Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   R8613_RS06515 Genome accession   NZ_AP026919
Coordinates   1255024..1255761 (-) Length   245 a.a.
NCBI ID   WP_000782676.1    Uniprot ID   C1CQZ3
Organism   Streptococcus pneumoniae strain PZ900700012     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1250024..1260761
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8613_RS06495 (PC0012_12580) msrB 1251483..1252421 (-) 939 WP_000818203.1 peptide-methionine (R)-S-oxide reductase MsrB -
  R8613_RS06500 (PC0012_12590) - 1252488..1252640 (-) 153 WP_001835993.1 hypothetical protein -
  R8613_RS06505 (PC0012_12600) thrB 1252716..1253585 (-) 870 WP_000692438.1 homoserine kinase -
  R8613_RS06510 (PC0012_12610) - 1253587..1254873 (-) 1287 WP_000216382.1 homoserine dehydrogenase -
  R8613_RS06515 (PC0012_12620) mecA 1255024..1255761 (-) 738 WP_000782676.1 adaptor protein MecA Regulator
  R8613_RS06520 (PC0012_12630) - 1256046..1257302 (+) 1257 WP_317648101.1 ISL3 family transposase -
  R8613_RS06525 (PC0012_12640) - 1257383..1258417 (-) 1035 WP_000461498.1 hypothetical protein -
  R8613_RS06530 (PC0012_12650) - 1258446..1259879 (-) 1434 WP_000565088.1 O-antigen polysaccharide polymerase Wzy family protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28381.18 Da        Isoelectric Point: 4.0199

>NTDB_id=81965 R8613_RS06515 WP_000782676.1 1255024..1255761(-) (mecA) [Streptococcus pneumoniae strain PZ900700012]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=81965 R8613_RS06515 WP_000782676.1 1255024..1255761(-) (mecA) [Streptococcus pneumoniae strain PZ900700012]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGTATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTAGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterProScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1CQZ3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus pneumoniae TIGR4

99.184

100

0.992
  mecA Streptococcus thermophilus LMD-9

47.791

100

0.486
  mecA Streptococcus thermophilus LMG 18311

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482

Multiple sequence alignment