Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   PYW37_RS12050 Genome accession   NZ_CP118969
Coordinates   2357389..2358615 (+) Length   408 a.a.
NCBI ID   WP_023189026.1    Uniprot ID   Q66RU0
Organism   Lactococcus lactis strain DSM 20481     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2352389..2363615
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PYW37_RS12025 - 2353480..2354283 (-) 804 WP_023189023.1 phosphatidate cytidylyltransferase -
  PYW37_RS12030 - 2354283..2355017 (-) 735 WP_003130589.1 isoprenyl transferase -
  PYW37_RS12035 yajC 2355390..2355722 (-) 333 WP_003130588.1 preprotein translocase subunit YajC -
  PYW37_RS12040 - 2355817..2356515 (-) 699 WP_023189024.1 DNA alkylation repair protein -
  PYW37_RS12045 rlmH 2356534..2357013 (-) 480 WP_025017135.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  PYW37_RS12050 htrA 2357389..2358615 (+) 1227 WP_023189026.1 S1C family serine protease Regulator
  PYW37_RS12055 - 2358741..2359739 (+) 999 WP_023189027.1 glycosyltransferase family 4 protein -
  PYW37_RS12060 - 2359865..2361205 (+) 1341 WP_023189028.1 glycosyltransferase family 4 protein -
  PYW37_RS12065 - 2361313..2361537 (+) 225 WP_003130579.1 YkuJ family protein -
  PYW37_RS12070 - 2361679..2362683 (+) 1005 WP_023189029.1 hypothetical protein -
  PYW37_RS12075 - 2362724..2363476 (-) 753 WP_025017134.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -

Sequence

Protein


Download         Length: 408 a.a.        Molecular weight: 41671.95 Da        Isoelectric Point: 4.9794

>NTDB_id=796981 PYW37_RS12050 WP_023189026.1 2357389..2358615(+) (htrA) [Lactococcus lactis strain DSM 20481]
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQSANNSRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKDNS
QSSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLFSGGQKVKASVVGYDEYTDLAV
LKISSEHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSG
GALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGIRMVDLSQLSTNDSSQLKLPS
SVTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLE
TSSSSSSN

Nucleotide


Download         Length: 1227 bp        

>NTDB_id=796981 PYW37_RS12050 WP_023189026.1 2357389..2358615(+) (htrA) [Lactococcus lactis strain DSM 20481]
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACAGGTGTCGTGGGCGGAGCCATCGCACTTGGAGGAAGTGCAATCTA
TCAAAGCACTACAAATCAATCGGCAAATAATAGTCGTTCAAATACAACTAGTACAAAGGTTAGTAACGTTTCGGTAAATG
TCAATACCGATGTTACCTCTGCAATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAAGATAACTCA
CAAAGTAGTGACTTCAGTTCAATTTTTGGTGGAAATAGCGGTTCAAGTTCATCGACTGATGGCTTACAGCTTTCTAGTGA
AGGCTCTGGTGTCATCTACAAAAAATCTGGTGGAGATGCCTACGTTGTAACTAACTACCACGTTATTGCTGGTAATAGCT
CACTTGATGTTCTGTTTTCTGGTGGACAAAAAGTCAAAGCTTCTGTGGTTGGTTATGATGAATACACAGACCTTGCTGTT
CTTAAAATCAGTTCTGAACATGTCAAAGATGTGGCGACATTCGCTGATTCTAGTAAATTAACAATTGGTGAACCTGCCAT
TGCCGTTGGCTCACCTTTAGGTAGTCAATTTGCTAACACCGCAACTGAGGGAATTTTATCTGCAACAAGCCGTCAAGTGA
CTTTGACCCAAGAAAATGGTCAAACAACTAATATCAATGCAATTCAAACAGATGCTGCCATTAACCCTGGTAACTCTGGA
GGGGCTTTGATTAATATTGAAGGACAAGTTATTGGAATTACTCAAAGTAAAATTACAACAACTGAAGATGGTTCTACTTC
TGTCGAAGGTTTAGGATTTGCGATTCCTTCTAATGATGTCGTAAATATCATTAATAAACTTGAAGCTGATGGTAAGATTT
CACGCCCTGCTTTAGGTATCCGAATGGTTGACCTTTCACAATTATCAACAAATGACAGTTCTCAATTGAAATTACCAAGC
AGTGTAACAGGTGGAGTTGTTGTTTACTCCGTCCAATCTGGACTTCCTGCTGCCTCAGCTGGTTTGAAAGCTGGAGATGT
AATTACAAAGGTTGGCGATACAGCAGTAACTTCTTCAACAGACTTGCAAAGTGCTCTTTACTCACACAATATCAATGATA
CAGTAAAAGTTACTTATTATCGTGATGGTAAATCAAATACAGCAGATGTTAAACTTTCTAAATCAACCAGTGACTTAGAA
ACAAGCAGTTCATCTTCTTCTAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(254-396)

PDZ domain (PDZ_2)

(296-392)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q66RU0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

56.021

93.627

0.525
  htrA Streptococcus gordonii str. Challis substr. CH1

54.22

95.833

0.52
  htrA Streptococcus pneumoniae D39

58.017

84.069

0.488
  htrA Streptococcus pneumoniae TIGR4

58.017

84.069

0.488
  htrA Streptococcus pneumoniae R6

58.017

84.069

0.488
  htrA Streptococcus pneumoniae Rx1

58.017

84.069

0.488
  htrA Streptococcus mutans UA159

52.989

90.196

0.478