Detailed information NTG0779472

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: POF58_RS03955
• Genome accession: NZ_CP116711
• Coordinates: 714580..715290 (+)
• Length: 236 a.a.
• NCBI ID: WP_000722052.1
• Uniprot ID: X5K3L1
• Organism: Streptococcus agalactiae strain CNCTC 10/84 Cas9 AEKOrevertant
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 709580..720290

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
POF58_RS03930 (POF58_03930)	-	710688..711254 (+)	567	WP_000592392.1	PepSY domain-containing protein	-
POF58_RS03935 (POF58_03935)	-	711303..711953 (-)	651	WP_000100034.1	amino acid ABC transporter permease	-
POF58_RS03940 (POF58_03940)	-	711965..712660 (-)	696	WP_000173638.1	amino acid ABC transporter permease	-
POF58_RS03945 (POF58_03945)	-	712673..713473 (-)	801	WP_000946173.1	transporter substrate-binding domain-containing protein	-
POF58_RS03950 (POF58_03950)	-	713485..714240 (-)	756	WP_000053147.1	amino acid ABC transporter ATP-binding protein	-
POF58_RS03955 (POF58_03955)	vicR	714580..715290 (+)	711	WP_000722052.1	response regulator YycF	Regulator
POF58_RS03960 (POF58_03960)	vicK	715283..716632 (+)	1350	WP_001065469.1	cell wall metabolism sensor histidine kinase VicK	Regulator
POF58_RS03965 (POF58_03965)	vicX	716636..717445 (+)	810	WP_001289498.1	MBL fold metallo-hydrolase	Regulator
POF58_RS03970 (POF58_03970)	-	717448..717816 (+)	369	WP_000719384.1	YbaN family protein	-
POF58_RS03975 (POF58_03975)	rnc	717992..718678 (+)	687	WP_000661526.1	ribonuclease III	-

Sequence

Protein

• Length: 236 a.a.
• Molecular weight: 27063.90 Da
• Isoelectric Point: 4.8246

>NTDB_id=779472 POF58_RS03955 WP_000722052.1 714580..715290(+) (vicR) [Streptococcus agalactiae strain CNCTC 10/84 Cas9 AEKOrevertant]
MKKILIVDDEKPISDIIKFNLTKEGYETATAFDGREALVQYAEFQPDLIILDLMLPELDGLEVAKEVRKTSHIPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTENIETAVAEESAQNASSDITIGELQILPDAFIAKKRGEEIE
LTHREFELLHHLATHIGQVMTREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPGRPEYILTRRGVGYYMKSYE

Nucleotide

• Length: 711 bp

>NTDB_id=779472 POF58_RS03955 WP_000722052.1 714580..715290(+) (vicR) [Streptococcus agalactiae strain CNCTC 10/84 Cas9 AEKOrevertant]
ATGAAAAAAATACTTATCGTTGATGATGAAAAACCAATTTCAGATATTATCAAATTTAATTTAACCAAAGAAGGATATGA
GACGGCGACAGCTTTCGATGGCCGTGAAGCTTTAGTACAATATGCAGAATTTCAACCAGATTTAATCATTTTGGATTTAA
TGCTCCCTGAACTAGATGGTTTAGAAGTGGCTAAAGAAGTTCGTAAAACCAGCCATATTCCTATTATTATGCTTTCCGCA
AAAGACAGTGAGTTTGACAAAGTCATTGGTTTAGAAATCGGTGCAGATGATTATGTTACTAAACCTTTTTCAAATCGTGA
ACTTTTGGCACGGGTCAAAGCACATTTACGACGTACTGAAAATATTGAAACAGCTGTAGCAGAAGAAAGTGCTCAAAATG
CTTCTTCAGATATTACTATTGGTGAGTTGCAAATTTTACCAGACGCCTTTATTGCTAAGAAACGTGGCGAAGAAATTGAA
TTAACGCACCGAGAATTTGAATTACTTCACCATTTAGCGACACATATAGGACAAGTCATGACACGCGAACATTTATTGGA
AACGGTTTGGGGATATGATTATTTTGGAGATGTCCGTACAGTTGATGTGACGGTGAGACGTTTACGTGAAAAGATTGAAG
ATACTCCTGGTCGTCCAGAATATATTTTGACTCGACGTGGTGTAGGTTATTACATGAAGTCTTATGAATAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (156-231)

• Response regulator receiver domain (Response_reg) (4-113)

3D structure

• AlphaFold DB: X5K3L1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	88.983	100	0.89
micA	Streptococcus pneumoniae Cp1015	77.778	99.153	0.771
covR	Lactococcus lactis subsp. lactis strain DGCC12653	46.983	98.305	0.462
covR	Streptococcus salivarius strain HSISS4	44.635	98.729	0.441
scnR	Streptococcus mutans UA159	38.559	100	0.386