation repair protein -
  LLUC029_RS12005 (LLUC029_12025) rlmH 2290912..2291391 (-) 480 WP_021164969.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  LLUC029_RS12010 (LLUC029_12030) htrA 2291767..2292990 (+) 1224 WP_021164968.1 S1C family serine protease Regulator
  LLUC029_RS12015 (LLUC029_12035) - 2293112..2294110 (+) 999 WP_032951305.1 glycosyltransferase family 4 protein -
  LLUC029_RS12020 (LLUC029_12040) - 2294248..2295588 (+) 1341 WP_014573350.1 glycosyltransferase family 4 protein -
  LLUC029_RS12025 (LLUC029_12045) - 2295696..2295920 (+) 225 WP_011677198.1 YkuJ family protein -
  LLUC029_RS12030 (LLUC029_12050) - 2296064..2297068 (+) 1005 WP_021164965.1 hypothetical protein -
  LLUC029_RS12035 (LLUC029_12055) - 2297125..2297877 (-) 753 WP_021164964.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -

Sequence

Protein


Download         Length: 407 a.a.        Molecular weight: 41585.05 Da        Isoelectric Point: 5.3802

>NTDB_id=851369 LLUC029_RS12010 WP_021164968.1 2291767..2292990(+) (htrA) [Lactococcus cremoris strain UC029]
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQLGNANRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKQNS
QSDFSSIFGGNSGSSSANDSLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKATVVGYDEYTDLAVL
KISSDHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTSINAIQTDAAINPGNSGG
ALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLETDGKISRPALGIRMVDLSQLSTNDSSQLKLPSS
VTGGLVVYSVQAGLPAATAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSATANVKLSKSTSDLET
NSSSSSN

Nucleotide


Download         Length: 1224 bp        

>NTDB_id=851369 LLUC029_RS12010 WP_021164968.1 2291767..2292990(+) (htrA) [Lactococcus cremoris strain UC029]
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACCGGTGTTGTGGGTGGAGCTATCGCACTCGGAGGAAGCGCAATTTA
TCAAAGCACTACAAACCAACTAGGAAATGCTAACCGCTCAAATACAACTAGCACAAAGGTTAGTAATGTTTCGGTAAATG
TCAATACCGATGTCACCTCTGCAATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAACAGAATTCA
CAAAGTGATTTTAGTTCAATTTTTGGTGGAAATAGCGGCTCAAGTTCAGCTAATGACAGCTTGCAACTTTCCAGTGAGGG
TTCTGGTGTTATTTATAAAAAATCTGGTGGAGATGCTTACGTGGTCACTAACTATCACGTTATTGCTGGAAATAGTTCCC
TCGATGTTTTACTTTCTGGTGGGCAAAAAGTTAAAGCCACAGTTGTTGGTTATGATGAATACACTGACCTTGCCGTTCTT
AAAATCAGCTCTGACCATGTTAAAGACGTGGCAACTTTCGCTGATTCAAGCAAGTTAACTATTGGTGAACCAGCTATTGC
AGTCGGCTCACCTTTAGGTAGCCAGTTTGCTAATACTGCAACCGAAGGAATTCTGTCTGCAACAAGTCGTCAAGTCACTT
TGACTCAAGAAAATGGTCAAACAACAAGTATCAATGCGATTCAAACGGATGCTGCCATTAACCCGGGTAACTCAGGTGGA
GCCTTGATTAATATTGAAGGTCAAGTGATTGGTATTACTCAAAGTAAAATCACAACGACCGAAGATGGTTCTACCTCTGT
GGAAGGTTTAGGTTTTGCTATCCCATCTAATGATGTGGTAAACATCATTAATAAACTTGAAACTGATGGTAAGATTTCAC
GTCCTGCCTTAGGTATTCGTATGGTTGACCTATCTCAATTATCAACAAATGATAGTTCTCAACTGAAATTACCTAGCAGC
GTAACTGGTGGATTGGTTGTCTACTCTGTTCAAGCGGGTCTTCCTGCTGCCACAGCTGGTCTGAAAGCTGGCGATGTGAT
AACGAAGGTGGGAGATACCGCCGTTACTTCATCAACAGACTTACAAAGTGCTCTTTACTCACACAATATTAATGATACTG
TGAAAGTCACCTACTACCGTGATGGTAAATCAGCCACAGCAAATGTTAAACTCTCTAAATCAACAAGCGATTTAGAAACA
AATAGTTCATCTTCTTCTAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(237-395)

PDZ domain (PDZ_2)

(295-391)

Trypsin-like peptidase domain (Trypsin_2)

(107-252)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A166Z084

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

55.875

94.103

0.526
  htrA Streptococcus gordonii str. Challis substr. CH1

54.872

95.823

0.526
  htrA Streptococcus pneumoniae Rx1

58.14

84.521

0.491
  htrA Streptococcus pneumoniae D39

58.14

84.521

0.491
  htrA Streptococcus pneumoniae R6

58.14

84.521

0.491
  htrA Streptococcus pneumoniae TIGR4

58.14

84.521

0.491
  htrA Streptococcus mutans UA159

53.117

90.663

0.482