Detailed information NTG0794727

Bioinformatically predicted

Overview

• Name: stkP
• Type: Regulator
• Locus tag: PW252_RS02120
• Genome accession: NZ_CP118735
• Coordinates: 426271..428289 (+)
• Length: 672 a.a.
• NCBI ID: WP_248050120.1
• Uniprot ID: A0AA96VLR5
• Organism: Streptococcus iners strain 29887
• Function: require for competence development; phosphorylate ComE (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
ICE	417955..436429	426271..428289	within	0

Gene organization within MGE regions

Location: 417955..436429

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PW252_RS02085 (PW252_02085)	-	417955..419568 (+)	1614	WP_248050124.1	ribonuclease Y	-
PW252_RS02090 (PW252_02090)	gmk	419688..420308 (+)	621	WP_043025413.1	guanylate kinase	-
PW252_RS02095 (PW252_02095)	rpoZ	420341..420655 (+)	315	WP_004195201.1	DNA-directed RNA polymerase subunit omega	-
PW252_RS02100 (PW252_02100)	-	420725..423115 (+)	2391	WP_248050123.1	primosomal protein N'	-
PW252_RS02105 (PW252_02105)	fmt	423257..424192 (+)	936	WP_248050218.1	methionyl-tRNA formyltransferase	-
PW252_RS02110 (PW252_02110)	rsmB	424182..425495 (+)	1314	WP_248050122.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
PW252_RS02115 (PW252_02115)	-	425534..426271 (+)	738	WP_105117725.1	Stp1/IreP family PP2C-type Ser/Thr phosphatase	-
PW252_RS02120 (PW252_02120)	stkP	426271..428289 (+)	2019	WP_248050120.1	Stk1 family PASTA domain-containing Ser/Thr kinase	Regulator
PW252_RS02125 (PW252_02125)	liaF	428523..429218 (+)	696	WP_248050118.1	cell wall-active antibiotics response protein LiaF	-
PW252_RS02130 (PW252_02130)	-	429215..430231 (+)	1017	WP_172082768.1	sensor histidine kinase	-
PW252_RS02135 (PW252_02135)	-	430203..430844 (+)	642	WP_105124382.1	response regulator transcription factor	-
PW252_RS02140 (PW252_02140)	-	430890..432290 (+)	1401	WP_248050116.1	bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase	-
PW252_RS02145 (PW252_02145)	-	432292..432663 (+)	372	WP_105117730.1	S1 RNA-binding domain-containing protein	-
PW252_RS02150 (PW252_02150)	-	432745..434001 (-)	1257	WP_316716633.1	ISL3 family transposase	-
PW252_RS02155 (PW252_02155)	cysK	434099..435043 (-)	945	WP_248051490.1	cysteine synthase A	-
PW252_RS02160 (PW252_02160)	-	435272..436429 (-)	1158	WP_248051491.1	tyrosine-type recombinase/integrase	-

Sequence

Protein

• Length: 672 a.a.
• Molecular weight: 72270.04 Da
• Isoelectric Point: 6.0724

>NTDB_id=794727 PW252_RS02120 WP_248050120.1 426271..428289(+) (stkP) [Streptococcus iners strain 29887]
MIQIGKIFAGRYRIVRQIGRGGMADVYLARDLILDGEEVAVKVLRTNYQTDQIAIQRFQREARAMADLDHPNIVRISDIG
EEDGQQYLAMEYINGLDLKRYIKENAPLSNDVAVRIMGQILLAMRMAHTRGIVHRDLKPQNVILTSSGVAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATIQSDIYAMGIILFEMLTGRIPYDGDSAVTIALQHFQKPLPSVREENANVP
QALENVVLKATAKKLSERYKSVAEMYTDLASSLSLDRRNEPKVVLEENKVDTKTLPKLSQANVDIKPVASAEAVKTKADK
QPTGKQDNSKQKAVAKPVAKARQGVRTRFKVLFGVFLLTLMAVGSIFFNSPKTVTVPNVAGQTVEKAQEMIEIAGLEVGN
VTKEATNEVAEGLVIRTSPGANSSKRQGSKVDLVIATAAMVVIPDVSGKDQETAQQELEALGLQVSVKEEYSLTVDKGVV
IKTNPEVNASAEKGSSITLYVSKGVVVPNVIGRSQESATQMLQDAGFYIGTITQVYSSSVEAGQVISTDPVADTELERGA
VINLEVSKGKELIMPDLTSGHLTYSQASSQLQTLGVKVANIEKQEDRSYYSTTSDIVIGQYPAAGNTIEGTVTLYVSVAT
ATTSSESSSTSSTASSISSSSSSSASISDSGQ

Nucleotide

• Length: 2019 bp

>NTDB_id=794727 PW252_RS02120 WP_248050120.1 426271..428289(+) (stkP) [Streptococcus iners strain 29887]
ATGATTCAAATCGGTAAGATCTTTGCTGGACGCTATCGGATTGTCCGGCAAATTGGTCGAGGCGGTATGGCGGATGTCTA
TCTGGCTAGGGATTTGATATTGGATGGGGAAGAAGTGGCTGTTAAGGTCCTCCGCACCAACTATCAGACTGACCAGATTG
CCATCCAGCGTTTCCAACGGGAAGCGCGTGCTATGGCGGACCTGGATCACCCAAATATTGTTCGTATTTCGGACATTGGT
GAGGAAGATGGTCAACAGTATCTAGCCATGGAATACATCAATGGCCTTGACTTGAAACGCTATATCAAGGAGAATGCTCC
TCTTTCAAACGATGTAGCAGTTCGTATCATGGGACAAATTCTCCTAGCTATGCGGATGGCCCATACTCGTGGTATTGTCC
ATAGGGACCTGAAACCTCAGAATGTTATCTTGACATCAAGTGGTGTCGCTAAGGTAACGGACTTTGGTATTGCAGTTGCC
TTTGCGGAAACCAGTTTGACCCAAACCAACTCCATGCTGGGCTCTGTCCACTATCTTTCACCGGAGCAGGCGCGTGGTTC
TAAAGCAACTATTCAAAGTGACATCTATGCAATGGGAATTATCTTGTTTGAGATGTTGACCGGCCGTATCCCTTATGATG
GGGATAGTGCTGTGACTATCGCACTTCAGCATTTTCAAAAACCACTGCCATCGGTTAGAGAAGAGAATGCCAATGTGCCA
CAGGCTTTGGAAAACGTAGTGTTAAAAGCAACAGCTAAAAAATTAAGCGAGCGCTATAAGTCTGTTGCAGAAATGTACAC
AGACCTAGCCTCATCCTTGTCCTTGGATCGTAGGAATGAACCCAAAGTTGTCCTAGAGGAGAACAAGGTTGATACAAAAA
CTTTGCCTAAGTTATCTCAGGCAAATGTTGATATCAAGCCAGTAGCTAGTGCAGAGGCTGTCAAAACGAAGGCTGATAAA
CAGCCGACAGGTAAGCAGGACAACTCGAAACAAAAAGCAGTTGCTAAACCAGTAGCCAAGGCTAGACAAGGGGTTCGAAC
CCGTTTCAAAGTCCTATTCGGTGTCTTTCTGTTGACCCTCATGGCAGTTGGTTCGATATTCTTCAACTCACCAAAAACGG
TTACGGTGCCGAATGTAGCAGGACAAACTGTTGAGAAGGCACAAGAGATGATTGAAATTGCTGGATTGGAAGTAGGCAAT
GTTACAAAAGAGGCAACCAATGAAGTGGCTGAAGGGTTGGTTATTCGGACTTCTCCAGGCGCTAATTCTTCCAAACGTCA
GGGAAGCAAGGTTGACCTAGTCATTGCTACTGCTGCAATGGTTGTCATTCCAGATGTCAGTGGTAAAGACCAGGAAACAG
CTCAACAAGAATTGGAAGCACTAGGATTACAGGTTTCTGTTAAAGAGGAGTATAGCCTAACGGTTGATAAAGGTGTCGTC
ATCAAGACCAATCCAGAAGTCAATGCGTCAGCTGAAAAAGGTAGTAGCATCACACTCTACGTTTCTAAAGGAGTTGTGGT
ACCAAATGTGATTGGAAGAAGCCAGGAATCAGCCACCCAAATGCTTCAAGATGCAGGTTTTTATATTGGAACCATTACGC
AAGTCTATAGTTCGTCTGTTGAGGCTGGACAAGTCATCAGTACAGATCCAGTGGCGGATACCGAACTTGAGAGAGGAGCG
GTCATCAATCTTGAAGTATCTAAAGGTAAGGAATTGATCATGCCTGATTTAACTTCTGGTCACCTCACCTATTCACAGGC
CAGCAGCCAACTGCAAACCTTGGGTGTCAAGGTTGCCAATATCGAAAAACAAGAGGATAGGAGTTACTATTCAACTACAA
GTGATATTGTTATTGGTCAATATCCAGCAGCAGGTAATACTATCGAGGGGACCGTTACTCTATATGTATCGGTAGCCACA
GCTACTACTAGCTCAGAGAGTTCCTCGACTAGCTCAACAGCAAGCAGTATATCTTCTTCTAGTTCATCCTCTGCTTCTAT
ATCAGATAGTGGGCAGTAG

Domains

Predicted by InterproScan.

• PASTA domain (PASTA) (441-503)

• PASTA domain (PASTA) (573-637)

• PASTA domain (PASTA) (374-436)

• PASTA domain (PASTA) (505-568)

• Protein kinase domain (Pkinase) (12-234)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
stkP	Streptococcus pneumoniae TIGR4	53.333	95.982	0.512
stkP	Streptococcus pneumoniae D39	53.178	95.982	0.51
stkP	Streptococcus pneumoniae R6	53.178	95.982	0.51
stkP	Streptococcus pneumoniae Rx1	53.023	95.982	0.509
pknB	Streptococcus mutans UA159	55.451	79.167	0.439
stkP/pknB	Streptococcus salivarius strain HSISS4	54.664	79.762	0.436