Detailed information NTG0811354

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: P8191_RS07565
• Genome accession: NZ_CP121250
• Coordinates: 1436151..1437374 (-)
• Length: 407 a.a.
• NCBI ID: WP_002994926.1
• Uniprot ID: A0A4U9TAA9
• Organism: Streptococcus pyogenes strain 1044
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1431151..1442374

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P8191_RS07545 (P8191_07545)	-	1432135..1432332 (-)	198	WP_002981933.1	DUF951 family protein	-
P8191_RS07550 (P8191_07550)	dnaN	1432407..1433543 (-)	1137	WP_010921762.1	DNA polymerase III subunit beta	-
P8191_RS07555 (P8191_07555)	dnaA	1433698..1435053 (-)	1356	WP_002987659.1	chromosomal replication initiator protein DnaA	-
P8191_RS07560 (P8191_07560)	spo0J	1435286..1436062 (-)	777	WP_014407987.1	ParB/RepB/Spo0J family partition protein	Regulator
P8191_RS07565 (P8191_07565)	htrA	1436151..1437374 (-)	1224	WP_002994926.1	trypsin-like peptidase domain-containing protein	Regulator
P8191_RS07570 (P8191_07570)	rlmH	1437586..1438065 (+)	480	WP_002981964.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
P8191_RS07580 (P8191_07580)	-	1438460..1439224 (+)	765	Protein_1454	IS30 family transposase	-

Sequence

Protein

• Length: 407 a.a.
• Molecular weight: 42760.38 Da
• Isoelectric Point: 7.3920

>NTDB_id=811354 P8191_RS07565 WP_002994926.1 1436151..1437374(-) (htrA) [Streptococcus pyogenes strain 1044]
MPSMKHILKSLSILLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS
SLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA
VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ
INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT
QDLTKTQ

Nucleotide

• Length: 1224 bp

>NTDB_id=811354 P8191_RS07565 WP_002994926.1 1436151..1437374(-) (htrA) [Streptococcus pyogenes strain 1044]
ATGCCAAGTATGAAACATATCTTAAAATCCTTAAGTATTTTACTAATTGGATTTTTAGGAGGATTAATAGCAATTATTAC
ATTCAATAATCTCTACCCACATTCTCCATCAAAAATAAATTCAGGTAAGGCAACAACTAGTAATATGGTTTTTAACAACA
CAACCAATACTACTAAAGCTGTCAAAGCTGTTCAAAATGCAGTTGTATCAGTTATTAATTATCAAGATAACCCTTCTTCA
TCCCTTTCTAACCCTTATACAAAACTCTTTGGAGAAGGGCGTTCAAAAGAGAATAAGGATGCTGAATTATCTATTTTTAG
TGAAGGATCTGGGGTCATTTATCGAAAAGATGGCAACTCCGCTTACGTTGTTACTAATAACCATGTTATCGACGGAGCTA
AACGAATTGAAATTCTTATGGCAGACGGATCTAAAGTTGTTGGTGAATTAGTTGGAGCTGATACTTATTCGGATTTAGCT
GTTGTTAAGATCTCTTCAGATAAGATAAAAACAGTAGCTGAATTTGCAGATTCTACAAAACTAAATGTTGGAGAAGTTGC
TATTGCTATCGGCAGCCCACTAGGAACACAATACGCTAATTCTGTTACTCAAGGAATCGTCTCTAGTTTAAGTCGTACTG
TAACTTTAAAAAACGAGAATGGTGAGACTGTCTCAACAAATGCTATTCAGACAGATGCTGCTATTAACCCTGGAAACTCT
GGTGGACCACTAATTAATATTGAGGGGCAAGTAATCGGAATTAATTCAAGTAAAATTTCTTCTACCCCAACTGGTAGCAA
CGGTAATAGTGGTGCTGTTGAAGGAATTGGTTTTGCTATCCCATCTACTGATGTTATTAAAATTATTAAACAACTAGAAA
CTAATGGTGAAGTTATCAGACCTGCTCTTGGAATATCCATGGTCAATTTAAATGACTTATCCACAAATGCTCTTAGTCAA
ATTAATATTCCAACTAGTGTAACTGGTGGTATTGTAGTAGCAGAAGTTAAGGAAGGAATGCCGGCATCTGGCAAACTTGC
TCAGTACGATGTGATTACAGAAATTGATGGCAAAACAGTTAATTCAATTAGTGATTTACAAAGTAGTCTATACGGACACG
ATATTAATGATACTATTAAAGTAACTTTTTATAGAGGAACTACAAAGAAAAAAGCAGATATCAAATTAACAAAAACTACT
CAAGATTTGACTAAAACGCAGTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (109-254)

• PDZ domain (PDZ_2) (301-396)

3D structure

• AlphaFold DB: A0A4U9TAA9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	61.881	99.263	0.614
htrA	Streptococcus gordonii str. Challis substr. CH1	55.224	98.771	0.545
htrA	Streptococcus mitis NCTC 12261	53.071	100	0.531
htrA	Streptococcus pneumoniae Rx1	52.826	100	0.528
htrA	Streptococcus pneumoniae D39	52.826	100	0.528
htrA	Streptococcus pneumoniae R6	52.826	100	0.528
htrA	Streptococcus pneumoniae TIGR4	52.826	100	0.528