Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   OQG81_RS11195 Genome accession   NZ_CP113440
Coordinates   2127091..2127774 (+) Length   227 a.a.
NCBI ID   WP_099390332.1    Uniprot ID   -
Organism   Streptococcus macedonicus strain E37     
Function   repress competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 2116016..2137137 2127091..2127774 within 0
IScluster/Tn 2117820..2126165 2127091..2127774 flank 926


Gene organization within MGE regions


Location: 2116016..2137137
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OQG81_RS11135 (OQG81_11130) - 2116016..2116300 (-) 285 WP_230937540.1 hypothetical protein -
  OQG81_RS11140 (OQG81_11135) - 2116365..2116499 (-) 135 WP_006531373.1 hypothetical protein -
  OQG81_RS11145 (OQG81_11140) cadX 2116546..2116884 (-) 339 WP_006531372.1 Cd(II)/Zn(II)-sensing metalloregulatory transcriptional regulator CadX -
  OQG81_RS11150 (OQG81_11145) - 2116896..2117510 (-) 615 WP_322783395.1 CadD family cadmium resistance transporter -
  OQG81_RS11155 (OQG81_11150) - 2117820..2118995 (-) 1176 WP_265644278.1 IS256-like element IS1191 family transposase -
  OQG81_RS11160 (OQG81_11155) - 2119538..2121712 (-) 2175 WP_265643888.1 heavy metal translocating P-type ATPase -
  OQG81_RS11165 (OQG81_11160) - 2121731..2121868 (-) 138 Protein_2145 CopY/TcrY family copper transport repressor -
  OQG81_RS11170 (OQG81_11165) - 2122099..2123541 (-) 1443 WP_252534429.1 multicopper oxidase family protein -
  OQG81_RS11175 (OQG81_11170) - 2123689..2124833 (+) 1145 WP_265643889.1 IS3 family transposase -
  OQG81_RS11180 (OQG81_11175) - 2124990..2126165 (-) 1176 WP_269441521.1 IS256-like element IS1191 family transposase -
  OQG81_RS11185 (OQG81_11180) - 2126357..2126491 (-) 135 Protein_2149 IS256 family transposase -
  OQG81_RS11190 (OQG81_11185) - 2126752..2126913 (+) 162 Protein_2150 multicopper oxidase domain-containing protein -
  OQG81_RS12285 - 2126993..2127055 (+) 63 WP_081469455.1 multicopper oxidase domain-containing protein -
  OQG81_RS11195 (OQG81_11190) micA 2127091..2127774 (+) 684 WP_099390332.1 response regulator transcription factor Regulator
  OQG81_RS11200 (OQG81_11195) - 2127771..2129125 (+) 1355 Protein_2153 sensor histidine kinase -
  OQG81_RS11210 (OQG81_11205) - 2129296..2130504 (-) 1209 WP_099412071.1 YncE family protein -
  OQG81_RS11215 (OQG81_11210) lgt 2131015..2131899 (-) 885 WP_265643891.1 prolipoprotein diacylglyceryl transferase -
  OQG81_RS11220 (OQG81_11215) - 2131979..2132335 (-) 357 WP_265643892.1 M23 family metallopeptidase -
  OQG81_RS11225 (OQG81_11220) - 2132652..2132855 (+) 204 WP_043914323.1 adhesion protein -
  OQG81_RS11230 (OQG81_11225) - 2132908..2133510 (+) 603 WP_099390336.1 TIGR01906 family membrane protein -
  OQG81_RS11235 (OQG81_11230) - 2133684..2135786 (-) 2103 WP_214301982.1 heavy metal translocating P-type ATPase -
  OQG81_RS11240 (OQG81_11235) tcrZ 2135925..2136131 (-) 207 WP_002294571.1 copper chaperone TcrZ -
  OQG81_RS11245 (OQG81_11240) - 2136211..2136719 (-) 509 Protein_2161 HAD-IC family P-type ATPase -

Sequence

Protein


Download         Length: 227 a.a.        Molecular weight: 25664.71 Da        Isoelectric Point: 4.9111

>NTDB_id=762315 OQG81_RS11195 WP_099390332.1 2127091..2127774(+) (micA) [Streptococcus macedonicus strain E37]
MKILIVDDEASILDIVEAYLSAKGYQVFRALSGNEALTKVDVVQPDLIVLDLMLPGLSGLEVCKKIRDSSTVPIIMLTAK
TAEKDILEGLSLGADDYITKPFSPKELVARVETVLRRVQPEYREEKWSFEEGLLVIYPDRKQVFKQGEEIILTPTEYALL
ALLASHPKRLFSREQLLDAVKGLDFDGTDRVIDTHIKNIRQKIEDDTRNPYFILTAYGMGYRFGGQK

Nucleotide


Download         Length: 684 bp        

>NTDB_id=762315 OQG81_RS11195 WP_099390332.1 2127091..2127774(+) (micA) [Streptococcus macedonicus strain E37]
GTGAAGATTTTAATTGTGGACGACGAAGCAAGCATTCTGGATATCGTGGAAGCCTATTTGAGTGCAAAAGGCTATCAAGT
GTTTCGCGCTTTGAGCGGAAACGAGGCTTTAACAAAGGTTGATGTTGTCCAACCTGACTTGATTGTGTTGGATCTCATGC
TGCCTGGTTTATCTGGCCTCGAAGTCTGTAAAAAAATAAGGGACTCCTCCACTGTACCGATTATCATGTTGACTGCGAAA
ACAGCCGAAAAAGATATCTTGGAAGGGTTAAGCCTGGGGGCTGATGACTACATCACAAAACCATTCAGCCCGAAAGAGCT
GGTTGCTCGGGTCGAAACCGTTTTACGCCGTGTCCAACCAGAATACCGAGAAGAAAAGTGGTCTTTCGAAGAAGGTTTGC
TGGTTATCTACCCGGATCGAAAACAAGTATTCAAACAAGGTGAAGAAATCATTTTGACCCCGACTGAGTATGCTTTATTA
GCCCTTCTGGCCTCACATCCAAAGCGCCTATTTTCACGGGAACAGCTGCTGGACGCTGTGAAAGGACTCGATTTTGATGG
AACGGATCGGGTGATCGATACCCACATCAAAAATATCCGTCAAAAAATTGAGGACGACACGCGCAACCCCTACTTCATCT
TAACCGCATATGGAATGGGGTATCGATTTGGTGGTCAAAAATGA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-223)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

48.673

99.559

0.485
  vicR Streptococcus mutans UA159

48.458

100

0.485
  scnR Streptococcus mutans UA159

38.865

100

0.392
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.117

98.238

0.374
  covR Streptococcus salivarius strain HSISS4

37.668

98.238

0.37