Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   O4N81_RS12265 Genome accession   NZ_CP114617
Coordinates   2508507..2509793 (+) Length   428 a.a.
NCBI ID   WP_002299298.1    Uniprot ID   A0A132P4Z0
Organism   Enterococcus faecium strain EF0656     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2503507..2514793
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  O4N81_RS12240 (O4N81_12240) - 2504679..2505098 (-) 420 WP_085811525.1 PTS sugar transporter subunit IIA -
  O4N81_RS12245 (O4N81_12245) - 2505111..2505920 (-) 810 WP_002301830.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
  O4N81_RS12250 (O4N81_12250) - 2505913..2506713 (-) 801 WP_002301831.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
  O4N81_RS12255 (O4N81_12255) - 2506728..2507204 (-) 477 WP_002301832.1 PTS system mannose/fructose/N-acetylgalactosamine-transporter subunit IIB -
  O4N81_RS12260 (O4N81_12260) rlmH 2507599..2508078 (-) 480 WP_002299297.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  O4N81_RS12265 (O4N81_12265) htrA 2508507..2509793 (+) 1287 WP_002299298.1 S1C family serine protease Regulator
  O4N81_RS12270 (O4N81_12270) ytpR 2509968..2510573 (-) 606 WP_002294153.1 YtpR family tRNA-binding protein -
  O4N81_RS12275 (O4N81_12275) - 2510778..2511242 (-) 465 WP_002287838.1 universal stress protein -
  O4N81_RS12280 (O4N81_12280) - 2511264..2511584 (-) 321 WP_002287837.1 thioredoxin family protein -
  O4N81_RS12285 (O4N81_12285) pepA 2511727..2512806 (-) 1080 WP_002294156.1 glutamyl aminopeptidase -
  O4N81_RS12290 (O4N81_12290) - 2513006..2513356 (+) 351 WP_002289862.1 PepSY domain-containing protein -
  O4N81_RS12295 (O4N81_12295) - 2513605..2514513 (+) 909 WP_002295743.1 IS982-like element ISEfm1 family transposase -

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44827.86 Da        Isoelectric Point: 4.5950

>NTDB_id=766896 O4N81_RS12265 WP_002299298.1 2508507..2509793(+) (htrA) [Enterococcus faecium strain EF0656]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTTSGNQNSAGETVVENVKVNVDSDITKAV
DKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKDG
TKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNET
VNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGI
TMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKKYDVITKIDDKEVSSGVELQSALYKKKVGDSVKITY
YEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=766896 O4N81_RS12265 WP_002299298.1 2508507..2509793(+) (htrA) [Enterococcus faecium strain EF0656]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTAGGGCTTGT
TGGAGGGATCGTTGGAGGATTACTGACAGCTGGTATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTACAA
GTGGCAATCAAAATTCTGCTGGTGAAACAGTTGTGGAAAACGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCAGTA
GATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTGCAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATTCGG
GCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAAAAG
ACGGGAATACTGCTTATGTAGTCACAAACAACCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGACGGT
ACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGTCGA
AACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCATTAGGATCTG
AATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACAAATGAATCGAACGAAACA
GTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTGAATATCGAAGGACA
AGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGATTTG
CTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGTATC
ACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGGTGT
CATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAAAAATACGACGTCATTACTAAGATCGATG
ACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACTTAC
TATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAGTGA
AAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(316-413)

Trypsin-like peptidase domain (Trypsin_2)

(126-271)

Peptidase family M50 (Peptidase_M50)

(10-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A132P4Z0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.962

91.822

0.505
  htrA Streptococcus mutans UA159

60.169

82.71

0.498
  htrA Streptococcus mitis NCTC 12261

52.897

92.757

0.491
  htrA Streptococcus pneumoniae TIGR4

59.347

78.738

0.467
  htrA Streptococcus pneumoniae D39

59.347

78.738

0.467
  htrA Streptococcus pneumoniae Rx1

59.347

78.738

0.467
  htrA Streptococcus pneumoniae R6

59.347

78.738

0.467