Detailed information    

insolico Bioinformatically predicted

Overview

Name   pknB   Type   Regulator
Locus tag   PY824_RS02545 Genome accession   NZ_CP119172
Coordinates   454281..456197 (+) Length   638 a.a.
NCBI ID   WP_014294070.1    Uniprot ID   -
Organism   Streptococcus macedonicus strain SGM CIP105683     
Function   modulate the activity of ComDE; modulate the activity of VicKR (predicted from homology)   
Competence regulation

Genomic Context

Location: 449281..461197
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PY824_RS02530 (PY824_02530) fmt 451259..452194 (+) 936 WP_039670518.1 methionyl-tRNA formyltransferase -
  PY824_RS02535 (PY824_02535) rsmB 452184..453506 (+) 1323 WP_014294068.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  PY824_RS02540 (PY824_02540) - 453544..454281 (+) 738 WP_014294069.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  PY824_RS02545 (PY824_02545) pknB 454281..456197 (+) 1917 WP_014294070.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  PY824_RS02550 (PY824_02550) liaF 456308..457003 (+) 696 WP_014294071.1 cell wall-active antibiotics response protein LiaF -
  PY824_RS02555 (PY824_02555) - 457000..458025 (+) 1026 WP_014294072.1 sensor histidine kinase -
  PY824_RS02560 (PY824_02560) - 458009..458653 (+) 645 WP_009853571.1 response regulator transcription factor -
  PY824_RS02565 (PY824_02565) - 458772..460172 (+) 1401 WP_115265993.1 Cof-type HAD-IIB family hydrolase -
  PY824_RS02570 (PY824_02570) - 460172..460528 (+) 357 WP_014294074.1 S1 RNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 638 a.a.        Molecular weight: 68997.08 Da        Isoelectric Point: 4.9116

>NTDB_id=798037 PY824_RS02545 WP_014294070.1 454281..456197(+) (pknB) [Streptococcus macedonicus strain SGM CIP105683]
MIQIGKLFAGRYRILKSIGRGGMADVYLAKDLILDNEEVAIKVLRTNYQTDQIAVARFQREARAMAELNHPNIVSIRDIG
EEDGQQFLVMEYVDGSDLKKYIQDHAPLSNNEVVRIMEEVLSAMTLAHQQGIVHRDLKPQNILLTKDGTVKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIMLFEMLTGHIPYDGDSAVTIALQHFQKPLPSIIDENKNVP
QALENVVIKATAKRLSDRYASTFEMSRDLMTALFYNRSREPKLVFEDTENTKTLPKVTTSTSVPSTTEQLLKKQKAAKED
KAATENKATKAKTKKKKSHRMFGTLMKIFFAVVIVAIAIFTYLTLTSPSTVSVPDVAGSSLSEAKTTIKSSGLKVGTVHE
VSSDTVESGYVIKTSPTAGSSKKEGSSIDIYVSKGLSGFKIKDYTGQDYQTAVKDLVNNYGVSESQIEIEEVSTSDYDEG
VIISQTPSEGGTFKVSGDDKITFKVATESTVTMPNLTGYTYSEAIAALTALGVSSSHITAYQANPNSSTGYVQVSSPSST
ATVTAQTPYYGDTLSDNVVLYLAADEEESSQAPSSSSSESSESKESSSSSSESSESKESSSSSSSTDDSSSSTETSDE

Nucleotide


Download         Length: 1917 bp        

>NTDB_id=798037 PY824_RS02545 WP_014294070.1 454281..456197(+) (pknB) [Streptococcus macedonicus strain SGM CIP105683]
ATGATTCAGATTGGCAAATTATTTGCTGGTCGTTATCGGATCCTCAAATCTATCGGACGGGGTGGAATGGCAGATGTTTA
TCTGGCAAAAGATCTCATTCTTGATAATGAAGAAGTTGCCATTAAGGTGCTTCGGACGAATTATCAGACTGATCAAATTG
CCGTAGCGCGTTTCCAACGGGAAGCGCGTGCCATGGCAGAACTGAACCATCCAAATATTGTCTCGATTCGTGATATTGGA
GAAGAAGATGGACAGCAATTCTTAGTAATGGAATATGTTGATGGCTCGGACTTAAAAAAATACATTCAAGATCATGCTCC
GCTTTCTAATAATGAAGTTGTTAGAATCATGGAAGAAGTCCTATCTGCGATGACTTTGGCGCATCAACAAGGAATTGTTC
ACCGTGATTTAAAACCACAAAATATATTATTAACCAAAGACGGAACTGTTAAAGTTACTGATTTTGGTATCGCCGTAGCC
TTTGCCGAAACAAGTTTAACGCAAACCAATTCAATGCTAGGTAGTGTGCATTATTTATCGCCTGAACAAGCACGTGGTTC
AAAAGCGACTGTTCAAAGTGATATTTACGCTATGGGGATTATGTTGTTTGAAATGTTAACAGGTCACATCCCATATGATG
GCGATTCAGCTGTTACCATTGCGCTTCAACATTTCCAAAAACCACTTCCTTCCATCATTGATGAGAATAAAAATGTGCCA
CAAGCACTAGAAAATGTTGTTATCAAGGCGACTGCAAAACGTTTAAGTGACCGTTATGCGTCAACTTTTGAAATGAGTCG
TGATTTGATGACGGCACTTTTTTACAACCGTAGCCGTGAACCTAAACTTGTTTTTGAAGATACTGAAAATACAAAGACAC
TTCCAAAGGTAACAACATCAACATCTGTTCCTTCAACGACAGAACAACTTTTGAAGAAACAAAAAGCAGCTAAAGAAGAT
AAAGCAGCAACAGAAAACAAAGCGACTAAAGCTAAAACAAAGAAGAAAAAATCACATCGTATGTTCGGCACGTTAATGAA
AATCTTTTTTGCAGTTGTGATTGTAGCTATTGCTATCTTTACATACTTGACGTTGACCTCACCATCAACCGTGAGTGTTC
CAGATGTTGCTGGCTCTAGTTTATCAGAAGCAAAAACAACGATAAAATCATCAGGTCTTAAAGTTGGAACCGTCCATGAA
GTATCAAGCGATACCGTCGAGAGTGGTTACGTTATTAAGACAAGTCCAACTGCTGGTTCATCGAAAAAAGAAGGGTCATC
AATTGATATTTACGTATCAAAAGGCTTATCAGGATTCAAGATAAAAGACTATACAGGTCAAGATTATCAAACAGCCGTTA
AAGATTTGGTTAATAATTATGGTGTTTCAGAGTCGCAAATTGAGATTGAAGAAGTCTCAACGTCAGATTATGACGAAGGT
GTTATCATCAGTCAAACACCTAGCGAAGGTGGAACCTTTAAGGTAAGTGGTGATGATAAGATTACCTTTAAAGTAGCTAC
TGAGAGTACAGTAACAATGCCGAATTTGACAGGATATACTTATTCAGAAGCTATTGCTGCCCTGACGGCTCTAGGTGTAT
CAAGTTCACATATTACGGCTTATCAAGCCAATCCCAATTCATCTACGGGTTATGTGCAAGTAAGCTCACCATCTTCAACA
GCAACTGTCACTGCTCAGACACCATATTATGGTGATACACTAAGTGATAACGTGGTACTTTACCTAGCAGCTGATGAAGA
AGAAAGCTCACAGGCACCATCGTCATCAAGCTCAGAATCCTCTGAATCAAAAGAATCAAGTTCATCAAGCTCAGAATCCT
CTGAATCAAAAGAATCAAGTTCATCAAGCAGTAGTACAGATGACAGTAGCTCATCGACAGAAACAAGTGATGAATAA

Domains

Predicted by InterproScan.

PASTA domain (PASTA)

(511-580)

PASTA domain (PASTA)

(440-506)

PASTA domain (PASTA)

(371-434)

Protein kinase domain (Pkinase)

(12-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pknB Streptococcus mutans UA159

68.484

92.006

0.63
  stkP/pknB Streptococcus salivarius strain HSISS4

62.421

99.687

0.622
  stkP Streptococcus pneumoniae TIGR4

58.161

83.542

0.486
  stkP Streptococcus pneumoniae D39

57.974

83.542

0.484
  stkP Streptococcus pneumoniae R6

57.974

83.542

0.484
  stkP Streptococcus pneumoniae Rx1

57.786

83.542

0.483