Detailed information NTG0811001

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: P7F70_RS06925
• Genome accession: NZ_CP121201
• Coordinates: 1389251..1389967 (-)
• Length: 238 a.a.
• NCBI ID: WP_104968219.1
• Uniprot ID: A0A2L0D503
• Organism: Streptococcus pluranimalium strain SP28
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1384251..1394967

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P7F70_RS06905 (P7F70_06910)	pstA	1384869..1385684 (-)	816	WP_278023830.1	phosphate ABC transporter permease PstA	-
P7F70_RS06910 (P7F70_06915)	pstC	1385677..1386537 (-)	861	WP_278023832.1	phosphate ABC transporter permease subunit PstC	-
P7F70_RS06915 (P7F70_06920)	-	1386816..1387697 (-)	882	WP_218653483.1	substrate-binding domain-containing protein	-
P7F70_RS06920 (P7F70_06925)	-	1387911..1389251 (-)	1341	WP_278023834.1	ATP-binding protein	-
P7F70_RS06925 (P7F70_06930)	vicR	1389251..1389967 (-)	717	WP_104968219.1	response regulator transcription factor	Regulator
P7F70_RS06930 (P7F70_06935)	-	1390104..1390906 (-)	803	Protein_1316	aldo/keto reductase	-
P7F70_RS06935 (P7F70_06940)	-	1391248..1391763 (+)	516	WP_104968221.1	RNA polymerase sigma factor	-
P7F70_RS06940 (P7F70_06945)	-	1391741..1392712 (+)	972	WP_278023835.1	anti sigma factor C-terminal domain-containing protein	-
P7F70_RS06945 (P7F70_06950)	-	1392771..1392914 (+)	144	WP_278023836.1	DUF4298 domain-containing protein	-
P7F70_RS06950 (P7F70_06955)	-	1393290..1393568 (+)	279	WP_278023837.1	hypothetical protein	-
P7F70_RS06955 (P7F70_06960)	-	1393623..1394669 (-)	1047	WP_278023839.1	LLM class flavin-dependent oxidoreductase	-

Sequence

Protein

• Length: 238 a.a.
• Molecular weight: 27528.83 Da
• Isoelectric Point: 5.4806

>NTDB_id=811001 P7F70_RS06925 WP_104968219.1 1389251..1389967(-) (vicR) [Streptococcus pluranimalium strain SP28]
MQKRVLIVDDEPHILTLVSYHLAKEGFEVTTVEDGRSALELGQGQPFDFIVLDIMLPQLDGVEVCKRLRKAGIETPILML
SAKGEEFDKVLALELGADDYMTKPFSPRELLARIKAILRRTEKNQLSELLQEEDQSDTKFQVADLTVYLERHQIYKADRE
ISLTPKEFELLVYLLKHPRMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPAIIKTVRGYGYKFEGDK

Nucleotide

• Length: 717 bp

>NTDB_id=811001 P7F70_RS06925 WP_104968219.1 1389251..1389967(-) (vicR) [Streptococcus pluranimalium strain SP28]
ATGCAAAAGCGTGTTTTAATCGTGGATGATGAGCCACATATTCTCACTTTGGTTTCCTACCATTTAGCTAAGGAAGGTTT
TGAGGTAACGACTGTCGAAGATGGTCGGTCTGCCCTAGAATTGGGACAAGGTCAGCCCTTTGATTTTATTGTTTTAGATA
TCATGTTGCCACAACTTGATGGTGTTGAAGTTTGTAAAAGACTGCGAAAAGCCGGTATCGAAACCCCTATCCTCATGCTG
TCAGCTAAGGGAGAGGAATTTGATAAGGTTTTAGCTCTGGAATTAGGGGCGGATGACTACATGACCAAGCCCTTTAGTCC
GCGGGAACTTCTGGCTAGGATCAAGGCAATCCTGCGTCGGACTGAGAAAAATCAACTGTCAGAATTGCTCCAAGAAGAAG
ACCAGTCTGATACGAAATTTCAAGTTGCAGACTTAACGGTCTATTTGGAGCGTCATCAGATTTACAAGGCAGATCGAGAG
ATTAGCTTGACGCCTAAAGAGTTTGAACTCTTGGTTTATCTTTTGAAGCATCCTCGTATGACGCTGACCAGAGAACGCCT
GTTGGAGCGGATTTGGGGCTATGATTTTGGGCAGGAGACCCGTTTAGTGGATGTGCATATCGGTAAGTTACGTGAAAAAA
TCGAGGATAATCCCAAGGCACCTGCCATTATCAAAACAGTCAGAGGTTACGGCTACAAGTTTGAAGGAGACAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (159-234)

3D structure

• AlphaFold DB: A0A2L0D503

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	50.435	96.639	0.487
micA	Streptococcus pneumoniae Cp1015	50	96.639	0.483
covR	Streptococcus salivarius strain HSISS4	42.241	97.479	0.412
covR	Lactococcus lactis subsp. lactis strain DGCC12653	41.126	97.059	0.399
scnR	Streptococcus mutans UA159	37.021	98.739	0.366