Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   PML83_RS12615 Genome accession   NZ_CP116575
Coordinates   2564054..2565352 (+) Length   432 a.a.
NCBI ID   WP_010783616.1    Uniprot ID   -
Organism   Enterococcus faecalis strain K205-3     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2559054..2570352
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PML83_RS12590 (PML83_12590) - 2559540..2559767 (-) 228 Protein_2455 sigma-70 family RNA polymerase sigma factor -
  PML83_RS12595 (PML83_12595) gst 2559941..2560450 (-) 510 WP_002381118.1 DinB family glutathione transferase -
  PML83_RS12600 (PML83_12600) - 2560783..2562186 (+) 1404 WP_002383291.1 dicarboxylate/amino acid:cation symporter -
  PML83_RS12605 (PML83_12605) - 2562284..2563126 (-) 843 WP_002381116.1 LEM-3-like GIY-YIG domain-containing protein -
  PML83_RS12610 (PML83_12610) rlmH 2563174..2563653 (-) 480 WP_002355021.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  PML83_RS12615 (PML83_12615) htrA 2564054..2565352 (+) 1299 WP_010783616.1 S1C family serine protease Regulator
  PML83_RS12620 (PML83_12620) ytpR 2565399..2566019 (-) 621 WP_002361057.1 YtpR family tRNA-binding protein -
  PML83_RS12625 (PML83_12625) - 2566230..2566685 (-) 456 WP_002385249.1 universal stress protein -
  PML83_RS12630 (PML83_12630) - 2566833..2567147 (-) 315 WP_002355015.1 thioredoxin family protein -
  PML83_RS12635 (PML83_12635) pepA 2567159..2568235 (-) 1077 WP_002355013.1 glutamyl aminopeptidase -
  PML83_RS12640 (PML83_12640) - 2568542..2568883 (+) 342 WP_002381114.1 PepSY domain-containing protein -

Sequence

Protein


Download         Length: 432 a.a.        Molecular weight: 44859.02 Da        Isoelectric Point: 5.1187

>NTDB_id=778524 PML83_RS12615 WP_010783616.1 2564054..2565352(+) (htrA) [Enterococcus faecalis strain K205-3]
MQRKDVTPNSDKKSLLQKFGIGLAGGLLGGALILGGAYSGIIPTPNGGNNVATTTSTNHGDTKVSNVSYNVSSDVTKAVK
KVQNSVVSVINMQSASNNSSADDPFGGLFGGNEGTQDSSGNNGNDLEAASEGSGVIYKKDGKTAYVVTNNHVVDKAQGLE
VVLSDGTKVKGELVGTDAYTDLAVIKISSDKVNQVAEFGNSSKITVGEPAIAIGSPLGSDYANSVTQGIISSVNRNITNK
NESGETININAIQTDAAINPGNSGGPLINIEGQVIGINSVKIVQSTSQVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPA
LGITMSDLTGISSQQQEQILKIPASVKTGVVVRGVEAATPAEKAGLEKYDVITKVDGQDVSSTTDLQSALYKKKVGDKME
VTYYRGSKEMKATIDLTIDKSALTQQNNRSNQ

Nucleotide


Download         Length: 1299 bp        

>NTDB_id=778524 PML83_RS12615 WP_010783616.1 2564054..2565352(+) (htrA) [Enterococcus faecalis strain K205-3]
ATGCAACGAAAAGATGTTACACCTAATTCAGATAAAAAAAGTTTATTGCAAAAATTTGGGATTGGTTTAGCTGGCGGCTT
ACTTGGTGGCGCCCTTATTCTAGGAGGCGCTTATTCTGGGATTATTCCCACACCCAACGGCGGAAATAATGTGGCGACGA
CGACGTCCACTAATCACGGCGACACAAAAGTCAGCAATGTGAGTTACAATGTTTCTAGCGATGTCACAAAAGCCGTGAAA
AAAGTTCAAAATTCTGTGGTTTCTGTCATTAATATGCAAAGTGCTAGCAACAATTCTTCGGCAGATGATCCTTTTGGGGG
ATTGTTCGGTGGGAATGAAGGTACTCAAGACTCTTCCGGCAACAATGGTAACGATTTAGAAGCAGCCAGTGAAGGTAGTG
GGGTTATTTATAAGAAAGATGGTAAAACGGCTTATGTCGTGACAAATAACCACGTCGTAGATAAAGCGCAAGGATTGGAA
GTTGTTTTATCTGATGGTACCAAAGTGAAAGGCGAATTAGTCGGAACCGATGCTTACACGGATTTAGCCGTGATTAAAAT
TTCTTCTGACAAAGTTAATCAAGTCGCTGAGTTTGGGAATTCTAGTAAAATCACAGTCGGTGAGCCTGCTATTGCAATTG
GTTCCCCGCTAGGTTCTGATTATGCTAACTCTGTCACACAAGGAATCATCTCTTCTGTGAATAGAAATATTACCAATAAA
AATGAATCCGGTGAAACTATCAATATTAATGCCATTCAAACCGATGCTGCCATCAATCCAGGAAACTCTGGTGGTCCACT
AATCAATATTGAAGGACAAGTCATTGGCATTAACTCAGTAAAAATTGTGCAATCAACTAGTCAAGTGAGCGTTGAAGGGA
TGGGCTTTGCCATTCCAAGTAATGACGTAGTCAACATTATCAACCAATTAGAAAAAGATGGTAAAGTGACACGACCAGCT
CTTGGGATTACGATGTCTGATTTAACAGGTATCTCTTCACAACAACAAGAACAAATTTTAAAAATTCCAGCTTCTGTAAA
AACTGGCGTAGTGGTTCGTGGTGTTGAAGCAGCGACCCCTGCTGAAAAGGCTGGATTGGAAAAATACGATGTTATCACGA
AAGTTGACGGCCAAGACGTAAGCTCTACTACAGATTTACAAAGCGCGCTTTACAAGAAAAAAGTTGGCGACAAAATGGAA
GTGACTTATTATCGTGGTTCTAAAGAAATGAAAGCAACCATCGATTTAACCATTGATAAATCAGCTTTAACACAACAAAA
TAATCGCAGCAATCAATAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(132-277)

PDZ domain (PDZ_2)

(319-416)

Peptidase family M50 (Peptidase_M50)

(9-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.171

94.907

0.505
  htrA Streptococcus mutans UA159

58.63

84.491

0.495
  htrA Streptococcus mitis NCTC 12261

55.135

85.648

0.472
  htrA Streptococcus pneumoniae TIGR4

55.807

81.713

0.456
  htrA Streptococcus pneumoniae Rx1

55.807

81.713

0.456
  htrA Streptococcus pneumoniae D39

55.807

81.713

0.456
  htrA Streptococcus pneumoniae R6

55.807

81.713

0.456