Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   P8R98_RS01165 Genome accession   NZ_CP121159
Coordinates   191662..192891 (-) Length   409 a.a.
NCBI ID   WP_000728357.1    Uniprot ID   A0AAD2WWM9
Organism   Streptococcus agalactiae strain S1     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 140367..191564 191662..192891 flank 98


Gene organization within MGE regions


Location: 140367..192891
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P8R98_RS00830 - 140367..141671 (-) 1305 WP_000783412.1 LysM peptidoglycan-binding domain-containing protein -
  P8R98_RS00835 - 141818..142717 (-) 900 WP_001045909.1 lytic exoenzyme target recognition domain-containing protein -
  P8R98_RS00840 purH 142910..144457 (-) 1548 WP_000166562.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  P8R98_RS00845 - 144477..145229 (-) 753 WP_000780014.1 GNAT family N-acetyltransferase -
  P8R98_RS00850 purN 145252..145803 (-) 552 WP_000717515.1 phosphoribosylglycinamide formyltransferase -
  P8R98_RS00855 purM 146066..147091 (-) 1026 WP_001293628.1 phosphoribosylformylglycinamidine cyclo-ligase -
  P8R98_RS00860 purF 147119..148573 (-) 1455 WP_000220676.1 amidophosphoribosyltransferase -
  P8R98_RS00865 - 148807..152532 (-) 3726 WP_001042259.1 phosphoribosylformylglycinamidine synthase -
  P8R98_RS00870 purC 152655..153359 (-) 705 WP_001064658.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  P8R98_RS00875 - 153483..153722 (-) 240 WP_000085641.1 phosphopantetheine-binding protein -
  P8R98_RS00880 plsX 153733..154725 (-) 993 WP_000717409.1 phosphate acyltransferase PlsX -
  P8R98_RS00885 - 154803..155681 (-) 879 WP_000420130.1 type II CAAX endopeptidase family protein -
  P8R98_RS00890 recO 155744..156505 (-) 762 WP_001266269.1 DNA repair protein RecO -
  P8R98_RS00895 - 156495..157670 (-) 1176 WP_000171460.1 pyridoxal phosphate-dependent aminotransferase -
  P8R98_RS00900 - 157778..158746 (-) 969 WP_000122450.1 ribose-phosphate diphosphokinase -
  P8R98_RS00905 - 158870..160171 (-) 1302 WP_000746073.1 peptidoglycan hydrolase PcsB -
  P8R98_RS01075 ftsH 173158..175134 (-) 1977 WP_000794527.1 ATP-dependent zinc metalloprotease FtsH -
  P8R98_RS01080 hpt 175157..175699 (-) 543 WP_000892188.1 hypoxanthine phosphoribosyltransferase -
  P8R98_RS01085 tilS 175704..176978 (-) 1275 WP_278043476.1 tRNA lysidine(34) synthetase TilS -
  P8R98_RS01090 - 176980..178266 (-) 1287 WP_000757205.1 serine hydrolase -
  P8R98_RS01095 - 178266..178400 (-) 135 WP_001061058.1 SP_0009 family protein -
  P8R98_RS01100 - 178403..178774 (-) 372 WP_000042844.1 septum formation initiator family protein -
  P8R98_RS01105 - 178761..179033 (-) 273 WP_001234967.1 RNA-binding S4 domain-containing protein -
  P8R98_RS01110 - 179139..180593 (-) 1455 WP_031463828.1 IS1182-like element IS1563 family transposase -
  P8R98_RS01115 mfd 180883..184380 (-) 3498 WP_001021187.1 transcription-repair coupling factor -
  P8R98_RS01120 pth 184377..184952 (-) 576 WP_161501758.1 aminoacyl-tRNA hydrolase -
  P8R98_RS01125 ychF 185036..186151 (-) 1116 WP_001218689.1 redox-regulated ATPase YchF -
  P8R98_RS01130 - 186311..186514 (-) 204 WP_001871843.1 hypothetical protein -
  P8R98_RS01135 - 186507..186647 (-) 141 WP_001871845.1 helix-turn-helix transcriptional regulator -
  P8R98_RS01140 - 186772..186969 (-) 198 WP_000285199.1 DUF951 family protein -
  P8R98_RS01145 - 186979..187872 (-) 894 WP_000987440.1 diacylglycerol kinase family protein -
  P8R98_RS01150 dnaN 187930..189066 (-) 1137 WP_000581134.1 DNA polymerase III subunit beta -
  P8R98_RS01155 dnaA 189221..190582 (-) 1362 WP_000138202.1 chromosomal replication initiator protein DnaA -
  P8R98_RS01160 spo0J 190791..191564 (-) 774 WP_278043477.1 ParB/RepB/Spo0J family partition protein Regulator
  P8R98_RS01165 htrA 191662..192891 (-) 1230 WP_000728357.1 trypsin-like peptidase domain-containing protein Regulator

Sequence

Protein


Download         Length: 409 a.a.        Molecular weight: 43090.54 Da        Isoelectric Point: 9.5271

>NTDB_id=810603 P8R98_RS01165 WP_000728357.1 191662..192891(-) (htrA) [Streptococcus agalactiae strain S1]
MKKKLVSSLLKCSLIIIVSFAGGAFASFVMNHNDNIPNGGVTKTSKVNYNNITPTTKAVKKVQNSVVSVINYKQQESRSD
LSDFYSHFFGNQGGNTDKGLQVYGEGSGVIYKKDGKNAYVVTNNHVIDGAKQIEIQLADGSKAVGKLVGSDTYSDLAVVK
IPSDKVSNIAEFADSSKLNIGETAIAIGSPLGTEYANSVTQGIVSSLKRTVTMTNEEGQTVSTNAIQTDAAINPGNSGGA
LINIEGQVIGINSSKISSTSNQTSGQSSGNSVEGMGFAIPSNDVVKIINQLESNGQVERPALGISMAGLSNLPSDVISKL
KIPSNVTNGIVVASIQSGMPAQGKLKKYDVITKVDDKEVASPSDLQSLLYGHQVGDSITVTFYRGENKQTVTIKLTKTSK
DLAKQRANN

Nucleotide


Download         Length: 1230 bp        

>NTDB_id=810603 P8R98_RS01165 WP_000728357.1 191662..192891(-) (htrA) [Streptococcus agalactiae strain S1]
GTGAAAAAAAAATTAGTCTCATCACTTCTAAAGTGTTCTCTAATCATTATCGTTAGCTTTGCTGGTGGAGCATTTGCTAG
TTTTGTCATGAATCATAATGACAATATTCCAAATGGTGGTGTCACTAAAACTAGTAAAGTAAATTATAATAACATAACGC
CTACAACAAAAGCTGTTAAAAAGGTACAAAATAGTGTTGTTTCTGTTATCAATTATAAACAACAAGAGAGTCGTTCTGAC
CTATCAGACTTCTATAGTCATTTTTTTGGTAATCAGGGGGGCAACACTGATAAGGGCTTACAAGTTTACGGTGAAGGCTC
TGGAGTCATCTATAAAAAAGATGGTAAAAATGCCTATGTTGTCACTAATAACCACGTCATTGATGGGGCTAAACAAATTG
AAATTCAACTAGCTGATGGCTCAAAAGCAGTTGGGAAACTTGTTGGGTCAGATACCTACTCTGATTTAGCCGTCGTCAAA
ATTCCATCAGATAAAGTTTCAAATATTGCAGAATTTGCTGATTCATCAAAACTCAACATTGGTGAAACTGCTATAGCGAT
CGGAAGCCCTCTTGGAACTGAGTATGCAAATTCTGTAACTCAAGGTATTGTATCTAGTTTAAAAAGAACTGTAACAATGA
CTAATGAAGAAGGACAAACAGTTTCTACAAATGCTATCCAGACGGATGCTGCTATCAATCCTGGTAATTCAGGCGGAGCA
CTTATCAATATTGAAGGACAGGTTATTGGAATTAATTCTAGTAAAATTTCTTCTACATCAAATCAAACCTCAGGACAATC
GTCAGGAAATAGCGTTGAAGGTATGGGATTTGCCATTCCTTCAAATGATGTTGTTAAGATTATCAATCAACTTGAGAGTA
ACGGACAAGTAGAGAGACCTGCTCTAGGTATTTCTATGGCTGGATTAAGTAATTTACCATCCGATGTTATTAGTAAACTG
AAAATCCCAAGTAATGTTACTAATGGTATTGTAGTAGCATCTATCCAATCTGGCATGCCAGCTCAAGGCAAACTAAAGAA
ATACGATGTCATTACTAAAGTTGACGATAAAGAAGTAGCATCTCCAAGTGATTTACAAAGTTTACTCTATGGCCACCAGG
TAGGGGATTCCATAACAGTAACCTTTTATCGTGGTGAAAATAAACAAACAGTCACTATAAAACTTACTAAAACTAGTAAA
GATTTAGCTAAACAACGAGCAAATAACTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(106-251)

PDZ domain (PDZ_2)

(300-395)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

63.359

96.088

0.609
  htrA Streptococcus gordonii str. Challis substr. CH1

57.357

98.044

0.562
  htrA Streptococcus mitis NCTC 12261

56.533

97.311

0.55
  htrA Streptococcus pneumoniae TIGR4

55.037

99.511

0.548
  htrA Streptococcus pneumoniae Rx1

55.037

99.511

0.548
  htrA Streptococcus pneumoniae D39

55.037

99.511

0.548
  htrA Streptococcus pneumoniae R6

55.037

99.511

0.548