Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   QWG62_RS06250 Genome accession   NZ_CP128995
Coordinates   1084386..1085675 (+) Length   429 a.a.
NCBI ID   WP_047927734.1    Uniprot ID   -
Organism   Enterococcus faecium strain AK_C_05     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1079386..1090675
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QWG62_RS06230 (QWG62_06230) licT 1080041..1080898 (-) 858 WP_002337037.1 BglG family transcription antiterminator LicT -
  QWG62_RS06235 (QWG62_06235) - 1081206..1082396 (+) 1191 WP_002344697.1 IS256 family transposase -
  QWG62_RS06240 (QWG62_06240) - 1082494..1083168 (-) 675 WP_277885175.1 hypothetical protein -
  QWG62_RS06245 (QWG62_06245) rlmH 1083479..1083958 (-) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  QWG62_RS06250 (QWG62_06250) htrA 1084386..1085675 (+) 1290 WP_047927734.1 trypsin-like peptidase domain-containing protein Regulator
  QWG62_RS06255 (QWG62_06255) ytpR 1085714..1086319 (-) 606 WP_002313997.1 YtpR family tRNA-binding protein -
  QWG62_RS06260 (QWG62_06260) - 1086515..1086979 (-) 465 WP_002292633.1 universal stress protein -
  QWG62_RS06265 (QWG62_06265) - 1087001..1087321 (-) 321 WP_002292632.1 thioredoxin family protein -
  QWG62_RS06270 (QWG62_06270) pepA 1087464..1088543 (-) 1080 WP_047927732.1 glutamyl aminopeptidase -
  QWG62_RS06275 (QWG62_06275) - 1088743..1089093 (+) 351 WP_002309710.1 PepSY domain-containing protein -
  QWG62_RS06280 (QWG62_06280) - 1089316..1090263 (+) 948 WP_002289860.1 glycosyltransferase family 2 protein -

Sequence

Protein


Download         Length: 429 a.a.        Molecular weight: 44959.01 Da        Isoelectric Point: 4.5419

>NTDB_id=850320 QWG62_RS06250 WP_047927734.1 1084386..1085675(+) (htrA) [Enterococcus faecium strain AK_C_05]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAVIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVMMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1290 bp        

>NTDB_id=850320 QWG62_RS06250 WP_047927734.1 1084386..1085675(+) (htrA) [Enterococcus faecium strain AK_C_05]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTGGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGTCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAAAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGATTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTAATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACAAACAATCACGTAGTAGATGGACAGCAAGGTTTGGAAGTCATGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCCTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACGGTTGCCTCTTTTGGGGACTCAAGTGCTTTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCCCCATTAGGAT
CTGAATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCGATCAATCCGGGAAATTCTGGTGGTCCTTTAGTGAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCGACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCCATCCCAAGTAACGATGTAGTGAATATCATCAACCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCAGAAAAAGCTGGGTTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(10-417)

Trypsin-like peptidase domain (Trypsin_2)

(127-272)

PDZ domain (PDZ_2)

(317-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.315

91.841

0.499
  htrA Streptococcus mutans UA159

60.169

82.517

0.496
  htrA Streptococcus mitis NCTC 12261

52.778

92.308

0.487
  htrA Streptococcus pneumoniae TIGR4

59.05

78.555

0.464
  htrA Streptococcus pneumoniae D39

59.05

78.555

0.464
  htrA Streptococcus pneumoniae Rx1

59.05

78.555

0.464
  htrA Streptococcus pneumoniae R6

59.05

78.555

0.464