Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   H7680_RS05470 Genome accession   NZ_AP023394
Coordinates   1090836..1091510 (-) Length   224 a.a.
NCBI ID   WP_014612304.1    Uniprot ID   -
Organism   Streptococcus dysgalactiae subsp. equisimilis strain 159     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1085836..1096510
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7680_RS05445 (SDSE159_10570) - 1086021..1087298 (-) 1278 WP_014612301.1 pyrimidine-nucleoside phosphorylase -
  H7680_RS05450 (SDSE159_10580) - 1087285..1087884 (-) 600 WP_138128085.1 class I SAM-dependent methyltransferase -
  H7680_RS05455 (SDSE159_10590) coaA 1088153..1089073 (+) 921 WP_003058858.1 type I pantothenate kinase -
  H7680_RS05460 (SDSE159_10600) rpsT 1089127..1089375 (+) 249 WP_009881183.1 30S ribosomal protein S20 -
  H7680_RS05465 (SDSE159_10610) ciaH 1089533..1090843 (-) 1311 WP_014612303.1 HAMP domain-containing sensor histidine kinase Regulator
  H7680_RS05470 (SDSE159_10620) ciaR 1090836..1091510 (-) 675 WP_014612304.1 response regulator transcription factor Regulator
  H7680_RS05475 (SDSE159_10630) - 1091714..1094251 (-) 2538 WP_014612305.1 M1 family metallopeptidase -
  H7680_RS05480 (SDSE159_10640) phoU 1094452..1095105 (-) 654 WP_003057760.1 phosphate signaling complex protein PhoU -
  H7680_RS05485 (SDSE159_10650) pstB 1095183..1095941 (-) 759 WP_003057749.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25592.57 Da        Isoelectric Point: 4.4128

>NTDB_id=83067 H7680_RS05470 WP_014612304.1 1090836..1091510(-) (ciaR) [Streptococcus dysgalactiae subsp. equisimilis strain 159]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KESLDDKGQGFELGADDYLTKPFYLEELKMRIQALLKRTGKFTDKNLAFGNVVVDLGQKEVQVDGRPIELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTDFVDKLQTLRSVGYILKSHE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=83067 H7680_RS05470 WP_014612304.1 1090836..1091510(-) (ciaR) [Streptococcus dysgalactiae subsp. equisimilis strain 159]
ATGATCAAACTATTATTAGTAGAAGATGACTTAAGTTTATCCAATTCCATTTTCGATTTTTTGGATGATTTTGCTGATGT
CACACAAGTTTTTGATGGCGATGAAGGCTTATATGAAGCCGAAAGTGGCATTTACGATTTGATTTTACTTGACCTTATGT
TGCCAGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGTTGATTATGACAGCC
AAAGAAAGTCTAGATGATAAGGGACAGGGCTTTGAATTAGGAGCAGATGATTACCTCACTAAGCCTTTTTACCTGGAGGA
ACTCAAGATGCGAATTCAAGCCCTGTTAAAACGTACAGGGAAATTCACGGATAAAAATCTAGCCTTTGGGAATGTCGTAG
TGGATTTAGGACAAAAAGAAGTTCAAGTGGATGGCCGGCCGATAGAACTATTAGGTAAAGAGTTTGATTTGTTGGTCTAC
CTGTTACAAAATCAGAATGTTATTTTACCTAAAACACAAATTTTTGATCGCTTATGGGGTTTTGATAGCGATACGACCAT
TTCAGTAGTTGAAGTTTACGTTTCTAAAATTAGAAAAAAACTGAAAGGTACAGATTTTGTGGACAAACTGCAGACATTGA
GAAGCGTGGGGTATATTCTAAAAAGCCATGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(5-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

84.163

98.661

0.83
  ciaR Streptococcus pneumoniae D39

84.163

98.661

0.83
  ciaR Streptococcus pneumoniae R6

84.163

98.661

0.83
  ciaR Streptococcus pneumoniae TIGR4

84.163

98.661

0.83
  ciaR Streptococcus mutans UA159

83.71

98.661

0.826
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.326

100

0.388
  vicR Streptococcus mutans UA159

35.443

100

0.375

Multiple sequence alignment