Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   QA712_RS06960 Genome accession   NZ_CP121539
Coordinates   1268805..1270031 (+) Length   408 a.a.
NCBI ID   WP_012898631.1    Uniprot ID   Q66RU3
Organism   Lactococcus lactis strain MA5     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1263805..1275031
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QA712_RS06935 (QA712_06935) - 1264895..1265698 (-) 804 WP_003130590.1 phosphatidate cytidylyltransferase -
  QA712_RS06940 (QA712_06940) - 1265698..1266432 (-) 735 WP_003130589.1 isoprenyl transferase -
  QA712_RS06945 (QA712_06945) yajC 1266806..1267138 (-) 333 WP_003130588.1 preprotein translocase subunit YajC -
  QA712_RS06950 (QA712_06950) - 1267233..1267931 (-) 699 WP_153242317.1 DNA alkylation repair protein -
  QA712_RS06955 (QA712_06955) rlmH 1267950..1268429 (-) 480 WP_332529360.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  QA712_RS06960 (QA712_06960) htrA 1268805..1270031 (+) 1227 WP_012898631.1 S1C family serine protease Regulator
  QA712_RS06965 (QA712_06965) - 1270157..1271155 (+) 999 WP_153242318.1 glycosyltransferase family 4 protein -
  QA712_RS06970 (QA712_06970) - 1271281..1272621 (+) 1341 WP_012898632.1 glycosyltransferase family 4 protein -
  QA712_RS06975 (QA712_06975) - 1272729..1272953 (+) 225 WP_003130579.1 YkuJ family protein -
  QA712_RS06980 (QA712_06980) - 1273093..1274097 (+) 1005 WP_047206979.1 hypothetical protein -
  QA712_RS06985 (QA712_06985) - 1274138..1274890 (-) 753 WP_010906333.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -

Sequence

Protein


Download         Length: 408 a.a.        Molecular weight: 41637.93 Da        Isoelectric Point: 4.9794

>NTDB_id=812874 QA712_RS06960 WP_012898631.1 1268805..1270031(+) (htrA) [Lactococcus lactis strain MA5]
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQSANNSRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKDNS
QSSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKASVVGYDEYTDLAV
LKISSEHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSG
GALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGIRMVDLSQLSTNDSSQLKLPS
SVTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLE
TSSSSSSN

Nucleotide


Download         Length: 1227 bp        

>NTDB_id=812874 QA712_RS06960 WP_012898631.1 1268805..1270031(+) (htrA) [Lactococcus lactis strain MA5]
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACAGGTGTCGTGGGCGGAGCCATCGCACTTGGAGGAAGTGCAATCTA
TCAAAGCACTACAAATCAATCGGCAAATAATAGTCGTTCAAATACAACTAGTACAAAGGTTAGTAACGTTTCGGTAAATG
TCAATACTGATGTTACCTCTGCAATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAAGATAACTCA
CAAAGTAGTGACTTCAGTTCAATTTTTGGTGGAAATAGCGGTTCAAGTTCATCGACTGATGGCTTACAGCTTTCTAGTGA
AGGCTCTGGTGTCATCTACAAAAAATCTGGTGGAGATGCCTACGTTGTAACTAACTACCACGTTATTGCTGGTAATAGCT
CACTTGATGTTCTGCTTTCTGGTGGACAAAAAGTCAAAGCTTCTGTGGTTGGTTATGATGAATACACGGACCTTGCTGTT
CTTAAAATCAGTTCTGAACATGTCAAAGATGTGGCGACATTCGCTGATTCTAGTAAATTAACAATCGGTGAACCTGCCAT
TGCCGTTGGCTCACCTTTAGGTAGTCAATTTGCTAACACCGCAACTGAAGGAATTTTATCTGCAACAAGCCGTCAAGTGA
CTTTGACCCAAGAAAATGGTCAAACAACTAATATCAATGCAATTCAAACAGATGCTGCCATTAACCCTGGTAACTCTGGA
GGGGCTTTGATTAATATTGAAGGGCAAGTTATTGGAATTACTCAAAGTAAAATTACAACAACTGAAGACGGTTCTACTTC
TGTCGAAGGTTTAGGATTTGCGATTCCTTCTAACGATGTCGTAAATATCATTAATAAACTTGAAGCTGATGGTAAGATTT
CACGCCCTGCTTTAGGTATCCGAATGGTTGACCTTTCACAATTATCAACAAATGACAGTTCACAATTAAAATTACCAAGT
AGTGTAACAGGTGGGGTTGTTGTTTACTCCGTCCAATCTGGACTTCCTGCTGCCTCAGCTGGTTTGAAAGCTGGAGATGT
AATTACAAAGGTTGGCGATACAGCAGTAACTTCTTCAACAGACTTGCAAAGTGCTCTTTACTCACACAACATCAACGATA
CAGTAAAAGTTACTTATTATCGTGATGGTAAATCAAATACAGCAGATGTTAAACTTTCTAAATCAACCAGTGACTTAGAA
ACAAGCAGTTCATCTTCTTCTAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(296-392)

Peptidase family M50 (Peptidase_M50)

(250-396)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q66RU3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

56.283

93.627

0.527
  htrA Streptococcus gordonii str. Challis substr. CH1

54.476

95.833

0.522
  htrA Streptococcus pneumoniae D39

58.309

84.069

0.49
  htrA Streptococcus pneumoniae TIGR4

58.309

84.069

0.49
  htrA Streptococcus pneumoniae R6

58.309

84.069

0.49
  htrA Streptococcus pneumoniae Rx1

58.309

84.069

0.49
  htrA Streptococcus mutans UA159

52.989

90.196

0.478