Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   P3U18_RS10290 Genome accession   NZ_CP120078
Coordinates   2173207..2175357 (-) Length   716 a.a.
NCBI ID   WP_187530420.1    Uniprot ID   -
Organism   Staphylococcus pseudintermedius strain Dog120     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2176199..2240390 2173207..2175357 flank 842


Gene organization within MGE regions


Location: 2173207..2240390
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P3U18_RS10290 (P3U18_10290) comA 2173207..2175357 (-) 2151 WP_187530420.1 peptide cleavage/export ABC transporter Regulator
  P3U18_RS10295 (P3U18_10295) - 2175482..2175664 (-) 183 WP_037543780.1 hypothetical protein -
  P3U18_RS12875 - 2175736..2176014 (-) 279 WP_063279018.1 DUF3884 family protein -
  P3U18_RS10300 (P3U18_10300) - 2176115..2177404 (-) 1290 WP_233276501.1 glycosyltransferase -
  P3U18_RS10305 (P3U18_10305) ltaS 2178990..2180927 (-) 1938 WP_037543783.1 polyglycerol-phosphate lipoteichoic acid synthase LtaS -
  P3U18_RS10310 (P3U18_10310) - 2181272..2182276 (-) 1005 WP_014614543.1 biotin-dependent carboxyltransferase family protein -
  P3U18_RS10315 (P3U18_10315) - 2182273..2182956 (-) 684 WP_037543786.1 allophanate hydrolase subunit 1 -
  P3U18_RS10320 (P3U18_10320) - 2182967..2183176 (-) 210 WP_014614545.1 hypothetical protein -
  P3U18_RS10325 (P3U18_10325) - 2183185..2183799 (-) 615 WP_063279016.1 aminotransferase class IV -
  P3U18_RS10330 (P3U18_10330) - 2183796..2184944 (-) 1149 WP_014614546.1 anthranilate synthase component I family protein -
  P3U18_RS10335 (P3U18_10335) - 2184928..2185521 (-) 594 WP_063279015.1 anthranilate synthase component II -
  P3U18_RS10340 (P3U18_10340) queC 2185782..2186450 (+) 669 WP_014614548.1 7-cyano-7-deazaguanine synthase QueC -
  P3U18_RS10345 (P3U18_10345) queD 2186450..2186881 (+) 432 WP_063279014.1 6-carboxytetrahydropterin synthase QueD -
  P3U18_RS10350 (P3U18_10350) queE 2186874..2187587 (+) 714 WP_014614550.1 7-carboxy-7-deazaguanine synthase QueE -
  P3U18_RS10355 (P3U18_10355) - 2187735..2188334 (+) 600 WP_037543793.1 hypothetical protein -
  P3U18_RS10360 (P3U18_10360) - 2188404..2188658 (+) 255 WP_014614552.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  P3U18_RS10365 (P3U18_10365) - 2188831..2189811 (-) 981 WP_063279013.1 glycosyltransferase family 2 protein -
  P3U18_RS10370 (P3U18_10370) - 2190628..2191983 (-) 1356 WP_014614554.1 hemolysin family protein -
  P3U18_RS10375 (P3U18_10375) - 2192402..2194300 (-) 1899 WP_099987382.1 fructose-specific PTS transporter subunit EIIC -
  P3U18_RS10380 (P3U18_10380) pfkB 2194302..2195225 (-) 924 WP_096636585.1 1-phosphofructokinase -
  P3U18_RS10385 (P3U18_10385) - 2195225..2195977 (-) 753 WP_014614557.1 DeoR/GlpR family DNA-binding transcription regulator -
  P3U18_RS10390 (P3U18_10390) - 2196229..2196447 (+) 219 WP_241539207.1 DUF6007 family protein -
  P3U18_RS10395 (P3U18_10395) - 2196559..2196762 (+) 204 WP_014614559.1 hypothetical protein -
  P3U18_RS10400 (P3U18_10400) - 2196808..2196987 (-) 180 WP_015728727.1 VraH family peptide resistance protein -
  P3U18_RS10405 (P3U18_10405) ybaK 2197137..2197616 (-) 480 WP_014614561.1 Cys-tRNA(Pro) deacylase -
  P3U18_RS10410 (P3U18_10410) - 2197639..2199963 (-) 2325 WP_323699812.1 CDP-glycerol glycerophosphotransferase family protein -
  P3U18_RS10415 (P3U18_10415) norA 2200101..2201267 (-) 1167 WP_323699814.1 multidrug efflux MFS transporter NorA -
  P3U18_RS10420 (P3U18_10420) - 2201585..2202202 (+) 618 WP_020219822.1 DUF1361 domain-containing protein -
  P3U18_RS10425 (P3U18_10425) - 2202512..2203216 (+) 705 WP_225549916.1 CPBP family intramembrane glutamic endopeptidase -
  P3U18_RS10430 (P3U18_10430) mdh 2203347..2204285 (-) 939 WP_014614567.1 malate dehydrogenase -
  P3U18_RS10435 (P3U18_10435) - 2204722..2205249 (-) 528 WP_323701048.1 IS30 family transposase -
  P3U18_RS10440 (P3U18_10440) - 2205230..2205733 (-) 504 WP_114281547.1 helix-turn-helix domain-containing protein -
  P3U18_RS10445 (P3U18_10445) - 2205840..2206193 (-) 354 WP_070407801.1 cystatin-like fold lipoprotein -
  P3U18_RS10450 (P3U18_10450) - 2206243..2206833 (-) 591 WP_110159127.1 hypothetical protein -
  P3U18_RS10455 (P3U18_10455) - 2206838..2207881 (-) 1044 WP_323699819.1 CHAP domain-containing protein -
  P3U18_RS10460 (P3U18_10460) - 2207871..2209757 (-) 1887 WP_323699821.1 CD3337/EF1877 family mobilome membrane protein -
  P3U18_RS10465 (P3U18_10465) - 2209779..2211173 (-) 1395 WP_323699823.1 cell division protein FtsK -
  P3U18_RS10470 (P3U18_10470) - 2211188..2213683 (-) 2496 WP_323699825.1 ATP-binding protein -
  P3U18_RS10475 (P3U18_10475) - 2213718..2214101 (-) 384 WP_323699827.1 TcpE family conjugal transfer membrane protein -
  P3U18_RS10480 (P3U18_10480) - 2214108..2214371 (-) 264 WP_323699829.1 TcpD family membrane protein -
  P3U18_RS10485 (P3U18_10485) - 2214375..2215427 (-) 1053 WP_323701050.1 conjugal transfer protein -
  P3U18_RS10490 (P3U18_10490) - 2215502..2216602 (-) 1101 WP_323699831.1 replication initiation factor domain-containing protein -
  P3U18_RS10495 (P3U18_10495) - 2216765..2217073 (-) 309 WP_323699833.1 hypothetical protein -
  P3U18_RS10500 (P3U18_10500) - 2217088..2217408 (-) 321 WP_019168869.1 DUF961 family protein -
  P3U18_RS10505 (P3U18_10505) - 2217569..2217853 (-) 285 WP_019168868.1 hypothetical protein -
  P3U18_RS10510 (P3U18_10510) - 2218123..2218920 (-) 798 WP_323699836.1 AAA family ATPase -
  P3U18_RS10515 (P3U18_10515) - 2219169..2219450 (-) 282 WP_041614766.1 AAA family ATPase -
  P3U18_RS10520 (P3U18_10520) - 2219638..2219919 (-) 282 WP_014614570.1 hypothetical protein -
  P3U18_RS10525 (P3U18_10525) - 2220002..2220910 (-) 909 WP_015728721.1 aldo/keto reductase family oxidoreductase -
  P3U18_RS10530 (P3U18_10530) - 2220937..2221866 (-) 930 WP_014614572.1 CobW family GTP-binding protein -
  P3U18_RS10535 (P3U18_10535) - 2222098..2222535 (+) 438 WP_014614573.1 MarR family winged helix-turn-helix transcriptional regulator -
  P3U18_RS10540 (P3U18_10540) - 2222921..2224582 (-) 1662 WP_015728719.1 amino acid ABC transporter ATP-binding/permease protein -
  P3U18_RS10545 (P3U18_10545) - 2224583..2226220 (-) 1638 WP_096533139.1 ABC transporter ATP-binding protein/permease -
  P3U18_RS10550 (P3U18_10550) - 2226499..2227353 (+) 855 WP_015728718.1 undecaprenyl-diphosphate phosphatase -
  P3U18_RS10555 (P3U18_10555) - 2227737..2228726 (+) 990 WP_096535854.1 hypothetical protein -
  P3U18_RS10560 (P3U18_10560) - 2228727..2229173 (+) 447 WP_014614578.1 YaiI/YqxD family protein -
  P3U18_RS10565 (P3U18_10565) - 2229274..2229840 (+) 567 WP_031253776.1 TIGR00730 family Rossman fold protein -
  P3U18_RS10570 (P3U18_10570) - 2229857..2230249 (+) 393 WP_000393259.1 GNAT family N-acetyltransferase -
  P3U18_RS10575 (P3U18_10575) aph(2'')-Ia 2230250..2231689 (+) 1440 WP_001028144.1 aminoglycoside O-phosphotransferase APH(2'')-Ia -
  P3U18_RS10580 (P3U18_10580) - 2232564..2233112 (-) 549 WP_014614580.1 GNAT family N-acetyltransferase -
  P3U18_RS10585 (P3U18_10585) - 2233322..2233621 (-) 300 WP_014614581.1 hypothetical protein -
  P3U18_RS10590 (P3U18_10590) - 2233744..2234079 (-) 336 WP_037543809.1 SA0632 family lipoprotein -
  P3U18_RS10595 (P3U18_10595) - 2234149..2234604 (-) 456 WP_014614583.1 GNAT family N-acetyltransferase -
  P3U18_RS10600 (P3U18_10600) - 2234703..2235386 (+) 684 WP_065354534.1 DUF1129 family protein -
  P3U18_RS10605 (P3U18_10605) - 2235471..2235962 (-) 492 WP_015728715.1 DUF456 domain-containing protein -
  P3U18_RS10610 (P3U18_10610) - 2235984..2237189 (-) 1206 WP_014614586.1 sugar efflux transporter -
  P3U18_RS10615 (P3U18_10615) - 2237269..2238138 (-) 870 WP_014614587.1 LysR family transcriptional regulator -
  P3U18_RS10620 (P3U18_10620) - 2238227..2238823 (-) 597 WP_014614588.1 DUF402 domain-containing protein -
  P3U18_RS10625 (P3U18_10625) - 2239146..2239625 (-) 480 WP_015728712.1 cupin domain-containing protein -
  P3U18_RS10630 (P3U18_10630) - 2239644..2240360 (-) 717 WP_014614590.1 YebC/PmpR family DNA-binding transcriptional regulator -

Sequence

Protein


Download         Length: 716 a.a.        Molecular weight: 81641.35 Da        Isoelectric Point: 9.8385

>NTDB_id=802618 P3U18_RS10290 WP_187530420.1 2173207..2175357(-) (comA) [Staphylococcus pseudintermedius strain Dog120]
MKFSKRFYRAQVDSQDCGAAALAMILEFYGSHYSLDFLRRKLRTTVNGTTAYGLVQVADKLGFETVPIKADISLFEIDDV
QYPFIVHVKKNNNHFHYYVVIRCDKKYIYIADPDPVVNLTKMTYREFKEEWTGVTILLKPTSLYKPIKQDKVRLTSFIPL
LLKEKRLIIKIIIISILVNMINILGSYFMKSIIDFYIPQKLKTWVSMISMALIASYIIQQILSYLQKYFLILLVKTYSIN
ILSPYIKHLFRLPITFFETRRAGDILSRLNDANSITDALASTMLSLFLDVTIIVGISIFLYYQSTILFVLILIIIPIYAV
IVFGFMNSFERKRIKSMEANATLSSYLMENITGMETIKALTCEKKCYKQIKYNFSNYYEKTFLLNKLNIKQNVLKKVVQL
ILNVSILWVGANLVIDNQISIGTLLVFNSLVIYFMNPIENIMNLQLKLQIAGVANNRLNEIFTVKSEFEKNKLDIKLNQN
SSKLIFSNISYGYGYEKEILTDINITIEHNSKVAFIGESGSGKTTLAKMMVSFFEPSKGKITLGGLDITNINKSVLRQQI
IYIPQQTYIFNGTILENLLLGVVKEVTQKDIDSAIKMAELKSFIDSLPLGLDSVLSSDFSALSGGQRQKIALARALLTNS
SILIMDEATSNIDILTERKIINNLIALNKTIIFISHNLNITQKVDKIFVLAKGKIIEEGSHEFLLKAKGYYSNLIN

Nucleotide


Download         Length: 2151 bp        

>NTDB_id=802618 P3U18_RS10290 WP_187530420.1 2173207..2175357(-) (comA) [Staphylococcus pseudintermedius strain Dog120]
ATGAAATTTTCAAAACGATTTTATCGTGCACAAGTAGATTCTCAAGATTGTGGCGCGGCAGCGCTCGCTATGATATTAGA
ATTTTACGGTTCTCACTATTCTTTGGATTTTCTGAGAAGAAAGTTAAGAACAACAGTAAATGGCACTACAGCATATGGTT
TGGTTCAGGTAGCAGATAAGTTAGGTTTTGAGACAGTTCCTATTAAAGCAGATATATCTTTGTTTGAAATTGATGATGTA
CAGTATCCTTTTATCGTTCATGTTAAAAAAAATAACAATCATTTTCACTATTATGTTGTAATTAGATGTGATAAAAAGTA
TATCTATATAGCTGACCCTGACCCTGTTGTTAATTTAACAAAGATGACTTATAGGGAATTTAAAGAAGAGTGGACTGGAG
TTACAATCTTATTAAAACCTACATCTTTATATAAACCTATAAAGCAAGATAAAGTTCGTTTAACTTCTTTTATACCTTTA
TTATTAAAAGAAAAAAGGTTGATTATAAAAATAATAATTATTTCCATTTTAGTCAATATGATAAATATTTTAGGTTCATA
TTTTATGAAGTCAATTATTGATTTTTATATTCCGCAAAAGTTAAAAACATGGGTTAGTATGATTTCCATGGCTTTAATTG
CTTCTTACATTATACAACAAATTCTTAGTTATTTGCAGAAATATTTTTTGATTTTATTAGTAAAGACATATTCTATAAAT
ATACTTTCACCATACATTAAACATTTGTTTAGATTACCTATTACTTTTTTTGAAACGAGAAGAGCAGGAGACATACTATC
AAGACTTAATGATGCAAATTCAATTACTGACGCTTTAGCTAGTACCATGCTATCATTGTTTTTAGATGTTACAATAATAG
TTGGAATATCTATCTTCCTGTATTATCAAAGTACTATTTTATTTGTATTAATATTAATTATCATTCCTATTTATGCCGTA
ATTGTTTTTGGTTTTATGAACTCTTTTGAACGGAAAAGAATAAAATCTATGGAGGCAAATGCTACTTTGTCTTCTTATTT
GATGGAAAATATAACAGGTATGGAGACGATAAAAGCACTGACATGTGAAAAGAAATGCTATAAGCAGATAAAATATAATT
TTTCGAATTATTACGAAAAAACATTCTTGTTAAACAAACTAAATATAAAGCAAAATGTTTTGAAAAAGGTTGTTCAATTA
ATATTAAATGTATCGATTTTATGGGTAGGCGCTAACCTAGTTATAGATAATCAAATCTCAATTGGAACTTTGCTTGTTTT
TAATTCATTAGTGATTTACTTTATGAATCCAATAGAAAATATTATGAATTTACAGCTTAAATTACAAATAGCAGGTGTGG
CTAATAATCGATTGAATGAAATATTCACAGTTAAATCAGAATTTGAAAAGAATAAATTGGATATCAAATTGAACCAAAAC
TCAAGTAAACTTATATTTTCAAATATTTCATATGGATATGGGTACGAAAAAGAAATCCTTACAGATATTAATATAACAAT
AGAACATAATAGTAAAGTAGCCTTTATTGGAGAGTCTGGATCAGGTAAAACAACTTTGGCGAAAATGATGGTTAGTTTTT
TTGAACCTTCAAAGGGTAAAATAACACTAGGTGGATTGGACATAACAAATATCAATAAATCTGTTTTACGACAGCAGATT
ATATACATTCCACAACAAACTTATATTTTTAATGGAACTATACTTGAAAATCTTTTATTAGGGGTAGTTAAAGAGGTTAC
GCAAAAGGACATAGATAGTGCTATTAAAATGGCTGAACTAAAATCCTTTATTGATAGCTTACCACTTGGACTTGATAGTG
TATTAAGTTCTGATTTTTCTGCTTTGTCAGGAGGTCAGCGGCAGAAGATAGCTTTAGCAAGAGCACTATTAACAAATTCT
TCTATATTGATAATGGATGAAGCAACGAGTAATATTGATATACTCACGGAGAGAAAAATTATTAATAATTTGATAGCGTT
AAATAAAACTATTATATTTATCTCCCATAATCTAAATATAACTCAAAAAGTAGATAAAATATTTGTTTTAGCAAAAGGAA
AAATTATAGAAGAGGGCTCACATGAATTTTTATTAAAAGCAAAAGGTTACTATTCTAACTTAATTAATTAA

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(169-437)

ABC transporter (ABC_tran)

(500-650)

Peptidase C39 family (Peptidase_C39)

(8-141)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis SK321

53.492

100

0.535
  comA Streptococcus mitis NCTC 12261

53.352

100

0.534
  comA Streptococcus pneumoniae D39

53.212

100

0.532
  comA Streptococcus pneumoniae R6

53.212

100

0.532
  comA Streptococcus pneumoniae Rx1

53.212

100

0.532
  comA Streptococcus gordonii str. Challis substr. CH1

53.212

100

0.532
  comA Streptococcus pneumoniae TIGR4

52.933

100

0.529
  comA/nlmT Streptococcus mutans UA159

49.167

100

0.494