Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   PUW49_RS01850 Genome accession   NZ_CP118054
Coordinates   356432..357187 (+) Length   251 a.a.
NCBI ID   WP_024052137.1    Uniprot ID   A0A412PNS2
Organism   Streptococcus anginosus strain VSI37     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 351432..362187
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PUW49_RS01835 (PUW49_01835) - 351819..353384 (-) 1566 WP_024052140.1 ABC transporter substrate-binding protein/permease -
  PUW49_RS01840 (PUW49_01840) - 353510..355399 (+) 1890 WP_024052139.1 DUF2207 domain-containing protein -
  PUW49_RS01845 (PUW49_01845) - 355466..356308 (+) 843 WP_024052138.1 undecaprenyl-diphosphate phosphatase -
  PUW49_RS01850 (PUW49_01850) mecA 356432..357187 (+) 756 WP_024052137.1 adaptor protein MecA Regulator
  PUW49_RS01855 (PUW49_01855) - 357178..358344 (+) 1167 WP_070241544.1 MraY family glycosyltransferase -
  PUW49_RS01860 (PUW49_01860) sufC 358435..359205 (+) 771 WP_003025885.1 Fe-S cluster assembly ATPase SufC -
  PUW49_RS01865 (PUW49_01865) sufD 359245..360507 (+) 1263 WP_274994843.1 Fe-S cluster assembly protein SufD -
  PUW49_RS01870 (PUW49_01870) - 360523..361755 (+) 1233 WP_070241545.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 251 a.a.        Molecular weight: 29052.79 Da        Isoelectric Point: 4.1123

>NTDB_id=789653 PUW49_RS01850 WP_024052137.1 356432..357187(+) (mecA) [Streptococcus anginosus strain VSI37]
MEMKQISDTTIKITIKLEDLEERGMEMADFLVPQEKTEEFFYAILDELEMPESFLDSGMLSFRVTPKPDRLDVFVTKSKI
DKNLNFDDLADLPDVEELSQMSPDEFLKTLEKNIFEKSKDDMEAVRSLETAEADDNTSTSDMEESEENSDELTQKYIYYI
LKFSSLKEAIVFSKTVDYAVNTSELYKMDDHYYLTILVDIEGHPKRYPAWLLASMREHAEDTDVTRAVLQEHGYLLLVNE
AVASLQKVKCL

Nucleotide


Download         Length: 756 bp        

>NTDB_id=789653 PUW49_RS01850 WP_024052137.1 356432..357187(+) (mecA) [Streptococcus anginosus strain VSI37]
ATGGAAATGAAGCAAATTAGTGATACAACGATTAAGATCACAATAAAATTAGAAGATTTAGAAGAACGTGGAATGGAGAT
GGCAGATTTTCTCGTTCCGCAAGAAAAAACAGAGGAATTTTTCTATGCGATTTTAGATGAGTTGGAAATGCCAGAGAGCT
TTTTAGATAGCGGTATGCTCAGTTTTCGTGTAACTCCTAAACCAGACCGACTGGATGTTTTTGTCACCAAGTCTAAGATT
GATAAGAATTTGAACTTCGATGATTTGGCAGATTTACCAGATGTAGAAGAGCTGTCTCAAATGTCTCCAGATGAATTTTT
AAAGACATTAGAAAAAAATATTTTTGAGAAAAGTAAAGACGATATGGAGGCTGTTCGTTCTTTGGAAACGGCGGAAGCAG
ACGATAACACAAGCACTTCTGATATGGAAGAGTCAGAGGAAAATAGTGATGAGCTTACGCAAAAATATATCTATTACATT
TTGAAATTTTCCAGCCTGAAAGAAGCAATTGTTTTTTCTAAGACAGTAGATTATGCTGTCAATACTTCGGAGTTGTACAA
AATGGACGATCACTATTATTTGACAATTCTGGTTGATATTGAGGGACACCCGAAGCGTTATCCAGCTTGGCTCCTTGCCT
CTATGCGTGAACATGCAGAAGACACAGATGTGACGAGAGCTGTTTTGCAAGAACACGGTTACTTATTGCTTGTCAACGAG
GCGGTTGCCAGTCTTCAAAAGGTTAAATGCTTATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-245)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A412PNS2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

66.532

98.805

0.657
  mecA Streptococcus pneumoniae D39

66.532

98.805

0.657
  mecA Streptococcus pneumoniae R6

66.532

98.805

0.657
  mecA Streptococcus pneumoniae TIGR4

66.129

98.805

0.653
  mecA Streptococcus mutans UA159

50.201

99.203

0.498
  mecA Streptococcus thermophilus LMD-9

46.667

100

0.474
  mecA Streptococcus thermophilus LMG 18311

46.275

100

0.47