Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   PHA78_RS01250 Genome accession   NZ_CP116604
Coordinates   247836..248576 (+) Length   246 a.a.
NCBI ID   WP_024376264.1    Uniprot ID   A0A2I5KS06
Organism   Streptococcus sp. HN38     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 242836..253576
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PHA78_RS01225 - 244606..245937 (+) 1332 Protein_208 IS1182 family transposase -
  PHA78_RS01230 - 246067..246465 (-) 399 WP_029180393.1 hypothetical protein -
  PHA78_RS01235 - 246691..246918 (+) 228 WP_024376261.1 hypothetical protein -
  PHA78_RS01240 - 246899..247204 (+) 306 WP_044672279.1 hypothetical protein -
  PHA78_RS01245 - 247495..247836 (+) 342 WP_024378069.1 LytTR family DNA-binding domain-containing protein -
  PHA78_RS01250 comE/blpR 247836..248576 (+) 741 WP_024376264.1 response regulator transcription factor Regulator
  PHA78_RS01255 - 248586..249917 (+) 1332 WP_099780237.1 GHKL domain-containing protein -
  PHA78_RS01260 - 250115..250264 (-) 150 WP_079267743.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  PHA78_RS01265 - 250362..251723 (-) 1362 WP_024378067.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 246 a.a.        Molecular weight: 28757.89 Da        Isoelectric Point: 7.0265

>NTDB_id=778752 PHA78_RS01250 WP_024376264.1 247836..248576(+) (comE/blpR) [Streptococcus sp. HN38]
MNVFVLEDDFAQQSRIESIVGSLMERHHIQTKKFEVFGKPDQLIRAVEEKGAHQLFFLDIEIRADDKKGLEVAQQIRDID
PFAIIVFVTTHSEYMPLAFRYQVSALDFIDKELAPAEFEARIETALLYANGKNSRTVAEDSFYYKSRYAQVQVPFADILY
IETSPHPHRVILHTEKDRLEFTGNLADILKQEKRLLQCHRSYLVNPNNVVKVDRQMKVLYFRNGSNCYVARNRMELVHNA
IRDLHR

Nucleotide


Download         Length: 741 bp        

>NTDB_id=778752 PHA78_RS01250 WP_024376264.1 247836..248576(+) (comE/blpR) [Streptococcus sp. HN38]
ATGAATGTATTTGTTTTAGAAGATGATTTTGCCCAACAGTCACGGATTGAGTCAATCGTTGGTAGTTTAATGGAGCGACA
CCACATTCAGACTAAGAAGTTTGAAGTTTTTGGGAAACCAGACCAGTTGATTCGGGCAGTAGAGGAAAAAGGAGCTCATC
AACTCTTTTTCTTGGACATTGAGATTCGAGCAGATGACAAGAAGGGGTTAGAGGTGGCTCAACAGATTCGTGATATTGAT
CCCTTTGCCATTATCGTTTTTGTTACCACTCACTCCGAGTATATGCCTCTGGCCTTTCGTTATCAGGTATCGGCTCTGGA
TTTTATTGATAAGGAGCTAGCCCCGGCCGAGTTTGAGGCACGGATTGAGACAGCTCTCCTTTATGCTAATGGGAAAAATA
GTCGGACGGTGGCAGAGGATTCCTTCTATTACAAGTCGCGTTATGCCCAGGTCCAAGTTCCCTTTGCGGATATTCTCTAT
ATCGAAACCTCTCCTCATCCCCATCGGGTTATTCTGCATACGGAGAAGGATCGCTTAGAGTTTACAGGGAATTTGGCAGA
TATTTTGAAACAAGAAAAAAGACTGCTCCAGTGTCATCGCTCTTACTTGGTCAATCCCAATAATGTGGTCAAGGTTGATC
GACAGATGAAAGTTCTCTACTTCCGAAATGGTAGCAACTGCTATGTCGCTCGGAATCGAATGGAGCTAGTTCATAATGCC
ATTCGAGACTTGCATAGATAG

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-240)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2I5KS06

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

52.209

100

0.528
  comE/comE1 Streptococcus equinus JB1

44.215

98.374

0.435
  comE/comE2 Streptococcus equinus JB1

37.705

99.187

0.374
  comE/comE2 Streptococcus gordonii strain NCTC7865

37.398

100

0.374
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

37.398

100

0.374