Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   PML78_RS10390 Genome accession   NZ_CP116583
Coordinates   2212545..2213804 (-) Length   419 a.a.
NCBI ID   WP_016173794.1    Uniprot ID   S1NA36
Organism   Enterococcus dispar strain K205-4b     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2207545..2218804
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PML78_RS10360 (PML78_10360) - 2207966..2209045 (+) 1080 WP_262929311.1 hypothetical protein -
  PML78_RS10365 (PML78_10365) - 2209181..2209525 (-) 345 WP_016173789.1 PepSY domain-containing protein -
  PML78_RS10370 (PML78_10370) pepA 2209737..2210816 (+) 1080 WP_016173790.1 glutamyl aminopeptidase -
  PML78_RS10375 (PML78_10375) - 2210873..2211184 (+) 312 WP_016173791.1 thioredoxin family protein -
  PML78_RS10380 (PML78_10380) - 2211208..2211675 (+) 468 WP_016173792.1 universal stress protein -
  PML78_RS10385 (PML78_10385) ytpR 2211767..2212375 (+) 609 WP_271857225.1 YtpR family tRNA-binding protein -
  PML78_RS10390 (PML78_10390) htrA 2212545..2213804 (-) 1260 WP_016173794.1 S1C family serine protease Regulator
  PML78_RS10395 (PML78_10395) rlmH 2214170..2214649 (+) 480 WP_271857229.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  PML78_RS10400 (PML78_10400) - 2214849..2215811 (+) 963 WP_016173796.1 restriction endonuclease -
  PML78_RS10405 (PML78_10405) - 2216042..2216548 (+) 507 WP_016173797.1 DUF1456 family protein -
  PML78_RS10410 (PML78_10410) - 2216836..2218167 (+) 1332 WP_271857232.1 FAD-dependent oxidoreductase -

Sequence

Protein


Download         Length: 419 a.a.        Molecular weight: 43414.26 Da        Isoelectric Point: 4.6115

>NTDB_id=778632 PML78_RS10390 WP_016173794.1 2212545..2213804(-) (htrA) [Enterococcus dispar strain K205-4b]
MQRKKSGGALSRFFIGILGGVLGAALVGGGFYLANGSNLQPSNTTEQTTTASGETKVSNVKVNADTDITSAVEKVQDAVV
SVINLQKQQASSDNPFGDLFGQGQSESESESDSESGGLQAVGEGSGVIYKKDGKTAYVVTNNHVVEGQDGLEVVLKDGEK
IKAELVGTDSYTDLAVLKISSDKVDKTATFGDSSALKVGEPAIAIGSPLGSQYANSVTSGIISSLNRQVADSQTGVNISA
IQTDAAINPGNSGGPLVNIAGQVIGINSSKIASTNSSSSDISVEGMGFAIPSNDVVSIINQLEKDGKVTRPALGITMVDL
SAVTSQQQEQILKVPSSLKNGVVITTVQNATPAEQAGLKQYDVITKIDGKEVDSTSDLQSALYKKKVGDSIEITYYRGSK
EHTTKVSLTIDQSALKQNN

Nucleotide


Download         Length: 1260 bp        

>NTDB_id=778632 PML78_RS10390 WP_016173794.1 2212545..2213804(-) (htrA) [Enterococcus dispar strain K205-4b]
ATGCAAAGAAAAAAATCAGGAGGCGCTCTTAGTCGCTTTTTCATCGGCATACTAGGTGGTGTATTAGGAGCTGCTTTAGT
AGGTGGTGGGTTTTATCTAGCCAATGGATCAAATTTACAACCAAGTAACACAACCGAACAAACGACAACAGCCAGTGGAG
AAACAAAGGTGTCTAACGTCAAAGTTAATGCAGATACCGATATTACTTCTGCAGTCGAAAAAGTACAAGACGCTGTCGTG
TCCGTGATTAATTTACAAAAACAACAAGCTTCTTCAGATAATCCTTTTGGTGACTTATTTGGTCAAGGACAATCCGAGTC
TGAATCAGAAAGTGATAGTGAGTCAGGTGGTTTACAAGCTGTTGGTGAAGGTAGTGGTGTCATTTACAAAAAAGATGGCA
AAACAGCCTATGTAGTTACCAATAATCACGTTGTTGAAGGACAAGATGGCTTAGAAGTGGTTTTAAAAGATGGTGAAAAA
ATTAAAGCTGAATTAGTTGGAACAGATAGTTATACGGACTTAGCAGTTCTAAAAATTAGTAGTGATAAAGTTGATAAAAC
AGCTACTTTTGGTGATTCATCTGCCTTGAAGGTTGGTGAACCTGCGATTGCGATTGGTTCGCCTTTAGGTTCCCAATATG
CTAACTCGGTTACCTCAGGGATTATTTCTTCTTTAAATCGCCAAGTTGCTGATTCTCAAACTGGCGTGAATATTAGTGCT
ATTCAAACTGACGCTGCGATTAACCCAGGAAATTCTGGTGGGCCATTAGTCAATATTGCCGGTCAAGTAATTGGTATTAA
CTCAAGTAAAATCGCCTCAACGAACTCTTCTAGTTCTGATATTAGCGTAGAAGGTATGGGTTTTGCAATTCCAAGTAATG
ACGTAGTTTCTATTATTAACCAACTTGAAAAAGATGGCAAAGTTACTCGTCCCGCTCTTGGTATTACCATGGTAGACTTA
TCAGCTGTAACATCACAACAACAAGAACAAATCTTAAAAGTACCTAGCTCCCTTAAAAACGGGGTTGTCATCACGACGGT
TCAAAATGCAACTCCGGCAGAACAAGCTGGCTTAAAACAATATGATGTGATTACTAAAATTGACGGCAAAGAAGTTGATT
CTACTTCTGATTTGCAATCAGCTTTATACAAGAAAAAAGTTGGCGATTCCATTGAAATCACGTACTACCGTGGTAGCAAA
GAACATACCACAAAAGTTTCATTGACGATTGATCAATCTGCTTTAAAGCAAAATAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(257-410)

PDZ domain (PDZ_2)

(311-408)

Trypsin-like peptidase domain (Trypsin_2)

(124-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB S1NA36

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

50.976

97.852

0.499
  htrA Streptococcus mutans UA159

55.556

88.067

0.489
  htrA Streptococcus pneumoniae D39

55.685

81.862

0.456
  htrA Streptococcus pneumoniae R6

55.685

81.862

0.456
  htrA Streptococcus pneumoniae TIGR4

55.685

81.862

0.456
  htrA Streptococcus pneumoniae Rx1

55.685

81.862

0.456
  htrA Streptococcus mitis NCTC 12261

55.685

81.862

0.456