Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   QBL76_RS09685 Genome accession   NZ_CP122304
Coordinates   2057986..2059272 (-) Length   428 a.a.
NCBI ID   WP_010737045.1    Uniprot ID   A0A2A4DST9
Organism   Enterococcus hirae strain DSM 20160     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2019558..2065212 2057986..2059272 within 0


Gene organization within MGE regions


Location: 2019558..2065212
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QBL76_RS09510 (QBL76_09510) - 2019812..2021125 (+) 1314 WP_010737017.1 NCS2 family permease -
  QBL76_RS09515 (QBL76_09515) - 2021392..2023017 (+) 1626 WP_279450748.1 alpha-glucosidase -
  QBL76_RS09520 (QBL76_09520) - 2023084..2023545 (+) 462 WP_231450392.1 LytTR family DNA-binding domain-containing protein -
  QBL76_RS09525 (QBL76_09525) - 2023644..2024060 (+) 417 WP_279450750.1 DUF3021 family protein -
  QBL76_RS09530 (QBL76_09530) - 2024064..2024501 (+) 438 WP_010737021.1 hypothetical protein -
  QBL76_RS09535 (QBL76_09535) - 2024927..2025361 (+) 435 WP_279450752.1 MarR family transcriptional regulator -
  QBL76_RS09540 (QBL76_09540) - 2025441..2026547 (+) 1107 WP_279450755.1 NADH-dependent flavin oxidoreductase -
  QBL76_RS09545 (QBL76_09545) - 2026583..2027260 (+) 678 WP_088745589.1 type 1 glutamine amidotransferase domain-containing protein -
  QBL76_RS09550 (QBL76_09550) - 2027793..2028122 (+) 330 WP_231437168.1 hypothetical protein -
  QBL76_RS09555 (QBL76_09555) - 2028140..2028610 (+) 471 WP_279450758.1 hypothetical protein -
  QBL76_RS09560 (QBL76_09560) - 2028991..2029500 (+) 510 WP_231450390.1 hypothetical protein -
  QBL76_RS09565 (QBL76_09565) - 2029750..2031045 (+) 1296 WP_160231809.1 FAD-dependent oxidoreductase -
  QBL76_RS09570 (QBL76_09570) - 2031035..2032495 (+) 1461 WP_279450765.1 helix-turn-helix domain-containing protein -
  QBL76_RS09575 (QBL76_09575) glpK 2032608..2034104 (+) 1497 WP_279450767.1 glycerol kinase GlpK -
  QBL76_RS09580 (QBL76_09580) glpO 2034119..2035942 (+) 1824 WP_279450769.1 type 1 glycerol-3-phosphate oxidase -
  QBL76_RS09585 (QBL76_09585) - 2035943..2036659 (+) 717 WP_088774960.1 MIP/aquaporin family protein -
  QBL76_RS09590 (QBL76_09590) - 2037171..2039069 (+) 1899 WP_263746085.1 endonuclease MutS2 -
  QBL76_RS09595 (QBL76_09595) - 2039273..2039821 (+) 549 Protein_1844 CDP-alcohol phosphatidyltransferase family protein -
  QBL76_RS09600 (QBL76_09600) - 2039963..2040274 (-) 312 WP_010720957.1 DsrE family protein -
  QBL76_RS09605 (QBL76_09605) - 2040287..2040547 (-) 261 WP_010737033.1 metal-sensitive transcriptional regulator -
  QBL76_RS09610 (QBL76_09610) - 2040719..2041030 (+) 312 WP_181915136.1 rhodanese-like domain-containing protein -
  QBL76_RS09615 (QBL76_09615) - 2041031..2042686 (+) 1656 WP_263746090.1 FAD-dependent oxidoreductase -
  QBL76_RS09620 (QBL76_09620) - 2042762..2044897 (+) 2136 WP_088745599.1 UvrD-helicase domain-containing protein -
  QBL76_RS09625 (QBL76_09625) - 2045191..2045724 (+) 534 WP_088745600.1 hypothetical protein -
  QBL76_RS09630 (QBL76_09630) - 2045699..2047003 (+) 1305 WP_263746094.1 glycosyltransferase family 2 protein -
  QBL76_RS09635 (QBL76_09635) - 2047193..2049063 (+) 1871 Protein_1852 glycosyltransferase -
  QBL76_RS09640 (QBL76_09640) - 2049128..2050006 (-) 879 WP_088745601.1 cation diffusion facilitator family transporter -
  QBL76_RS09645 (QBL76_09645) - 2050056..2051009 (-) 954 WP_002325884.1 IS30 family transposase -
  QBL76_RS09650 (QBL76_09650) - 2051368..2052825 (+) 1458 WP_088745602.1 NAD-dependent succinate-semialdehyde dehydrogenase -
  QBL76_RS09655 (QBL76_09655) - 2052901..2053857 (-) 957 WP_263746097.1 glycosyltransferase family 2 protein -
  QBL76_RS09660 (QBL76_09660) - 2054029..2054382 (-) 354 WP_002317104.1 PepSY domain-containing protein -
  QBL76_RS09665 (QBL76_09665) pepA 2054581..2055660 (+) 1080 WP_010720947.1 glutamyl aminopeptidase -
  QBL76_RS09670 (QBL76_09670) - 2056197..2056517 (+) 321 WP_088745834.1 thioredoxin family protein -
  QBL76_RS09675 (QBL76_09675) - 2056547..2057014 (+) 468 WP_002317107.1 universal stress protein -
  QBL76_RS09680 (QBL76_09680) ytpR 2057323..2057928 (+) 606 WP_010737044.1 YtpR family tRNA-binding protein -
  QBL76_RS09685 (QBL76_09685) htrA 2057986..2059272 (-) 1287 WP_010737045.1 trypsin-like peptidase domain-containing protein Regulator
  QBL76_RS09690 (QBL76_09690) rlmH 2059725..2060204 (+) 480 WP_002317110.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  QBL76_RS09695 (QBL76_09695) - 2060330..2061283 (+) 954 WP_002325884.1 IS30 family transposase -
  QBL76_RS09700 (QBL76_09700) - 2061451..2063394 (+) 1944 WP_010725931.1 PRD domain-containing protein -
  QBL76_RS09705 (QBL76_09705) - 2063396..2063857 (+) 462 WP_088775426.1 PTS sugar transporter subunit IIA -

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44581.68 Da        Isoelectric Point: 4.7976

>NTDB_id=815047 QBL76_RS09685 WP_010737045.1 2057986..2059272(-) (htrA) [Enterococcus hirae strain DSM 20160]
MERKDVTPKMKKNNGIWRKLGLGLVGGIIGGLVTAGIFYAVMGSGNAASNSGGHQNSAGETVVENVKVNVDSDITNAVDK
VQDAVVSVINLQSQNQGTNGFGQLFGQQQQESSDDSNLEASSEGSGVIYKKSGNSAYIVTNNHVVEGQQGLEVLLKDGTK
VKAELVGTDAYSDLAVLKISADKVNKVASFGDSNSLKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNQTVN
INAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSASSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITM
VDLSAVSTQQQEQILKIPESVTNGVIVTSVQPATPAEKAGLKQYDVITKIDDTDVSSGVELQSVLYQKKVGDSVKVTYYR
GKEKKTTTIQLTIDQSALKQSQSENSGN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=815047 QBL76_RS09685 WP_010737045.1 2057986..2059272(-) (htrA) [Enterococcus hirae strain DSM 20160]
ATGGAGAGAAAAGATGTGACACCAAAAATGAAAAAGAATAATGGTATCTGGCGTAAGCTGGGTCTAGGCTTAGTCGGTGG
AATTATTGGGGGCTTGGTAACGGCTGGTATTTTTTATGCTGTCATGGGTTCTGGAAACGCAGCGTCAAATTCGGGTGGTC
ATCAAAATTCAGCGGGCGAAACTGTCGTTGAAAATGTCAAAGTCAATGTCGATTCAGATATTACGAATGCGGTCGATAAA
GTCCAAGATGCGGTGGTATCTGTTATCAATCTTCAAAGCCAAAATCAAGGGACCAACGGCTTTGGGCAACTGTTTGGTCA
ACAACAACAAGAAAGTTCTGATGATAGCAATCTAGAGGCTTCTAGTGAAGGTAGTGGTGTCATCTACAAAAAAAGTGGTA
ATTCCGCTTATATCGTAACGAATAATCACGTAGTGGAAGGACAACAAGGATTAGAAGTTTTATTAAAAGATGGAACAAAA
GTCAAAGCTGAATTAGTCGGGACGGATGCTTATTCTGACTTAGCCGTTTTGAAAATCAGTGCAGATAAAGTGAACAAAGT
TGCTTCATTTGGTGACTCTAATTCATTGAAAGTAGGTGAACCTGCGATCGCAATTGGTTCTCCTCTAGGTTCTGAATATG
CCAACTCTGTGACTTCGGGGATTATCTCATCATTGAATCGCCAAGTAACCAGCACGAACGAGTCAAATCAAACGGTCAAT
ATCAATGCGATCCAAACAGATGCTGCGATTAACCCCGGTAATTCTGGTGGTCCATTAGTTAATATTGAAGGACAAGTAAT
CGGGATCAATTCAAGTAAAATTGCAAGTACTTCTGCTTCTTCATCAGGTGTAAGCGTGGAAGGAATGGGCTTTGCGATCC
CAAGTAACGATGTAGTAAATATTATCAACCAACTTGAAAAAGATGGAAAAGTAACCCGTCCTGCTCTAGGGATCACAATG
GTTGACCTTTCAGCCGTTTCAACCCAACAACAAGAACAAATCTTGAAAATTCCTGAGTCTGTGACAAATGGTGTGATTGT
TACCAGCGTTCAACCGGCGACACCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTCATTACAAAAATCGATGATACTG
ATGTTTCTTCTGGTGTAGAATTACAATCTGTCTTGTATCAGAAAAAAGTCGGCGATTCAGTGAAGGTCACTTACTATCGC
GGAAAAGAAAAGAAAACAACAACAATTCAATTAACAATTGATCAATCCGCATTAAAACAAAGCCAATCAGAGAACTCTGG
TAACTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(124-269)

PDZ domain (PDZ_2)

(314-411)

Peptidase family M50 (Peptidase_M50)

(12-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2A4DST9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

54.545

92.523

0.505
  htrA Streptococcus gordonii str. Challis substr. CH1

53.35

94.159

0.502
  htrA Streptococcus pneumoniae Rx1

58.457

78.738

0.46
  htrA Streptococcus pneumoniae D39

58.457

78.738

0.46
  htrA Streptococcus pneumoniae R6

58.457

78.738

0.46
  htrA Streptococcus pneumoniae TIGR4

58.457

78.738

0.46
  htrA Streptococcus mitis NCTC 12261

57.567

78.738

0.453