Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   Q7621_RS00290 Genome accession   NZ_CP131712
Coordinates   46747..48900 (+) Length   717 a.a.
NCBI ID   WP_341966606.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 2008C09-280     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 41747..53900
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Q7621_RS00255 (Q7621_00255) - 42099..43268 (+) 1170 WP_000366348.1 pyridoxal phosphate-dependent aminotransferase -
  Q7621_RS00260 (Q7621_00260) recO 43265..44035 (+) 771 WP_000616164.1 DNA repair protein RecO Machinery gene
  Q7621_RS00265 (Q7621_00265) plsX 44032..45024 (+) 993 WP_000717451.1 phosphate acyltransferase PlsX -
  Q7621_RS00270 (Q7621_00270) - 45030..45263 (+) 234 WP_000136449.1 acyl carrier protein -
  Q7621_RS00275 (Q7621_00275) - 45309..45600 (+) 292 Protein_47 IS5/IS1182 family transposase -
  Q7621_RS00280 (Q7621_00280) blpU 45802..46032 (+) 231 WP_001093075.1 bacteriocin-like peptide BlpU -
  Q7621_RS00285 (Q7621_00285) - 46035..46160 (+) 126 WP_000346297.1 PncF family bacteriocin immunity protein -
  Q7621_RS00290 (Q7621_00290) comA 46747..48900 (+) 2154 WP_341966606.1 peptide cleavage/export ABC transporter ComA Regulator
  Q7621_RS00295 (Q7621_00295) comB 48913..50262 (+) 1350 WP_000801611.1 competence pheromone export protein ComB Regulator
  Q7621_RS00300 (Q7621_00300) purC 50432..51139 (+) 708 WP_000043310.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80426.53 Da        Isoelectric Point: 6.3891

>NTDB_id=791600 Q7621_RS00290 WP_341966606.1 46747..48900(+) (comA) [Streptococcus pneumoniae strain 2008C09-280]
MKFGKRHYRPQVDQMDCGVASLAMIFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPYKEQKNGLLSFIPI
LVKQRGLIANIVLATLLVIGINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGDMTFKQVHYKYGYGRYVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=791600 Q7621_RS00290 WP_341966606.1 46747..48900(+) (comA) [Streptococcus pneumoniae strain 2008C09-280]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGATTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCCATTAAGGCGGATATGACGCTTTTTGACTTGCCGGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCCGGGGTGAAGTTGACTAAACTGCCACGTGAGCGTTTTGAGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTATAAGCCTTATAAGGAACAAAAAAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCTAATATCGTTTTGGCAACACTCTTGGTAATCGGGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACACTAGGGATTATTTCTATTGGGCTAGTCA
TCGTCTACATCCTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTCCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTC
TCGTTTTACAGATGCTAACAGTATCATCGATGCGCTGGCTTCGACCATCCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTCTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCGCTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTGCTTAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGATATGACCTTCAAGCAGGTTCATTACAAGTATGGCTATGGTCGATACGTCTTGTCGGATATCAATTTAACCGT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACTTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTACATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGATATCGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCTTTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACTAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTCGATAATCTCATGGCTTT
GGACAAGACCTTGATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGGACAGAGAAGGTAGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterProScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-650)

ABC transporter transmembrane region (ABC_membrane)

(170-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus pneumoniae D39

99.163

100

0.992
  comA Streptococcus pneumoniae R6

99.163

100

0.992
  comA Streptococcus pneumoniae Rx1

99.163

100

0.992
  comA Streptococcus pneumoniae TIGR4

98.745

100

0.987
  comA Streptococcus mitis NCTC 12261

98.047

100

0.98
  comA Streptococcus mitis SK321

97.908

100

0.979
  comA Streptococcus gordonii str. Challis substr. CH1

80.753

100

0.808
  comA/nlmT Streptococcus mutans UA159

64.296

100

0.643