Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   P8R99_RS01335 Genome accession   NZ_CP121160
Coordinates   229560..230240 (+) Length   226 a.a.
NCBI ID   WP_278043326.1    Uniprot ID   -
Organism   Streptococcus agalactiae strain S5     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 224560..235240
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P8R99_RS01320 pstB 225258..226016 (+) 759 WP_000193363.1 phosphate ABC transporter ATP-binding protein PstB -
  P8R99_RS01325 phoU 226050..226703 (+) 654 WP_000946330.1 phosphate signaling complex protein PhoU -
  P8R99_RS01330 - 226849..229398 (+) 2550 WP_000859375.1 M1 family metallopeptidase -
  P8R99_RS01335 ciaR 229560..230240 (+) 681 WP_278043326.1 response regulator transcription factor Regulator
  P8R99_RS01340 ciaH 230224..231537 (+) 1314 WP_000042576.1 HAMP domain-containing sensor histidine kinase Regulator
  P8R99_RS01345 - 231626..231958 (+) 333 WP_000402075.1 putative DNA-binding protein -
  P8R99_RS01350 ffh 231976..233541 (+) 1566 WP_000863591.1 signal recognition particle protein -
  P8R99_RS01355 - 233608..234294 (+) 687 WP_000280308.1 SatD family protein -
  P8R99_RS01360 - 234284..235057 (+) 774 WP_000622403.1 DUF3307 domain-containing protein -

Sequence

Protein


Download         Length: 226 a.a.        Molecular weight: 25818.61 Da        Isoelectric Point: 4.2507

>NTDB_id=810649 P8R99_RS01335 WP_278043326.1 229560..230240(+) (ciaR) [Streptococcus agalactiae strain S5]
MIKILLIEDDLSLSNSVFDLLDDFADVMQIFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESIDDKGQGFDLGADDYLTKPFYLEELKMRIQALLKRSGKFNDNSLIYGDIRVDMSTNSTFVNQTEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKVRKKLKGTLFSENLQTLRSVGYILKHVETD

Nucleotide


Download         Length: 681 bp        

>NTDB_id=810649 P8R99_RS01335 WP_278043326.1 229560..230240(+) (ciaR) [Streptococcus agalactiae strain S5]
ATGATAAAAATTTTATTAATTGAAGATGACTTGAGTCTTTCCAATTCCGTTTTTGATTTACTTGATGACTTTGCCGATGT
CATGCAAATTTTTGATGGAGAAGAGGGTCTTTACGAAGCCGAAAGTGGAGTCTATGATCTGATTCTTCTAGATCTCATGT
TACCTGAAAAAAACGGCTTCCAAGTGTTGAAAGAGCTACGTGAAAAAGGTATTACAACCCCTGTATTAATAATGACCGCT
AAAGAAAGCATTGATGATAAGGGACAAGGTTTCGACTTAGGTGCTGATGATTATCTAACAAAACCTTTTTACCTAGAAGA
ACTAAAAATGCGAATTCAGGCTCTTTTAAAGCGTTCTGGAAAATTTAATGATAACAGCCTAATTTATGGTGATATTCGCG
TAGACATGTCTACTAACTCAACCTTTGTTAATCAAACAGAAGTTGAGCTCTTAGGTAAAGAGTTTGATCTTTTAGTCTAT
TTCCTTCAAAATCAAAATGTTATCTTACCGAAATCTCAAATCTTTGATCGTATTTGGGGATTTGATAGTGATACAACGAT
TTCAGTTGTAGAAGTTTATGTCTCTAAGGTTCGGAAAAAATTAAAAGGAACACTTTTTTCAGAAAACCTTCAAACTTTGC
GTAGTGTAGGATATATTTTAAAGCATGTCGAAACCGATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

87.946

99.115

0.872
  ciaR Streptococcus pneumoniae D39

87.946

99.115

0.872
  ciaR Streptococcus pneumoniae R6

87.946

99.115

0.872
  ciaR Streptococcus pneumoniae Rx1

87.946

99.115

0.872
  ciaR Streptococcus mutans UA159

88.235

97.788

0.863
  vicR Streptococcus mutans UA159

35.622

100

0.367
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.607

99.115

0.363