Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   R4712_RS09895 Genome accession   NZ_CP137110
Coordinates   1904449..1905186 (+) Length   245 a.a.
NCBI ID   WP_000782676.1    Uniprot ID   C1CQZ3
Organism   Streptococcus pneumoniae strain 16H2041     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1899449..1910186
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4712_RS09875 - 1899646..1900749 (+) 1104 WP_000225893.1 glycosyltransferase -
  R4712_RS09880 - 1900751..1901737 (+) 987 WP_044812382.1 glycosyltransferase family 2 protein -
  R4712_RS09885 - 1901753..1903186 (+) 1434 WP_000565099.1 O-antigen polysaccharide polymerase Wzy family protein -
  R4712_RS09890 - 1903215..1904249 (+) 1035 WP_000461498.1 hypothetical protein -
  R4712_RS09895 mecA 1904449..1905186 (+) 738 WP_000782676.1 adaptor protein MecA Regulator
  R4712_RS09900 - 1905337..1906623 (+) 1287 WP_044812381.1 homoserine dehydrogenase -
  R4712_RS09905 thrB 1906625..1907494 (+) 870 WP_000692438.1 homoserine kinase -
  R4712_RS09910 - 1907570..1907722 (+) 153 WP_001812125.1 hypothetical protein -
  R4712_RS09915 msrB 1907789..1908727 (+) 939 WP_317818544.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28381.18 Da        Isoelectric Point: 4.0199

>NTDB_id=819685 R4712_RS09895 WP_000782676.1 1904449..1905186(+) (mecA) [Streptococcus pneumoniae strain 16H2041]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=819685 R4712_RS09895 WP_000782676.1 1904449..1905186(+) (mecA) [Streptococcus pneumoniae strain 16H2041]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterProScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1CQZ3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus pneumoniae TIGR4

99.184

100

0.992
  mecA Streptococcus thermophilus LMD-9

47.791

100

0.486
  mecA Streptococcus thermophilus LMG 18311

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482