Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   OTB22_RS05600 Genome accession   NZ_CP113267
Coordinates   1106198..1106935 (-) Length   245 a.a.
NCBI ID   WP_000782677.1    Uniprot ID   A0A0U0DTC6
Organism   Streptococcus pneumoniae strain BC2     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1101198..1111935
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OTB22_RS05580 (OTB22_05585) msrB 1102656..1103594 (-) 939 WP_000818203.1 peptide-methionine (R)-S-oxide reductase MsrB -
  OTB22_RS05585 (OTB22_05590) - 1103623..1103814 (-) 192 WP_001808580.1 hypothetical protein -
  OTB22_RS05590 (OTB22_05595) thrB 1103890..1104759 (-) 870 WP_000692438.1 homoserine kinase -
  OTB22_RS05595 (OTB22_05600) - 1104761..1106047 (-) 1287 WP_000216385.1 homoserine dehydrogenase -
  OTB22_RS05600 (OTB22_05605) mecA 1106198..1106935 (-) 738 WP_000782677.1 adaptor protein MecA Regulator
  OTB22_RS05605 (OTB22_05610) - 1107077..1108111 (-) 1035 WP_000461502.1 hypothetical protein -
  OTB22_RS05610 (OTB22_05615) - 1108140..1109573 (-) 1434 WP_000565088.1 O-antigen polysaccharide polymerase Wzy family protein -
  OTB22_RS05615 (OTB22_05620) - 1109589..1110575 (-) 987 WP_050233468.1 glycosyltransferase family 2 protein -
  OTB22_RS05620 (OTB22_05625) - 1110577..1111680 (-) 1104 WP_000225892.1 glycosyltransferase -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28395.21 Da        Isoelectric Point: 4.0236

>NTDB_id=761475 OTB22_RS05600 WP_000782677.1 1106198..1106935(-) (mecA) [Streptococcus pneumoniae strain BC2]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFAEDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=761475 OTB22_RS05600 WP_000782677.1 1106198..1106935(-) (mecA) [Streptococcus pneumoniae strain BC2]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAACAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGAGGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTTTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0U0DTC6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.184

100

0.992
  mecA Streptococcus pneumoniae D39

99.184

100

0.992
  mecA Streptococcus pneumoniae R6

99.184

100

0.992
  mecA Streptococcus pneumoniae TIGR4

98.776

100

0.988
  mecA Streptococcus thermophilus LMD-9

47.791

100

0.486
  mecA Streptococcus thermophilus LMG 18311

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482