Detailed information NTG0766389

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: O0957_RS05280
• Genome accession: NZ_CP114552
• Coordinates: 1024166..1026328 (+)
• Length: 720 a.a.
• NCBI ID: WP_005720995.1
• Uniprot ID: A0A135ZGN3
• Organism: Lactobacillus crispatus strain Lcr-MH175
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1019166..1031328

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
O0957_RS05260 (O0957_05260)	-	1020287..1021684 (+)	1398	WP_005720989.1	ATP-binding protein	-
O0957_RS05265 (O0957_05265)	-	1021802..1021933 (+)	132	WP_005720990.1	bacteriocin-like peptide, LSEI_2386 family	-
O0957_RS05270 (O0957_05270)	-	1021921..1023249 (+)	1329	WP_005720992.1	GHKL domain-containing protein	-
O0957_RS05275 (O0957_05275)	-	1023242..1024042 (+)	801	WP_005720993.1	LytR/AlgR family response regulator transcription factor	-
O0957_RS05280 (O0957_05280)	comA	1024166..1026328 (+)	2163	WP_005720995.1	peptide cleavage/export ABC transporter	Regulator
O0957_RS05285 (O0957_05285)	-	1026339..1026935 (+)	597	WP_005720997.1	hypothetical protein	-
O0957_RS05290 (O0957_05290)	-	1027090..1028394 (+)	1305	WP_005721000.1	thioredoxin domain-containing protein	-
O0957_RS05295 (O0957_05295)	-	1028395..1028592 (+)	198	WP_005721002.1	hypothetical protein	-
O0957_RS05300 (O0957_05300)	-	1029185..1029436 (+)	252	WP_005726423.1	Blp family class II bacteriocin	-
O0957_RS05305 (O0957_05305)	-	1029454..1029648 (+)	195	WP_005721006.1	bacteriocin	-
O0957_RS05310 (O0957_05310)	-	1029718..1029933 (+)	216	WP_005721007.1	hypothetical protein	-
O0957_RS05315 (O0957_05315)	-	1030101..1030283 (+)	183	WP_005721008.1	hypothetical protein	-
O0957_RS05320 (O0957_05320)	-	1030387..1030827 (+)	441	WP_224061526.1	DUF2975 domain-containing protein	-
O0957_RS05325 (O0957_05325)	-	1030842..1031051 (+)	210	WP_003549779.1	helix-turn-helix domain-containing protein	-

Sequence

Protein

• Length: 720 a.a.
• Molecular weight: 81317.69 Da
• Isoelectric Point: 8.1038

>NTDB_id=766389 O0957_RS05280 WP_005720995.1 1024166..1026328(+) (comA) [Lactobacillus crispatus strain Lcr-MH175]
MLLQYKSIYVPQVDESDCGVACLAMILKKYHSRVFLAHLRHSARTNLEGTTALGLVKTAQAFNLKTEAVKADMSLFDPDA
DIQYPFIVHVLKQGELLHYYVVIKATKNYLVIADPDPSVGLTKMSKEKFSQEWTGIALFMVPNDDFEPLKEKKQNLWSLF
PYMFKQKKLVTNIILAALLMTIISICSSYFLQGLIDTYIPSGTYQTLSILAIGLLIAYVFNSIFSYGQNFLLDVLGQRLS
IDLNLQYIRHIFELPMEFFVTRRTGEITSRFSDASRIIDALASTVISLFLDLSIVIVMGIVLAIQNSTLFVITLLSLPIY
AVVILSFSKKFEKMNNDQMESNAVLSSSVIEDIQGIETIKALNSEQTRYRKIDSQFVDYLKKSFRYSKTESLQSALKTFI
QLSLNVIILWVGAKVVMNGQMSIGQLMTFNALLSYFVDPLQSIINLQPTLQSANVAQNRLNEVYMVKSEFQKDAQIRDAK
QLAGEIEYHHVDYHYGYGVDVLKDINLKIEPNDKLAIVGMSGSGKSTMVKLLVDFFSPSKGKLTFNGFNSTKVDKHVLRS
YVNYVPQTPYIFSGTIKENLLLGSRPDITEKDILKACQIAEIESEIEQLPLQFETKMDENAKILSGGQKQRLTIARALLS
PAKILIFDEATSGLDTITEKKVVDNLMKLKDKTIIFIAHRLAIAQRTNNILVVDHGQIVEQGSHEKLMQKHGFYYNLVEN

Nucleotide

• Length: 2163 bp

>NTDB_id=766389 O0957_RS05280 WP_005720995.1 1024166..1026328(+) (comA) [Lactobacillus crispatus strain Lcr-MH175]
ATGTTACTACAGTATAAATCAATTTATGTACCACAAGTAGACGAATCAGATTGTGGAGTTGCATGCTTAGCTATGATTCT
TAAAAAATATCATTCTAGAGTATTTTTAGCCCATTTACGTCATTCAGCCCGCACTAATTTAGAAGGGACTACCGCTCTGG
GCTTAGTTAAAACAGCACAAGCATTTAATCTAAAAACTGAAGCAGTTAAAGCTGACATGTCCTTGTTTGATCCTGATGCA
GACATTCAATATCCTTTCATCGTACACGTCTTAAAGCAAGGCGAATTACTCCACTATTATGTTGTGATTAAGGCAACCAA
AAATTATTTAGTGATTGCTGATCCGGATCCTAGCGTTGGTTTAACGAAAATGTCTAAAGAAAAGTTTTCTCAAGAATGGA
CGGGAATTGCCCTTTTTATGGTCCCAAATGATGATTTTGAGCCACTCAAAGAGAAAAAGCAAAATCTGTGGTCACTATTT
CCATACATGTTCAAACAAAAGAAACTAGTCACTAATATTATTTTGGCTGCTCTTTTGATGACAATCATTAGTATTTGTAG
CTCATACTTCTTGCAAGGCTTAATTGATACTTATATTCCTAGCGGTACATACCAAACTTTGTCGATCCTAGCTATTGGTT
TATTGATAGCATATGTTTTCAACTCTATCTTTTCTTACGGGCAAAATTTTCTATTGGATGTTCTAGGTCAGCGATTAAGT
ATTGATCTTAACTTACAATACATTCGCCATATTTTTGAATTACCAATGGAATTCTTCGTAACTCGTAGAACAGGGGAAAT
TACCTCAAGGTTCTCTGATGCTAGTCGAATTATTGACGCACTCGCCAGTACAGTTATTTCATTATTTCTTGATCTTTCAA
TTGTAATTGTGATGGGAATAGTTTTGGCAATTCAAAATTCCACTCTATTTGTGATTACTCTACTGTCTTTGCCAATTTAT
GCAGTGGTGATTCTTAGCTTTTCTAAGAAATTTGAAAAGATGAATAATGATCAGATGGAGAGTAATGCTGTCTTAAGTTC
TTCAGTAATTGAAGATATTCAAGGAATTGAAACAATCAAAGCTTTAAATAGCGAACAAACACGTTATCGTAAGATTGATA
GTCAATTCGTCGATTACCTCAAGAAATCTTTTCGTTACAGTAAAACTGAATCTTTGCAGTCAGCTTTAAAGACCTTCATT
CAGTTATCTCTCAATGTAATTATCCTCTGGGTAGGGGCTAAGGTTGTAATGAACGGGCAGATGAGCATTGGTCAATTAAT
GACCTTCAACGCATTACTATCGTATTTTGTAGATCCACTTCAGAGCATTATTAATCTTCAACCAACTCTACAATCAGCTA
ATGTAGCACAAAATCGATTGAATGAAGTATACATGGTTAAGAGTGAGTTCCAGAAAGATGCTCAGATTAGGGATGCCAAG
CAATTAGCAGGTGAGATTGAATATCATCATGTTGACTATCATTATGGCTATGGAGTCGATGTATTAAAAGATATTAATTT
AAAAATCGAACCCAATGATAAGTTGGCAATCGTAGGGATGAGTGGCTCAGGTAAGTCTACTATGGTCAAACTTTTAGTTG
ATTTCTTCTCTCCAAGCAAAGGCAAGTTAACTTTTAATGGATTTAATTCTACTAAAGTAGATAAGCATGTCTTACGGTCA
TACGTAAACTATGTTCCCCAAACACCATACATCTTCTCAGGAACAATCAAAGAAAATCTGCTCTTAGGTAGTCGACCAGA
TATTACAGAAAAAGATATATTGAAAGCCTGTCAGATAGCAGAAATTGAGTCTGAAATCGAACAATTACCACTGCAGTTTG
AAACCAAGATGGATGAAAATGCCAAGATTTTATCCGGTGGGCAAAAGCAAAGGCTAACTATTGCACGTGCATTATTGTCA
CCGGCTAAAATTTTAATTTTTGATGAAGCCACTAGCGGGCTTGATACGATTACAGAGAAAAAAGTAGTAGATAATTTAAT
GAAATTAAAAGATAAAACTATTATTTTTATTGCTCATCGTTTAGCAATTGCACAAAGGACTAACAATATTCTGGTTGTAG
ATCATGGTCAAATTGTTGAGCAAGGAAGTCATGAGAAATTAATGCAGAAACATGGCTTTTACTATAACTTAGTTGAGAAT
TAG

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (171-440)

• ABC transporter (ABC_tran) (502-652)

• Peptidase C39 family (Peptidase_C39) (9-144)

3D structure

• AlphaFold DB: A0A135ZGN3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis SK321	56.643	99.306	0.562
comA	Streptococcus pneumoniae D39	56.503	99.306	0.561
comA	Streptococcus pneumoniae R6	56.503	99.306	0.561
comA	Streptococcus mitis NCTC 12261	56.503	99.306	0.561
comA	Streptococcus pneumoniae Rx1	56.503	99.306	0.561
comA	Streptococcus pneumoniae TIGR4	56.364	99.306	0.56
comA	Streptococcus gordonii str. Challis substr. CH1	55.664	99.306	0.553
comA/nlmT	Streptococcus mutans UA159	53.814	98.333	0.529