Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   PEZ79_RS01210 Genome accession   NZ_CP116023
Coordinates   244497..245780 (-) Length   427 a.a.
NCBI ID   WP_002324312.1    Uniprot ID   A0AB37VT26
Organism   Enterococcus faecium strain CQFYH22-006     
Function   repress competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 246233..294225 244497..245780 flank 453


Gene organization within MGE regions


Location: 244497..294225
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PEZ79_RS01210 (PEZ79_01210) htrA 244497..245780 (-) 1284 WP_002324312.1 trypsin-like peptidase domain-containing protein Regulator
  PEZ79_RS01215 (PEZ79_01215) rlmH 246233..246712 (+) 480 WP_002317110.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  PEZ79_RS01220 (PEZ79_01220) - 246915..247466 (+) 552 WP_010723382.1 PD-(D/E)XK nuclease family protein -
  PEZ79_RS01225 (PEZ79_01225) - 247537..248706 (+) 1170 WP_152133451.1 IS256-like element ISEfa13 family transposase -
  PEZ79_RS01230 (PEZ79_01230) - 249006..249698 (+) 693 WP_002294148.1 hypothetical protein -
  PEZ79_RS01235 (PEZ79_01235) - 250126..250518 (+) 393 WP_002287845.1 hypothetical protein -
  PEZ79_RS01240 (PEZ79_01240) - 250691..250894 (-) 204 Protein_248 IS256 family transposase -
  PEZ79_RS01245 (PEZ79_01245) - 250890..251057 (+) 168 WP_154067201.1 hypothetical protein -
  PEZ79_RS01250 (PEZ79_01250) - 251100..251675 (-) 576 WP_002287847.1 thymidine kinase -
  PEZ79_RS01255 (PEZ79_01255) - 251830..252356 (-) 527 Protein_251 transposase -
  PEZ79_RS01260 (PEZ79_01260) gadC 252813..254324 (+) 1512 WP_152133493.1 glutamate:gamma-aminobutyrate antiporter -
  PEZ79_RS01265 (PEZ79_01265) - 254337..255737 (+) 1401 WP_002287852.1 glutamate decarboxylase -
  PEZ79_RS01270 (PEZ79_01270) - 255902..257338 (-) 1437 WP_271291987.1 DNA-binding protein -
  PEZ79_RS01275 (PEZ79_01275) - 257731..258324 (+) 594 WP_002287856.1 ParB/RepB/Spo0J family partition protein -
  PEZ79_RS01280 (PEZ79_01280) - 258308..259470 (-) 1163 Protein_256 IS3 family transposase -
  PEZ79_RS01285 (PEZ79_01285) - 259702..260010 (+) 309 WP_002319282.1 DUF960 domain-containing protein -
  PEZ79_RS01290 (PEZ79_01290) - 260037..260336 (+) 300 WP_002317116.1 hypothetical protein -
  PEZ79_RS01295 (PEZ79_01295) - 260510..261061 (+) 552 WP_002312616.1 DUF1643 domain-containing protein -
  PEZ79_RS01300 (PEZ79_01300) - 261207..261500 (+) 294 WP_002328685.1 Mor transcription activator family protein -
  PEZ79_RS01305 (PEZ79_01305) - 261493..261789 (+) 297 WP_002304106.1 peptidase -
  PEZ79_RS01310 (PEZ79_01310) - 261868..262758 (+) 891 WP_024265255.1 DUF4767 domain-containing protein -
  PEZ79_RS01315 (PEZ79_01315) - 263352..263957 (+) 606 WP_045172145.1 Fic family protein -
  PEZ79_RS01320 (PEZ79_01320) - 264338..265396 (+) 1059 WP_104878857.1 hypothetical protein -
  PEZ79_RS01325 (PEZ79_01325) - 265872..266243 (+) 372 WP_002328107.1 hypothetical protein -
  PEZ79_RS01330 (PEZ79_01330) - 266236..267651 (+) 1416 WP_104876625.1 phage/plasmid primase, P4 family -
  PEZ79_RS01335 (PEZ79_01335) - 268080..268319 (+) 240 WP_096705500.1 hypothetical protein -
  PEZ79_RS01340 (PEZ79_01340) - 268335..269708 (+) 1374 WP_002337042.1 recombinase family protein -
  PEZ79_RS01345 (PEZ79_01345) - 269712..271349 (+) 1638 WP_002340112.1 recombinase family protein -
  PEZ79_RS01350 (PEZ79_01350) - 271512..271883 (+) 372 WP_002328114.1 hypothetical protein -
  PEZ79_RS12980 - 271855..272252 (+) 398 Protein_271 recombinase family protein -
  PEZ79_RS01360 (PEZ79_01360) - 272362..273957 (+) 1596 WP_086310353.1 type I restriction-modification system subunit M -
  PEZ79_RS01365 (PEZ79_01365) - 273947..275179 (+) 1233 WP_271291988.1 restriction endonuclease subunit S -
  PEZ79_RS01370 (PEZ79_01370) - 275192..278341 (+) 3150 WP_271291989.1 HsdR family type I site-specific deoxyribonuclease -
  PEZ79_RS01375 (PEZ79_01375) - 279048..279365 (-) 318 Protein_275 transposase -
  PEZ79_RS01380 (PEZ79_01380) - 279679..281607 (+) 1929 WP_271291990.1 BglG family transcription antiterminator -
  PEZ79_RS01385 (PEZ79_01385) - 281600..282064 (+) 465 WP_271291991.1 fructose PTS transporter subunit IIA -
  PEZ79_RS01390 (PEZ79_01390) - 282079..282393 (+) 315 WP_002375290.1 PTS fructose transporter subunit IIB -
  PEZ79_RS01395 (PEZ79_01395) - 282419..283480 (+) 1062 WP_002375292.1 PTS fructose transporter subunit IIC -
  PEZ79_RS01400 (PEZ79_01400) - 283534..284811 (+) 1278 WP_002375295.1 class II D-tagatose-bisphosphate aldolase, non-catalytic subunit -
  PEZ79_RS01405 (PEZ79_01405) fsa 284828..285472 (+) 645 WP_002375297.1 fructose-6-phosphate aldolase -
  PEZ79_RS01410 (PEZ79_01410) tkt 285531..287525 (+) 1995 Protein_282 transketolase -
  PEZ79_RS01415 (PEZ79_01415) rpiB 287574..288005 (+) 432 WP_271291992.1 ribose 5-phosphate isomerase B -
  PEZ79_RS01420 (PEZ79_01420) - 288088..288801 (+) 714 WP_025478579.1 HAD family hydrolase -
  PEZ79_RS01425 (PEZ79_01425) - 289032..290184 (+) 1153 Protein_285 IS256 family transposase -
  PEZ79_RS01430 (PEZ79_01430) - 290259..290957 (+) 699 WP_002400698.1 HAD family hydrolase -
  PEZ79_RS01435 (PEZ79_01435) - 291151..291600 (+) 450 Protein_287 transposase -
  PEZ79_RS01440 (PEZ79_01440) - 291682..292808 (+) 1127 WP_094850654.1 IS3 family transposase -
  PEZ79_RS01445 (PEZ79_01445) - 292909..293469 (-) 561 WP_002326412.1 TetR/AcrR family transcriptional regulator -
  PEZ79_RS01450 (PEZ79_01450) - 293611..294225 (+) 615 WP_002326413.1 GNAT family N-acetyltransferase -

Sequence

Protein


Download         Length: 427 a.a.        Molecular weight: 44453.55 Da        Isoelectric Point: 4.7976

>NTDB_id=775342 PEZ79_RS01210 WP_002324312.1 244497..245780(-) (htrA) [Enterococcus faecium strain CQFYH22-006]
MERKDVTPKMKKNNGIWRKLGLGLVGGIIGGLVTAGIFYAVMGSGNAASNSGGHQNSAGETVVENVKVNVDSDITNAVDK
VQDAVVSVINLQSQNQGTNGFGQLFGQQQESSDDSNLEASSEGSGVIYKKSGNSAYIVTNNHVVEGQQGLEVLLKDGTKV
KAELVGTDAYSDLAVLKISADKVNKVASFGDSNSLKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNQTVNI
NAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSASSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITMV
DLSAVSTQQQEQILKIPESVTNGVIVTSVQPATPAEKAGLKQYDVITKIDDTDVSSGVELQSVLYQKKVGDSVKVTYYRG
KEKKTTTIQLTIDQSALKQSQSENSGN

Nucleotide


Download         Length: 1284 bp        

>NTDB_id=775342 PEZ79_RS01210 WP_002324312.1 244497..245780(-) (htrA) [Enterococcus faecium strain CQFYH22-006]
ATGGAGAGAAAAGATGTGACACCAAAAATGAAAAAGAATAATGGAATCTGGCGTAAGCTGGGTCTAGGCTTAGTCGGTGG
AATTATTGGGGGCTTGGTAACGGCTGGTATTTTTTATGCTGTCATGGGTTCTGGAAACGCAGCGTCAAATTCGGGTGGTC
ATCAAAATTCAGCGGGCGAAACTGTCGTTGAGAATGTCAAAGTCAATGTCGATTCAGATATCACGAATGCGGTCGATAAA
GTCCAAGATGCGGTGGTATCTGTTATCAATCTTCAAAGCCAAAATCAAGGGACCAACGGCTTTGGTCAACTATTTGGCCA
ACAACAAGAAAGTTCTGATGATAGCAATCTAGAGGCTTCTAGTGAAGGTAGTGGTGTCATCTACAAAAAAAGTGGTAATT
CCGCTTATATCGTAACGAATAATCACGTAGTGGAAGGCCAACAAGGATTAGAAGTTTTATTAAAAGATGGAACAAAAGTC
AAAGCTGAATTAGTCGGGACGGATGCTTATTCTGACTTAGCCGTTTTGAAAATCAGTGCAGATAAAGTGAACAAAGTTGC
TTCATTTGGTGACTCTAATTCATTGAAAGTAGGTGAACCTGCGATCGCAATTGGTTCTCCTCTAGGTTCTGAATATGCCA
ACTCTGTGACTTCGGGGATCATCTCTTCATTGAATCGCCAAGTAACCAGCACGAACGAGTCAAATCAAACGGTCAATATC
AATGCGATCCAAACAGATGCTGCGATTAACCCTGGTAATTCTGGTGGTCCATTAGTTAATATTGAAGGACAAGTGATCGG
GATCAATTCAAGTAAAATTGCAAGTACTTCTGCTTCTTCATCAGGTGTAAGCGTGGAAGGAATGGGCTTTGCGATCCCAA
GTAACGATGTAGTAAATATTATCAACCAACTTGAAAAAGATGGAAAAGTAACCCGTCCTGCTCTAGGGATCACAATGGTT
GACCTTTCAGCCGTTTCAACCCAACAACAAGAACAAATCTTGAAAATTCCTGAGTCTGTGACAAATGGTGTGATTGTTAC
TAGCGTTCAACCGGCGACACCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTCATTACAAAAATCGATGATACTGATG
TTTCTTCTGGTGTAGAATTACAATCTGTCTTATATCAGAAAAAAGTCGGCGATTCAGTGAAGGTCACTTACTATCGCGGA
AAAGAAAAGAAAACAACAACGATTCAATTAACAATTGATCAATCCGCATTAAAACAAAGTCAATCAGAGAACTCTGGTAA
CTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(123-268)

PDZ domain (PDZ_2)

(313-410)

Peptidase family M50 (Peptidase_M50)

(12-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.483

94.145

0.504
  htrA Streptococcus mutans UA159

54.177

92.506

0.501
  htrA Streptococcus pneumoniae D39

58.631

78.689

0.461
  htrA Streptococcus pneumoniae TIGR4

58.631

78.689

0.461
  htrA Streptococcus pneumoniae R6

58.631

78.689

0.461
  htrA Streptococcus pneumoniae Rx1

58.631

78.689

0.461
  htrA Streptococcus mitis NCTC 12261

57.738

78.689

0.454