Detailed information NTG0796936

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: PYW37_RS00460
• Genome accession: NZ_CP118969
• Coordinates: 79627..81132 (+)
• Length: 501 a.a.
• NCBI ID: WP_269670455.1
• Uniprot ID: A0A0B8QXL5
• Organism: Lactococcus lactis strain DSM 20481
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 74627..86132

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PYW37_RS00435	-	75766..76233 (+)	468	WP_010905090.1	universal stress protein	-
PYW37_RS00440	-	76361..76558 (+)	198	WP_012896939.1	DUF4649 domain-containing protein	-
PYW37_RS00445	-	76589..77210 (+)	622	Protein_78	alpha/beta hydrolase	-
PYW37_RS00450	-	77261..78430 (+)	1170	WP_010905093.1	ring-cleaving dioxygenase	-
PYW37_RS00455	-	78441..79031 (+)	591	WP_023189481.1	flavin reductase family protein	-
PYW37_RS00460	comA	79627..81132 (+)	1506	WP_269670455.1	peptide cleavage/export ABC transporter	Regulator
PYW37_RS00465	-	81159..81647 (+)	489	WP_230494238.1	hypothetical protein	-
PYW37_RS00470	-	81942..82442 (+)	501	WP_223848591.1	HlyD family efflux transporter periplasmic adaptor subunit	-
PYW37_RS00475	-	82537..82662 (+)	126	WP_021214955.1	lactococcin family bacteriocin	-
PYW37_RS00480	-	82988..83356 (+)	369	WP_223848592.1	transporter	-
PYW37_RS00485	-	83395..84051 (+)	657	WP_021214956.1	type II CAAX endopeptidase family protein	-
PYW37_RS00490	-	84154..84435 (-)	282	WP_010905098.1	hypothetical protein	-
PYW37_RS00495	-	84445..84597 (-)	153	WP_010905099.1	hypothetical protein	-

Sequence

Protein

• Length: 501 a.a.
• Molecular weight: 56302.21 Da
• Isoelectric Point: 8.9296

>NTDB_id=796936 PYW37_RS00460 WP_269670455.1 79627..81132(+) (comA) [Lactococcus lactis strain DSM 20481]
MKFKKKNYTSQVDEMDCGCAALSMILKSYGTEKSLASLRLLAGTTIEGTSALGIKKAGEGLGFVVQVLRADASLFEMKKV
PYPFIAHVIKNQKYPHYYVITGANKNSVFIADPDPTVKMTKLSKEVFLSEWTGISLFLSPTPSYQPTKEKTSSLLSFIPI
ITRQKKVILNIVIASFIVTLINILGSYYLQSMIDSYIPNALMGTLGIISVGLLLTYIIQQVLEFAKAFLLNVLSQRLAID
VILSYIRHIFQLPMSFFSTRRTGEITSRFSDASSILDAIASTILSLFLDLTIVLMTGLILGLQNMQLFLLVLLAIPLYIV
VIIIFTPLFERQNHEVMQTNAILNSSIIEDINGIETIKALASEQERYQKIDYEFASYLKEAFTLQQSEAIQTAIKTTVQL
VLNVLILWFGATLVMHQKITLGQFITFNALLSYFTNPITNIINLQTKLQKARVANERLNEVYLVPSEFEEKKTELSLSHF
NLNMSEISYQFFHFLSFLLGG

Nucleotide

• Length: 1506 bp

>NTDB_id=796936 PYW37_RS00460 WP_269670455.1 79627..81132(+) (comA) [Lactococcus lactis strain DSM 20481]
ATGAAATTTAAAAAGAAAAATTATACCTCCCAAGTAGATGAAATGGATTGTGGATGTGCTGCTTTATCAATGATTTTAAA
ATCCTATGGGACAGAAAAATCGCTTGCCTCTCTTCGTTTACTTGCTGGTACAACAATCGAGGGAACTTCCGCTTTAGGAA
TAAAAAAAGCAGGAGAAGGTTTAGGTTTTGTAGTTCAAGTACTAAGAGCTGATGCAAGCCTTTTTGAAATGAAGAAAGTC
CCTTACCCTTTTATTGCTCATGTCATCAAGAACCAAAAGTATCCACACTACTATGTGATAACTGGCGCAAATAAAAATTC
GGTATTCATCGCAGATCCTGACCCAACCGTTAAAATGACAAAACTTTCAAAAGAAGTTTTCTTATCAGAGTGGACAGGCA
TTAGCTTATTTCTTTCACCTACCCCATCCTATCAGCCCACTAAAGAAAAAACTTCTTCATTATTATCTTTTATCCCAATT
ATCACCCGTCAAAAGAAAGTCATTCTCAATATTGTAATTGCCTCATTCATTGTAACGTTGATTAATATTCTAGGGTCTTA
CTACCTCCAGAGCATGATTGATAGTTACATTCCAAATGCCTTAATGGGAACTTTAGGGATTATCTCAGTAGGGCTATTGT
TAACTTATATTATCCAACAAGTCTTAGAGTTTGCTAAGGCTTTCTTACTAAACGTTCTTTCTCAAAGATTAGCCATTGAT
GTCATCCTTTCCTATATTAGACACATTTTCCAACTCCCGATGTCTTTCTTTTCGACTAGAAGAACAGGGGAAATTACCAG
TCGGTTTTCCGATGCCAGTTCTATTTTGGATGCTATTGCCTCAACGATTCTTTCGCTCTTTTTAGATTTAACCATTGTTC
TTATGACAGGACTGATTTTAGGGCTTCAAAATATGCAACTCTTTCTTCTCGTTCTTTTGGCAATCCCACTTTATATTGTT
GTTATTATTATTTTTACTCCGCTTTTTGAAAGACAAAATCATGAAGTTATGCAAACCAATGCCATCTTAAATTCCTCAAT
TATTGAAGACATTAATGGGATTGAAACCATCAAAGCGCTCGCCAGTGAACAAGAGAGATATCAAAAAATTGACTACGAAT
TTGCAAGTTATCTAAAAGAGGCTTTCACTTTACAACAGTCAGAAGCCATTCAGACGGCAATAAAAACGACAGTACAACTT
GTACTAAATGTTCTTATTTTATGGTTTGGTGCAACTTTAGTCATGCATCAAAAAATTACCCTCGGACAATTCATTACTTT
TAATGCCTTGCTTTCTTACTTTACAAATCCAATTACTAATATCATTAACCTTCAAACAAAACTACAAAAGGCAAGGGTAG
CCAATGAACGATTAAATGAGGTCTATCTTGTACCCAGTGAATTTGAAGAAAAGAAAACAGAACTGTCCCTCTCACATTTT
AATTTAAACATGTCTGAGATTTCATATCAATTCTTCCACTTTTTATCCTTCTTGTTGGGGGGGTAA

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (169-437)

• Peptidase C39 family (Peptidase_C39) (6-142)

3D structure

• AlphaFold DB: A0A0B8QXL5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus gordonii str. Challis substr. CH1	60.243	98.403	0.593
comA	Streptococcus mitis NCTC 12261	57.685	100	0.577
comA	Streptococcus pneumoniae Rx1	57.809	98.403	0.569
comA	Streptococcus pneumoniae D39	57.809	98.403	0.569
comA	Streptococcus pneumoniae R6	57.809	98.403	0.569
comA	Streptococcus mitis SK321	57.809	98.403	0.569
comA	Streptococcus pneumoniae TIGR4	57.809	98.403	0.569
comA/nlmT	Streptococcus mutans UA159	56.478	98.603	0.557