Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   PML75_RS11605 Genome accession   NZ_CP116555
Coordinates   2453174..2454472 (+) Length   432 a.a.
NCBI ID   WP_002368406.1    Uniprot ID   R3K7C6
Organism   Enterococcus faecalis strain K70-12a     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2448174..2459472
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PML75_RS11600 (PML75_11600) rlmH 2452294..2452773 (-) 480 WP_002355021.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  PML75_RS11605 (PML75_11605) htrA 2453174..2454472 (+) 1299 WP_002368406.1 S1C family serine protease Regulator
  PML75_RS11610 (PML75_11610) ytpR 2454519..2455139 (-) 621 WP_010712879.1 YtpR family tRNA-binding protein -
  PML75_RS11615 (PML75_11615) - 2455243..2456067 (-) 825 WP_172759448.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
  PML75_RS11620 (PML75_11620) - 2456051..2456821 (-) 771 WP_002365320.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
  PML75_RS11625 (PML75_11625) - 2456843..2457316 (-) 474 WP_002359087.1 PTS sugar transporter subunit IIB -
  PML75_RS11630 (PML75_11630) - 2457319..2458062 (-) 744 WP_016635012.1 BtpA/SgcQ family protein -
  PML75_RS11635 (PML75_11635) - 2458074..2458484 (-) 411 WP_104807433.1 PTS sugar transporter subunit IIA -
  PML75_RS11640 (PML75_11640) - 2458499..2459230 (-) 732 WP_002365323.1 GntR family transcriptional regulator -

Sequence

Protein


Download         Length: 432 a.a.        Molecular weight: 44831.95 Da        Isoelectric Point: 4.9968

>NTDB_id=778228 PML75_RS11605 WP_002368406.1 2453174..2454472(+) (htrA) [Enterococcus faecalis strain K70-12a]
MQRKDVTPNSDKKSLLQKFGIGLAGGLLGGALILGGAYSGIIPTPNGGNNAATTTSTNHGDTKVSNVSYNVSSDVTKAVK
KVQNSVVSVINMQSASNNSSADDPFGGLFGGNEGTQDSSGNNGNDLEAASEGSGVIYKKDGKTAYVVTNNHVVDKAQGLE
VVLSDGTKVKGELVGTDAYTDLAVIKISSDKVDQVAEFGNSSKITVGEPAIAIGSPLGSDYANSVTQGIISSVNRNITNK
NESGETININAIQTDAAINPGNSGGPLINIEGQVIGINSVKIVQSTSQVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPA
LGITMSDLTGISSQQQEQILKIPASVKTGVVVRGVEAATPAEKAGLEKYDVITKVDGQDVSSTTDLQSALYKKKVGDKME
VTYYRGSKEMKATIDLTIDKSALTQQNNRSNQ

Nucleotide


Download         Length: 1299 bp        

>NTDB_id=778228 PML75_RS11605 WP_002368406.1 2453174..2454472(+) (htrA) [Enterococcus faecalis strain K70-12a]
ATGCAACGAAAAGATGTTACACCTAATTCAGATAAAAAAAGTTTATTGCAAAAATTTGGGATTGGTTTAGCTGGCGGCTT
ACTTGGTGGCGCTCTTATTCTAGGAGGCGCTTATTCTGGGATTATTCCCACACCCAACGGCGGAAATAATGCAGCGACGA
CGACGTCCACTAATCACGGCGACACAAAGGTCAGCAATGTGAGTTACAATGTGTCTAGCGATGTCACAAAAGCCGTGAAA
AAAGTTCAAAATTCTGTGGTTTCTGTCATTAATATGCAAAGTGCTAGCAACAATTCTTCGGCAGATGATCCTTTTGGGGG
ATTGTTCGGTGGGAATGAAGGTACGCAAGACTCTTCCGGCAACAATGGTAACGATTTAGAAGCAGCCAGTGAAGGTAGTG
GGGTTATTTATAAGAAAGATGGTAAAACGGCTTATGTCGTGACAAATAACCACGTCGTAGATAAAGCGCAAGGATTGGAA
GTTGTTTTGTCTGATGGTACCAAAGTGAAAGGCGAATTAGTCGGAACCGATGCTTATACGGATTTAGCCGTGATTAAAAT
TTCTTCCGACAAAGTTGATCAAGTCGCTGAGTTTGGGAATTCTAGTAAAATCACAGTCGGTGAGCCTGCGATTGCGATTG
GTTCCCCGCTAGGTTCTGATTATGCTAACTCTGTCACACAAGGAATCATCTCTTCTGTGAATAGAAATATTACCAATAAA
AACGAGTCTGGTGAAACCATCAATATTAATGCCATTCAAACCGATGCTGCTATTAATCCAGGAAACTCTGGTGGTCCACT
AATCAATATTGAAGGACAAGTCATTGGAATTAACTCAGTAAAAATTGTGCAATCAACTAGTCAAGTGAGCGTTGAAGGGA
TGGGCTTTGCCATTCCAAGTAATGACGTAGTCAACATTATCAACCAATTAGAAAAAGATGGTAAAGTGACGCGGCCAGCT
CTAGGGATTACGATGTCTGATTTAACAGGTATCTCTTCACAACAACAAGAACAAATTTTAAAAATTCCAGCTTCTGTAAA
AACTGGCGTAGTGGTTCGTGGTGTTGAAGCAGCGACCCCTGCTGAAAAGGCTGGATTGGAAAAATACGATGTTATCACGA
AAGTTGACGGCCAAGACGTAAGCTCTACTACAGATTTACAAAGCGCGCTTTACAAGAAAAAAGTTGGCGACAAAATGGAA
GTGACTTATTATCGTGGTTCTAAAGAAATGAAAGCAACCATCGATTTAACCATTGATAAATCAGCTTTAACACAACAAAA
TAATCGCAGCAATCAATAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(132-277)

Peptidase family M50 (Peptidase_M50)

(9-416)

PDZ domain (PDZ_2)

(319-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB R3K7C6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.171

94.907

0.505
  htrA Streptococcus mutans UA159

58.63

84.491

0.495
  htrA Streptococcus mitis NCTC 12261

55.135

85.648

0.472
  htrA Streptococcus pneumoniae TIGR4

55.807

81.713

0.456
  htrA Streptococcus pneumoniae Rx1

55.807

81.713

0.456
  htrA Streptococcus pneumoniae D39

55.807

81.713

0.456
  htrA Streptococcus pneumoniae R6

55.807

81.713

0.456