Detailed information NTG0766390

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: O0957_RS05455
• Genome accession: NZ_CP114552
• Coordinates: 1053903..1056065 (+)
• Length: 720 a.a.
• NCBI ID: WP_035460587.1
• Uniprot ID: A0A4Q0LSZ9
• Organism: Lactobacillus crispatus strain Lcr-MH175
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1048903..1061065

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
O0957_RS05425 (O0957_05425)	-	1049307..1049792 (+)	486	WP_005718156.1	hypothetical protein	-
O0957_RS05430 (O0957_05430)	-	1049789..1049986 (+)	198	WP_005718157.1	helix-turn-helix transcriptional regulator	-
O0957_RS05435 (O0957_05435)	-	1050132..1051166 (-)	1035	WP_005728483.1	IS30 family transposase	-
O0957_RS05440 (O0957_05440)	-	1051538..1051684 (+)	147	WP_005718160.1	hypothetical protein	-
O0957_RS05445 (O0957_05445)	-	1051688..1053094 (+)	1407	WP_005718161.1	sensor histidine kinase	-
O0957_RS05450 (O0957_05450)	-	1053098..1053922 (+)	825	WP_005718162.1	LytR/AlgR family response regulator transcription factor	-
O0957_RS05455 (O0957_05455)	comA	1053903..1056065 (+)	2163	WP_035460587.1	peptide cleavage/export ABC transporter	Regulator
O0957_RS05460 (O0957_05460)	-	1056075..1056713 (+)	639	WP_005718164.1	HlyD family efflux transporter periplasmic adaptor subunit	-
O0957_RS05465 (O0957_05465)	-	1056921..1057100 (+)	180	WP_005718165.1	hypothetical protein	-
O0957_RS05470 (O0957_05470)	-	1057460..1057618 (+)	159	WP_164913815.1	hypothetical protein	-
O0957_RS05475 (O0957_05475)	-	1057662..1057802 (+)	141	WP_020993067.1	bacteriocin	-
O0957_RS05480 (O0957_05480)	-	1058055..1058852 (+)	798	WP_020993066.1	CPBP family intramembrane glutamic endopeptidase	-
O0957_RS05485 (O0957_05485)	-	1058930..1059202 (+)	273	WP_005718171.1	bacteriocin immunity protein	-

Sequence

Protein

• Length: 720 a.a.
• Molecular weight: 81040.60 Da
• Isoelectric Point: 9.6630

>NTDB_id=766390 O0957_RS05455 WP_035460587.1 1053903..1056065(+) (comA) [Lactobacillus crispatus strain Lcr-MH175]
MGMLTYKSIYVPQIDETDCGAACLAMILKNYHSQVSIAHLRHIAKTNTEGTTALGLVKTAEKFNMDVQAVKADMSLFNMK
DIQYPFIVHVIKDGGLLHYYVVLKSTKRKIIVADPDPTSGIKKMSKKAFEKEWTGITLFMVPKADFKPVKEKKNNLLSLF
PYMFKQKKLVRNIILAALLMTLISICSSYFVQGLIDTYIPNGTFTTLSVLAIGLLIAYVFNSIFSYGQQFLLNVLGQRLS
IDLNLQYIKHIFELPMEFFTTRKTGEITSRFSDASRIIDALASTVISLFLDLSIVILMGIILAVQNMTLFLITLASLPLY
AIVILGFSKRFERLNNDQMESNAVVSSSIIEDIQGIETIKALNSEQVRYRKIDSQFVDYLKKAFKYSKTEAFQTALKTFI
RLSLNVIILWVGASVVMHNQMSIGELMAFNALLSYFIDPLQNIINLQPTLQAANVAQNRLNEVYLVQSEFKGKTSVNDSH
DLNGDINFSHVDYRYGYGEDVLKDINLTIKDNEKLTIVGMSGSGKSTMVKLLVDFFSPTKGKVTFNGHSTRSINKHVLRS
YVNYVPQTPYIFAGTIKENLLLGSRKNITEKEIEEACQIAEIKNDIEKLPLGFNTQLDENAKILSGGQKQRLTIARALLS
PAKVLIFDEATSGLDTITEKKVVDNLIRLKNKTVIFIAHRLAIAERTDNIVVLNQGQVVEQGNHNELMKKRGYYYNLVKS

Nucleotide

• Length: 2163 bp

>NTDB_id=766390 O0957_RS05455 WP_035460587.1 1053903..1056065(+) (comA) [Lactobacillus crispatus strain Lcr-MH175]
ATGGGCATGTTAACGTATAAATCAATTTATGTTCCACAAATCGATGAAACAGACTGTGGTGCAGCTTGTTTAGCAATGAT
CTTAAAGAATTATCATTCTCAAGTATCAATAGCACATTTACGTCATATTGCTAAAACCAATACTGAAGGAACTACTGCTT
TAGGATTAGTTAAAACTGCGGAAAAATTCAATATGGATGTTCAAGCGGTAAAAGCAGATATGTCCTTATTCAATATGAAA
GATATTCAATATCCTTTTATTGTTCATGTGATAAAAGATGGAGGATTGTTACATTATTATGTAGTTCTTAAAAGTACTAA
AAGAAAAATAATCGTAGCCGATCCTGATCCTACTAGTGGAATTAAAAAAATGTCCAAAAAGGCGTTTGAAAAAGAGTGGA
CAGGTATTACATTGTTTATGGTGCCTAAGGCAGATTTTAAGCCTGTAAAGGAGAAAAAGAATAATCTATTATCATTATTC
CCTTATATGTTTAAACAGAAAAAGTTAGTTAGAAACATTATTTTAGCTGCTTTGCTGATGACACTGATTAGTATCTGTAG
CTCATATTTTGTACAAGGGTTGATTGATACATATATTCCTAACGGTACATTTACCACGTTATCTGTTTTAGCTATTGGGT
TATTGATTGCATATGTCTTTAACTCAATTTTTTCATATGGTCAGCAATTTTTATTGAATGTTTTGGGGCAGCGGTTATCA
ATCGATCTTAATTTACAATACATTAAGCATATTTTTGAATTACCGATGGAATTTTTTACTACCAGAAAAACTGGTGAGAT
TACTTCTCGTTTTTCTGATGCAAGTAGAATTATAGATGCATTGGCAAGTACGGTGATTTCATTATTCCTTGATCTTTCAA
TTGTAATTTTAATGGGTATAATTTTGGCGGTTCAAAACATGACATTGTTTTTGATTACGCTAGCTTCATTACCACTCTAT
GCTATTGTTATTCTCGGCTTTTCAAAAAGGTTTGAAAGATTAAATAATGACCAGATGGAAAGTAATGCGGTAGTTAGTTC
ATCAATTATTGAAGATATTCAAGGAATTGAGACGATTAAAGCATTAAACAGTGAACAAGTACGTTATCGAAAAATTGATA
GTCAGTTTGTTGATTATTTAAAAAAAGCTTTTAAGTATAGCAAAACAGAAGCTTTTCAAACTGCTTTGAAAACTTTTATT
AGATTATCACTGAATGTCATTATTCTTTGGGTGGGGGCAAGTGTTGTAATGCATAATCAAATGTCTATTGGTGAATTGAT
GGCATTTAATGCATTATTATCATATTTTATTGATCCATTACAAAATATTATTAACTTGCAACCTACACTTCAAGCTGCAA
ATGTAGCTCAGAATCGTTTAAATGAAGTTTATTTAGTTCAAAGTGAATTTAAGGGCAAAACTTCAGTTAATGATAGTCAT
GATTTAAATGGAGACATTAATTTCTCACATGTCGATTATCGTTATGGATATGGTGAAGATGTCTTAAAAGATATTAATTT
GACGATCAAAGATAATGAGAAATTAACTATTGTGGGAATGAGTGGATCAGGTAAGTCAACTATGGTTAAATTGTTGGTTG
ATTTTTTCAGTCCCACAAAAGGAAAAGTAACTTTTAATGGTCATTCGACTAGAAGTATAAATAAGCATGTTTTACGCTCA
TATGTGAATTATGTGCCACAAACTCCATATATTTTTGCAGGTACCATTAAAGAGAATCTTTTGTTGGGAAGTCGTAAGAA
TATAACTGAAAAAGAGATAGAAGAAGCTTGCCAAATCGCGGAGATAAAGAATGACATTGAAAAATTGCCATTAGGATTTA
ATACACAATTAGATGAAAATGCTAAGATTTTGTCAGGTGGTCAGAAGCAAAGATTAACAATTGCTAGGGCCTTACTTTCA
CCTGCTAAGGTATTGATTTTTGATGAAGCAACAAGTGGGCTTGATACAATTACTGAGAAAAAAGTGGTTGATAATTTAAT
TAGGTTAAAGAATAAAACTGTTATATTTATTGCGCATCGTTTAGCTATTGCTGAGAGAACTGACAATATTGTGGTATTGA
ATCAAGGTCAAGTTGTAGAACAAGGTAATCATAACGAATTAATGAAAAAGCGTGGCTATTATTACAATTTGGTGAAAAGT
TAG

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (173-440)

• Peptidase C39 family (Peptidase_C39) (10-144)

• ABC transporter (ABC_tran) (502-652)

3D structure

• AlphaFold DB: A0A4Q0LSZ9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	55.322	99.167	0.549
comA	Streptococcus pneumoniae Rx1	55.182	99.167	0.547
comA	Streptococcus pneumoniae D39	55.182	99.167	0.547
comA	Streptococcus pneumoniae R6	55.182	99.167	0.547
comA	Streptococcus pneumoniae TIGR4	55.042	99.167	0.546
comA	Streptococcus mitis SK321	54.902	99.167	0.544
comA	Streptococcus gordonii str. Challis substr. CH1	54.202	99.167	0.538
comA/nlmT	Streptococcus mutans UA159	54.031	98.194	0.531