Detailed information NTG0843665

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QRA12_RS13240
• Genome accession: NZ_CP127345
• Coordinates: 2685422..2686465 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain MRSA11
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2680422..2691465

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QRA12_RS13210 (QRA12_13195)	-	2680844..2682100 (-)	1257	WP_001789555.1	aminopeptidase	-
QRA12_RS13215 (QRA12_13200)	-	2682103..2682303 (-)	201	WP_000180460.1	DUF1128 family protein	-
QRA12_RS13220 (QRA12_13205)	-	2682450..2682914 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
QRA12_RS13225 (QRA12_13210)	-	2682921..2683196 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
QRA12_RS13230 (QRA12_13215)	-	2683474..2684691 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
QRA12_RS13235 (QRA12_13220)	vraR	2684803..2685432 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QRA12_RS13240 (QRA12_13225)	vraS	2685422..2686465 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QRA12_RS13245 (QRA12_13230)	liaF	2686462..2687163 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QRA12_RS13250 (QRA12_13235)	-	2687178..2687564 (-)	387	WP_001110179.1	hypothetical protein	-
QRA12_RS13255 (QRA12_13240)	map	2687781..2688539 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
QRA12_RS13260 (QRA12_13245)	-	2689129..2690115 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
QRA12_RS13265 (QRA12_13250)	-	2690546..2690959 (-)	414	WP_001566709.1	hypothetical protein	-
QRA12_RS13270 (QRA12_13255)	-	2690988..2691099 (-)	112	Protein_2571	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=843665 QRA12_RS13240 WP_001017131.1 2685422..2686465(-) (vraS) [Staphylococcus aureus strain MRSA11]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=843665 QRA12_RS13240 WP_001017131.1 2685422..2686465(-) (vraS) [Staphylococcus aureus strain MRSA11]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1