Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   P0083_RS14220 Genome accession   NZ_CP119528
Coordinates   2841273..2842571 (+) Length   432 a.a.
NCBI ID   WP_002387354.1    Uniprot ID   -
Organism   Enterococcus faecalis strain 3143     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2836273..2847571
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P0083_RS14215 (P0083_14215) rlmH 2840393..2840872 (-) 480 WP_002355021.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  P0083_RS14220 (P0083_14220) htrA 2841273..2842571 (+) 1299 WP_002387354.1 trypsin-like peptidase domain-containing protein Regulator
  P0083_RS14225 (P0083_14225) ytpR 2842618..2843238 (-) 621 WP_002361057.1 YtpR family tRNA-binding protein -
  P0083_RS14230 (P0083_14230) - 2843342..2844166 (-) 825 WP_002385250.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
  P0083_RS14235 (P0083_14235) - 2844150..2844920 (-) 771 WP_002359088.1 PTS sugar transporter subunit IIC -
  P0083_RS14240 (P0083_14240) - 2844942..2845415 (-) 474 WP_002359087.1 PTS sugar transporter subunit IIB -
  P0083_RS14245 (P0083_14245) - 2845418..2846161 (-) 744 WP_002387355.1 BtpA/SgcQ family protein -
  P0083_RS14250 (P0083_14250) - 2846173..2846583 (-) 411 WP_002359084.1 PTS sugar transporter subunit IIA -
  P0083_RS14255 (P0083_14255) - 2846598..2847329 (-) 732 WP_010706780.1 GntR family transcriptional regulator -

Sequence

Protein


Download         Length: 432 a.a.        Molecular weight: 44934.04 Da        Isoelectric Point: 4.9047

>NTDB_id=799535 P0083_RS14220 WP_002387354.1 2841273..2842571(+) (htrA) [Enterococcus faecalis strain 3143]
MQRKDVTPNSDKKSLLQKFGIGLAGGLLGGALILGGAYSGIIPTPNGGNNAATTTSTNHGDTKVSNVSYNVSSDVTKAVK
KVQNSVVSVINMQSASNNSSADDPFEGLFGGNEGTQDSSGNNGNDLEAASEGSGVIYKKDGKTAYVVTNNHVVDKAQGLE
VVLSDGTKVKGELVGTDAYTDLAVIKISSDKVDQVAEFGNSSKITVGEPAIAIGSPLGSDYANSVTQGIISSVNRNITNK
NESGETININAIQTDAAINPGNSGGPLINIEGQVIGINSVKIVQSTSQVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPA
LGITMSDLTGISSQQQEQILKIPTSVKTGVVVRGVEAATPAEKAGLEKYDVITKVDGQDVSSTTDLQSALYKKKVGDKME
VTYYRGSKEMKATIDLTIDKSALTQQNNRSNQ

Nucleotide


Download         Length: 1299 bp        

>NTDB_id=799535 P0083_RS14220 WP_002387354.1 2841273..2842571(+) (htrA) [Enterococcus faecalis strain 3143]
ATGCAACGAAAAGATGTTACACCTAATTCAGATAAAAAAAGTTTATTGCAAAAATTTGGGATTGGTTTAGCTGGCGGCTT
ACTTGGTGGCGCCCTTATTCTAGGAGGCGCTTATTCTGGGATTATTCCCACACCCAACGGCGGAAATAATGCGGCGACGA
CGACATCCACTAATCACGGCGACACAAAAGTCAGCAATGTAAGTTACAATGTGTCTAGCGATGTCACAAAAGCCGTGAAA
AAAGTTCAAAATTCTGTGGTTTCTGTCATTAATATGCAAAGTGCTAGCAACAATTCTTCGGCAGATGATCCTTTTGAGGG
ATTGTTCGGTGGGAATGAAGGTACTCAAGACTCTTCCGGCAACAATGGTAACGATTTAGAAGCAGCCAGTGAAGGTAGTG
GGGTTATTTATAAGAAAGATGGTAAAACGGCTTATGTCGTGACAAATAACCACGTCGTAGATAAAGCGCAAGGATTGGAA
GTTGTTTTATCTGATGGTACCAAAGTGAAAGGCGAATTAGTCGGAACCGATGCTTACACGGATTTAGCCGTGATTAAAAT
TTCTTCCGACAAAGTTGATCAAGTCGCTGAGTTTGGAAATTCTAGTAAAATCACAGTCGGTGAGCCTGCTATTGCAATTG
GTTCCCCTCTAGGCTCTGATTATGCTAACTCTGTCACACAAGGAATCATCTCTTCTGTGAATAGAAATATTACCAATAAA
AACGAGTCTGGTGAAACCATCAATATTAATGCTATTCAAACCGATGCTGCCATCAATCCAGGAAACTCTGGTGGTCCACT
AATCAATATTGAAGGACAAGTCATTGGAATTAACTCAGTAAAAATTGTGCAATCAACTAGTCAAGTGAGCGTTGAAGGGA
TGGGCTTTGCCATTCCAAGTAATGACGTAGTCAACATTATCAACCAATTAGAAAAAGATGGTAAAGTGACGCGGCCAGCT
CTCGGGATTACGATGTCTGATTTAACAGGTATCTCTTCACAACAACAAGAACAAATTTTAAAAATTCCAACTTCTGTAAA
AACTGGCGTAGTGGTTCGTGGTGTTGAAGCAGCGACCCCTGCTGAAAAGGCTGGATTGGAAAAATACGATGTTATCACGA
AAGTTGACGGCCAAGACGTAAGCTCTACTACAGATTTACAAAGCGCGCTTTACAAGAAAAAAGTTGGCGACAAAATGGAA
GTGACTTATTATCGTGGTTCTAAAGAAATGAAAGCAACTATCGATTTAACCATTGATAAATCAGCTTTAACACAACAAAA
TAATCGCAGCAATCAATAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(132-277)

PDZ domain (PDZ_2)

(319-416)

Peptidase family M50 (Peptidase_M50)

(9-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.171

94.907

0.505
  htrA Streptococcus mutans UA159

58.63

84.491

0.495
  htrA Streptococcus mitis NCTC 12261

55.135

85.648

0.472
  htrA Streptococcus pneumoniae TIGR4

55.807

81.713

0.456
  htrA Streptococcus pneumoniae Rx1

55.807

81.713

0.456
  htrA Streptococcus pneumoniae D39

55.807

81.713

0.456
  htrA Streptococcus pneumoniae R6

55.807

81.713

0.456