Detailed information NTG0819172

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QAY78_RS00455
• Genome accession: NZ_CP123128
• Coordinates: 81145..82188 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain GE-MSSA31
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76145..87188

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAY78_RS00425 (QAY78_00420)	-	76713..76822 (+)	110	Protein_84	hypothetical protein	-
QAY78_RS00430 (QAY78_00425)	-	76851..77264 (+)	414	WP_001622129.1	hypothetical protein	-
QAY78_RS00435 (QAY78_00430)	-	77442..78428 (-)	987	WP_000999713.1	FUSC family protein	-
QAY78_RS00440 (QAY78_00435)	map	79071..79829 (+)	759	WP_000636137.1	type I methionyl aminopeptidase	-
QAY78_RS00445 (QAY78_00440)	-	80046..80432 (+)	387	WP_001110184.1	hypothetical protein	-
QAY78_RS00450 (QAY78_00445)	liaF	80447..81148 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QAY78_RS00455 (QAY78_00450)	vraS	81145..82188 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QAY78_RS00460 (QAY78_00455)	vraR	82178..82807 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QAY78_RS00465 (QAY78_00460)	-	82920..84137 (-)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
QAY78_RS00470 (QAY78_00465)	-	84415..84690 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
QAY78_RS00475 (QAY78_00470)	-	84697..85161 (-)	465	WP_000228668.1	low molecular weight protein-tyrosine-phosphatase	-
QAY78_RS00480 (QAY78_00475)	-	85308..85508 (+)	201	WP_000180459.1	DUF1128 family protein	-
QAY78_RS00485 (QAY78_00480)	-	85577..86767 (+)	1191	WP_411896787.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=819172 QAY78_RS00455 WP_001017131.1 81145..82188(+) (vraS) [Staphylococcus aureus strain GE-MSSA31]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=819172 QAY78_RS00455 WP_001017131.1 81145..82188(+) (vraS) [Staphylococcus aureus strain GE-MSSA31]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1