Detailed information NTG0778744

Bioinformatically predicted

Overview

• Name: comYB
• Type: Machinery gene
• Locus tag: PHA78_RS00805
• Genome accession: NZ_CP116604
• Coordinates: 138295..139332 (+)
• Length: 345 a.a.
• NCBI ID: WP_272158556.1
• Uniprot ID: -
• Organism: Streptococcus sp. HN38
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
ICE	107951..138383	138295..139332	flank	-88

Gene organization within MGE regions

Location: 107951..139332

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PHA78_RS00680	-	107951..109099 (-)	1149	WP_024377200.1	site-specific integrase	-
PHA78_RS00685	-	109151..109492 (-)	342	WP_024376319.1	DUF771 domain-containing protein	-
PHA78_RS00690	-	109550..110788 (-)	1239	WP_024376318.1	replication initiation factor domain-containing protein	-
PHA78_RS00695	-	110882..111649 (-)	768	WP_099806850.1	AAA family ATPase	-
PHA78_RS00700	-	111649..112134 (-)	486	WP_024376316.1	hypothetical protein	-
PHA78_RS00705	-	112697..113404 (+)	708	WP_024376314.1	hypothetical protein	-
PHA78_RS00710	-	113461..113796 (-)	336	WP_306508887.1	helix-turn-helix transcriptional regulator	-
PHA78_RS00715	-	113943..116426 (+)	2484	WP_272158316.1	SEC10/PgrA surface exclusion domain-containing protein	-
PHA78_RS00720	-	116730..117350 (+)	621	WP_024376311.1	hypothetical protein	-
PHA78_RS00725	-	117520..117663 (+)	144	WP_099806715.1	putative holin-like toxin	-
PHA78_RS00730	-	118369..118812 (+)	444	WP_024377807.1	zinc-dependent MarR family transcriptional regulator	-
PHA78_RS00735	-	118813..119517 (+)	705	WP_024377806.1	metal ABC transporter ATP-binding protein	-
PHA78_RS00740	-	119510..120322 (+)	813	WP_002936593.1	metal ABC transporter permease	-
PHA78_RS00745	-	120332..121846 (+)	1515	WP_099778505.1	zinc ABC transporter substrate-binding protein AdcA	-
PHA78_RS00750	-	121949..122395 (+)	447	WP_024377804.1	CopY/TcrY family copper transport repressor	-
PHA78_RS00755	-	122392..122601 (+)	210	WP_024377803.1	heavy metal-associated domain-containing protein	-
PHA78_RS00760	-	122629..123006 (-)	378	WP_272158317.1	HIT family protein	-
PHA78_RS00765	-	123060..123842 (-)	783	WP_024377801.1	TMEM175 family protein	-
PHA78_RS00770	tyrS	123846..125102 (-)	1257	WP_024415510.1	tyrosine--tRNA ligase	-
PHA78_RS00775	pbp1b	125256..127679 (+)	2424	WP_272158318.1	penicillin-binding protein PBP1B	-
PHA78_RS00780	rpoB	128344..131916 (+)	3573	WP_002936570.1	DNA-directed RNA polymerase subunit beta	-
PHA78_RS00785	rpoC	132094..135741 (+)	3648	WP_272158319.1	DNA-directed RNA polymerase subunit beta'	-
PHA78_RS00790	-	135893..136252 (+)	360	WP_024377796.1	DUF1033 family protein	-
PHA78_RS00795	-	136397..137347 (-)	951	WP_272158320.1	S66 peptidase family protein	-
PHA78_RS00800	comYA	137433..138383 (+)	951	WP_043026808.1	competence type IV pilus ATPase ComGA	Machinery gene
PHA78_RS00805	comYB	138295..139332 (+)	1038	WP_272158556.1	competence type IV pilus assembly protein ComGB	Machinery gene

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 38894.88 Da
• Isoelectric Point: 9.1395

>NTDB_id=778744 PHA78_RS00805 WP_272158556.1 138295..139332(+) (comYB) [Streptococcus sp. HN38]
MNKLIAFLQQDISVFGRQKQKKLPLARQRKVIELFNNLFASGFHLGEIVDFLKRSQLLADPYTQVLSDGLLAGKPFSSLL
ADLRFSDAVVTQVALAEVHGNTSLSLGHIQSYLENVSKVRKKLIEVATYPVILLAFLLLIMLGLKNYLLPQLEEGNAATM
LINHLPTIFLSLCGLSLVAVLAGMVWFRKTNKIKVFSCLAALPFFGKFIQIYLTAYYAREWGSLIGQGLDLPQIVGLMQS
QQSQLFREIGQDLEQSLSNGQSFHEHIKTYAFFKRELSLIAEYGQVKSKLGSELTVYAAECWEDFFSRVNRAMQLIQPLV
FLFVALMVVLIYAAMLLPIYQNMEL

Nucleotide

• Length: 1038 bp

>NTDB_id=778744 PHA78_RS00805 WP_272158556.1 138295..139332(+) (comYB) [Streptococcus sp. HN38]
ATGAACAAATTGATCGCCTTTTTGCAGCAGGACATATCAGTCTTCGGCAGGCAGAAACAGAAAAAATTACCCTTGGCTCG
CCAGCGTAAGGTCATTGAACTGTTTAACAATCTCTTTGCCAGTGGCTTTCATCTGGGAGAGATTGTTGATTTCCTCAAAC
GTAGTCAGCTTCTGGCAGATCCCTATACCCAGGTCTTGTCAGATGGGCTGTTAGCAGGCAAACCCTTTTCAAGTTTGCTG
GCGGATTTGCGTTTTTCAGATGCGGTGGTCACGCAAGTAGCTCTGGCAGAAGTTCATGGCAATACCAGTCTGAGTTTGGG
CCATATTCAGTCCTATCTGGAAAATGTCAGCAAGGTTCGTAAAAAGCTGATTGAGGTGGCGACCTATCCAGTTATACTGC
TTGCTTTTCTTCTTTTGATTATGTTGGGTTTGAAAAATTACCTTCTGCCCCAGTTGGAGGAAGGTAATGCAGCGACTATG
CTGATAAATCATCTGCCGACTATCTTCTTATCCCTCTGTGGACTTAGTTTGGTGGCGGTCTTAGCTGGTATGGTTTGGTT
TCGCAAAACCAACAAAATCAAGGTCTTTTCCTGCTTAGCTGCTCTGCCATTTTTCGGAAAATTCATCCAAATCTATCTGA
CGGCCTATTACGCCAGGGAGTGGGGGAGTTTGATTGGGCAAGGCTTGGACCTGCCGCAGATTGTGGGCTTGATGCAATCG
CAGCAATCGCAGCTCTTTCGGGAGATTGGCCAGGACCTGGAGCAGTCGCTTTCCAATGGTCAGAGCTTTCACGAACACAT
TAAGACCTACGCCTTTTTTAAGCGGGAGCTGAGTTTGATTGCCGAGTATGGTCAGGTCAAGTCCAAGTTGGGGAGCGAGT
TGACAGTCTATGCAGCTGAGTGTTGGGAGGATTTTTTCTCTCGGGTCAATAGAGCCATGCAGCTGATCCAACCGCTGGTC
TTTCTCTTTGTGGCCTTAATGGTCGTTCTCATCTACGCAGCCATGTTGCTGCCGATTTATCAAAATATGGAGTTATAA

Domains

Predicted by InterproScan.

• Type II secretion system (T2SS), protein F (T2SSF) (218-338)

• Type II secretion system (T2SS), protein F (T2SSF) (33-150)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYB	Streptococcus gordonii str. Challis substr. CH1	63.743	99.13	0.632
comGB/cglB	Streptococcus mitis NCTC 12261	60.597	97.101	0.588
comGB/cglB	Streptococcus mitis SK321	60.299	97.101	0.586
comGB/cglB	Streptococcus pneumoniae Rx1	60	97.101	0.583
comGB/cglB	Streptococcus pneumoniae D39	60	97.101	0.583
comGB/cglB	Streptococcus pneumoniae R6	60	97.101	0.583
comGB/cglB	Streptococcus pneumoniae TIGR4	60	97.101	0.583
comYB	Streptococcus mutans UA159	58.651	98.841	0.58
comYB	Streptococcus mutans UA140	58.651	98.841	0.58
comGB	Lactococcus lactis subsp. cremoris KW2	51.039	97.681	0.499