Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   LL303_RS12345 Genome accession   NZ_CP126467
Coordinates   2401522..2402748 (+) Length   408 a.a.
NCBI ID   WP_023164659.1    Uniprot ID   A0AAP4NDU0
Organism   Lactococcus lactis subsp. lactis strain 303     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2396522..2407748
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LL303_RS12320 (LL303_12290) - 2397615..2398418 (-) 804 WP_003130590.1 phosphatidate cytidylyltransferase -
  LL303_RS12325 (LL303_12295) - 2398418..2399152 (-) 735 WP_023164656.1 isoprenyl transferase -
  LL303_RS12330 (LL303_12300) yajC 2399524..2399856 (-) 333 WP_003130588.1 preprotein translocase subunit YajC -
  LL303_RS12335 (LL303_12305) - 2399951..2400649 (-) 699 WP_023164657.1 DNA alkylation repair protein -
  LL303_RS12340 (LL303_12310) rlmH 2400668..2401147 (-) 480 WP_023164658.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  LL303_RS12345 (LL303_12315) htrA 2401522..2402748 (+) 1227 WP_023164659.1 S1C family serine protease Regulator
  LL303_RS12350 (LL303_12320) - 2402874..2403872 (+) 999 WP_010906330.1 glycosyltransferase family 4 protein -
  LL303_RS12355 (LL303_12325) - 2403998..2405338 (+) 1341 WP_010906331.1 glycosyltransferase family 4 protein -
  LL303_RS12360 (LL303_12330) - 2405446..2405670 (+) 225 WP_003130579.1 YkuJ family protein -
  LL303_RS12365 (LL303_12335) - 2405812..2406816 (+) 1005 WP_012898633.1 hypothetical protein -
  LL303_RS12370 (LL303_12340) - 2406857..2407609 (-) 753 WP_010906333.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -

Sequence

Protein


Download         Length: 408 a.a.        Molecular weight: 41663.97 Da        Isoelectric Point: 5.1429

>NTDB_id=838054 LL303_RS12345 WP_023164659.1 2401522..2402748(+) (htrA) [Lactococcus lactis subsp. lactis strain 303]
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQSANNSRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKDNS
QSSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKASVVGYDEYTDLAV
LKISSEHVKDVATFADSNKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSG
GALINIEGQVIGITQSKITTTENGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGIRMVDLSQLSTNDSSQLKLPS
SVTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLE
TSSSSSSN

Nucleotide


Download         Length: 1227 bp        

>NTDB_id=838054 LL303_RS12345 WP_023164659.1 2401522..2402748(+) (htrA) [Lactococcus lactis subsp. lactis strain 303]
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACAGGTGTCGTGGGCGGAGCCATCGCACTTGGAGGAAGTGCAATCTA
TCAAAGCACTACAAATCAATCGGCAAATAATAGTCGTTCAAATACAACTAGTACAAAGGTTAGTAACGTTTCGGTAAATG
TCAATACCGATGTTACCTCTGCAATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAAGATAACTCA
CAAAGTAGTGACTTCAGTTCAATTTTTGGTGGAAATAGCGGTTCAAGTTCATCGACTGATGGCTTACAGCTTTCTAGTGA
AGGCTCTGGTGTCATCTACAAAAAATCTGGTGGTGATGCCTACGTTGTAACTAACTACCACGTTATTGCTGGTAATAGCT
CACTTGATGTTCTGCTTTCTGGTGGACAAAAAGTCAAAGCTTCTGTGGTTGGTTATGATGAATACACAGACCTTGCTGTT
CTTAAAATCAGTTCTGAACATGTCAAAGATGTGGCGACATTCGCTGATTCTAATAAATTAACAATTGGTGAACCTGCCAT
TGCCGTTGGCTCACCTTTAGGTAGTCAATTTGCAAACACCGCAACTGAAGGAATTTTATCTGCAACAAGCCGTCAAGTGA
CTTTGACCCAAGAAAATGGTCAAACAACTAATATCAATGCAATTCAAACAGATGCTGCCATTAACCCTGGTAACTCTGGA
GGGGCTTTGATTAATATTGAAGGACAAGTTATTGGAATTACTCAAAGTAAAATTACAACAACTGAAAATGGTTCTACTTC
TGTCGAAGGTTTAGGATTTGCGATTCCTTCTAATGATGTCGTAAATATCATTAATAAACTTGAAGCTGATGGTAAGATTT
CACGCCCTGCTTTAGGTATCCGAATGGTTGACCTTTCACAATTATCAACAAATGACAGTTCTCAATTGAAATTACCAAGC
AGTGTAACAGGTGGGGTTGTTGTTTACTCCGTCCAATCTGGACTTCCTGCTGCCTCAGCTGGTTTGAAAGCTGGAGATGT
AATTACAAAGGTTGGCGATACAGCAGTAACTTCTTCAACAGACTTGCAAAGTGCTCTTTACTCACACAATATCAATGATA
CAGTAAAAGTTACTTATTATCGTGATGGTAAATCAAATACAGCAGATGTTAAACTTTCTAAATCAACCAGTGACTTAGAA
ACAAGCAGTTCATCTTCTTCTAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(296-392)

Peptidase family M50 (Peptidase_M50)

(225-396)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

56.283

93.627

0.527
  htrA Streptococcus gordonii str. Challis substr. CH1

54.476

95.833

0.522
  htrA Streptococcus pneumoniae D39

58.309

84.069

0.49
  htrA Streptococcus pneumoniae TIGR4

58.309

84.069

0.49
  htrA Streptococcus pneumoniae R6

58.309

84.069

0.49
  htrA Streptococcus pneumoniae Rx1

58.309

84.069

0.49
  htrA Streptococcus mutans UA159

53.261

90.196

0.48