Detailed information    

insolico Bioinformatically predicted

Overview

Name   pilC   Type   Machinery gene
Locus tag   HIY_RS04135 Genome accession   NZ_AP022867
Coordinates   788569..789789 (+) Length   406 a.a.
NCBI ID   WP_005656262.1    Uniprot ID   A0A0H3PN39
Organism   Haemophilus influenzae strain 2018-Y40     
Function   type IV pilus biogenesis and function (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 783569..794789
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HIY_RS04115 (HIY_07940) corC 784537..785436 (-) 900 WP_005656283.1 CNNM family magnesium/cobalt transport protein CorC -
  HIY_RS04120 (HIY_07950) ampD 786057..786617 (-) 561 WP_005648974.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -
  HIY_RS04125 (HIY_07960) pilA 786732..787181 (+) 450 WP_005656280.1 prepilin-type N-terminal cleavage/methylation domain-containing protein Machinery gene
  HIY_RS04130 (HIY_07970) pilB 787178..788572 (+) 1395 WP_005656265.1 GspE/PulE family protein Machinery gene
  HIY_RS04135 (HIY_07980) pilC 788569..789789 (+) 1221 WP_005656262.1 type II secretion system F family protein Machinery gene
  HIY_RS04140 (HIY_07990) pilD 789786..790478 (+) 693 WP_005656260.1 A24 family peptidase Machinery gene
  HIY_RS04145 (HIY_08000) rho 790532..791794 (-) 1263 WP_005648966.1 transcription termination factor Rho -
  HIY_RS04150 (HIY_08010) metJ 792042..792359 (+) 318 WP_005631186.1 met regulon transcriptional regulator MetJ -
  HIY_RS04155 (HIY_08020) cueR 792373..792759 (-) 387 WP_005648963.1 Cu(I)-responsive transcriptional regulator -
  HIY_RS04160 (HIY_08030) - 792836..793042 (+) 207 WP_005689491.1 heavy-metal-associated domain-containing protein -
  HIY_RS04165 (HIY_08040) - 793116..793322 (+) 207 WP_005660027.1 heavy-metal-associated domain-containing protein -
  HIY_RS04170 (HIY_08050) - 793396..793602 (+) 207 WP_005656257.1 heavy-metal-associated domain-containing protein -
  HIY_RS04175 (HIY_08060) - 793676..793882 (+) 207 WP_005656255.1 heavy-metal-associated domain-containing protein -
  HIY_RS04180 (HIY_08070) - 793956..794162 (+) 207 WP_005656254.1 heavy-metal-associated domain-containing protein -

Sequence

Protein


Download         Length: 406 a.a.        Molecular weight: 46225.50 Da        Isoelectric Point: 9.8177

>NTDB_id=79568 HIY_RS04135 WP_005656262.1 788569..789789(+) (pilC) [Haemophilus influenzae strain 2018-Y40]
MTKKLFYYQGSNALNQKQKGSIIADTKQQAHFQLISCGLTHIKLQQNWQFGTKPKNSEISELLNQLATLLQSAIPLKNSL
QILQQNCTHIMLNEWLERLLQSIEAGLAFSQAIEQQGKYLTQQEIQLIQVGEMTGKLAVVCKKIATHRSQSLALQRKLQK
IMLYPSMVLGISLLLTLALLLFIVPQFAEMYSGNNAELPTITAILLSISNFLKQNIGILLFFVLSFFLFYYFYLKRQTWF
HQKKNQLISITPIFGTIQKLSRLVNFSQSLQIMLQAGVPLNQALDSFLPRTQTWQTKKTLVNDMVLDKEVRSILQWVSQG
YAFSNSVSSDLFPMEAQQMLQIGEQSGKLALMLEHIAENYQEKLNHQINLLSQMLEPLIMVIIGSLIGIIMMGMYLPIFN
MGSVIQ

Nucleotide


Download         Length: 1221 bp        

>NTDB_id=79568 HIY_RS04135 WP_005656262.1 788569..789789(+) (pilC) [Haemophilus influenzae strain 2018-Y40]
ATGACTAAAAAACTCTTTTATTATCAAGGTAGTAACGCATTAAATCAGAAACAAAAAGGCTCAATTATTGCGGATACGAA
ACAACAAGCACACTTTCAATTAATAAGCTGCGGGCTTACTCACATCAAATTACAACAAAACTGGCAATTTGGGACAAAGC
CCAAAAATTCAGAAATCAGTGAATTACTCAATCAATTAGCCACGTTGCTACAGTCCGCTATTCCGTTAAAAAACAGCCTG
CAAATTTTGCAACAAAATTGTACTCACATTATGCTCAATGAATGGCTTGAACGACTACTTCAATCTATTGAAGCTGGTTT
AGCATTTTCACAAGCCATTGAACAACAAGGGAAATATCTCACTCAACAAGAAATTCAACTAATTCAAGTAGGAGAAATGA
CAGGCAAACTAGCCGTAGTTTGTAAAAAAATAGCCACACATCGCAGCCAATCTTTAGCATTACAACGTAAATTACAGAAA
ATCATGCTGTACCCATCAATGGTGTTAGGAATTTCACTATTACTAACACTCGCATTACTGCTTTTTATCGTGCCTCAATT
TGCTGAAATGTACAGTGGCAATAATGCGGAGTTACCAACAATAACCGCAATATTGCTCTCAATATCCAATTTTCTTAAGC
AAAATATTGGCATTTTGCTATTTTTCGTTTTGAGTTTTTTTCTATTTTATTATTTCTATTTAAAACGCCAGACTTGGTTT
CATCAAAAGAAAAATCAACTTATTTCTATCACGCCTATTTTTGGCACAATTCAAAAGCTTTCACGTTTAGTGAACTTTAG
TCAAAGTTTACAAATTATGTTGCAGGCCGGCGTACCGCTTAATCAGGCACTAGACAGTTTTCTTCCTCGCACACAAACTT
GGCAAACCAAGAAAACGCTTGTAAACGATATGGTATTAGATAAAGAAGTGCGGTCAATTTTGCAATGGGTTTCTCAAGGC
TATGCGTTTTCTAATAGCGTAAGTAGCGATCTTTTCCCGATGGAAGCACAACAAATGCTACAAATTGGCGAGCAAAGCGG
AAAACTTGCTTTGATGCTAGAACATATTGCGGAAAATTACCAAGAAAAACTTAATCATCAAATTAACTTACTCTCACAAA
TGCTAGAACCATTAATAATGGTGATCATCGGCAGTCTGATTGGAATTATTATGATGGGAATGTATTTACCTATCTTTAAT
ATGGGATCAGTTATTCAATGA

Domains

Predicted by InterproScan.

Type II secretion system (T2SS), protein F (T2SSF)

(63-185)

Type II secretion system (T2SS), protein F (T2SSF)

(266-397)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H3PN39

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  pilC Haemophilus influenzae 86-028NP

97.537

100

0.975
  pilC Haemophilus influenzae Rd KW20

97.291

100

0.973
  pilC Glaesserella parasuis strain SC1401

38.404

98.768

0.379

Multiple sequence alignment