Detailed information NTG0761462

Bioinformatically predicted

Overview

• Name: stkP
• Type: Regulator
• Locus tag: OTB22_RS02435
• Genome accession: NZ_CP113267
• Coordinates: 471665..473644 (+)
• Length: 659 a.a.
• NCBI ID: WP_000614538.1
• Uniprot ID: A0A0B7L145
• Organism: Streptococcus pneumoniae strain BC2
• Function: require for competence development; phosphorylate ComE (predicted from homology) Competence regulation

Genomic Context

Location: 466665..478644

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OTB22_RS02420 (OTB22_02425)	fmt	468672..469607 (+)	936	WP_000163693.1	methionyl-tRNA formyltransferase	-
OTB22_RS02425 (OTB22_02430)	rsmB	469600..470913 (+)	1314	WP_268218013.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
OTB22_RS02430 (OTB22_02435)	-	470928..471668 (+)	741	WP_000406247.1	Stp1/IreP family PP2C-type Ser/Thr phosphatase	-
OTB22_RS02435 (OTB22_02440)	stkP	471665..473644 (+)	1980	WP_000614538.1	serine/threonine-protein kinase StkP	Regulator
OTB22_RS02440 (OTB22_02445)	-	473759..474517 (+)	759	WP_000392877.1	threonine/serine exporter family protein	-
OTB22_RS02445 (OTB22_02450)	-	474519..474968 (+)	450	WP_000176924.1	threonine/serine exporter family protein	-
OTB22_RS02450 (OTB22_02455)	-	475030..475653 (+)	624	Protein_486	transposase family protein	-
OTB22_RS02455 (OTB22_02460)	-	475721..475969 (+)	249	WP_001818278.1	hypothetical protein	-
OTB22_RS02460 (OTB22_02465)	-	476100..477272 (+)	1173	WP_000151960.1	hydroxymethylglutaryl-CoA synthase	-
OTB22_RS02465 (OTB22_02470)	-	477272..478546 (+)	1275	WP_000704390.1	hydroxymethylglutaryl-CoA reductase, degradative	-

Sequence

Protein

• Length: 659 a.a.
• Molecular weight: 72288.81 Da
• Isoelectric Point: 9.0945

>NTDB_id=761462 OTB22_RS02435 WP_000614538.1 471665..473644(+) (stkP) [Streptococcus pneumoniae strain BC2]
MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIG
EEDGQQYLAMEYVAGLDLKRYIKEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQKPLPSVIAENPSVP
QALENVIIKATAKKLTNRYRSVSEMYVDLSSSLSYNRRNESKLIFDETSKADTKTLPKVSQSTLTSIPKVQAQTEHKSIK
NPSQAVTEETYQPQAPKKHRFKMRYLILLASLVLVAASLIWILSRTPATIAIPDVAGQTVAEAKATLKKANFEIGEEKTE
ASEKVEEGRIIRTDPGAGTGRKEGTKINLVVSSGKQSFQISNYVGRKSSDVIAELKEKKVPDNLIKIEEEESNESEAGTV
LKQSLPEGTTYDLSKATQIVLTVAKKATTIQLGNYIGRNSTEVISELKQKKVPENLIKIEEEESSESEPGTIMKQSPGAG
TTYDVSKPTQIVLTVAKKVTSVAMPSYIGSSLEFTKNNLIQIVGIKEANIEVVEVTTAPAGSAEGMVVEQSPRAGEKVDL
NKTRVKISIYKPKTTSATP

Nucleotide

• Length: 1980 bp

>NTDB_id=761462 OTB22_RS02435 WP_000614538.1 471665..473644(+) (stkP) [Streptococcus pneumoniae strain BC2]
ATGATCCAAATCGGCAAGATTTTTGCCGGACGCTATCGGATTGTCAAACAGATTGGTCGAGGAGGTATGGCGGATGTCTA
CCTAGCCAAAGACTTAATCTTAGATGGGGAAGAAGTGGCAGTGAAGGTTCTGAGGACCAACTACCAGACGGACCCGATAG
CTGTAGCTCGTTTTCAGCGTGAAGCGAGAGCTATGGCAGATCTAGACCATCCTCATATCGTTCGGATAACAGATATTGGC
GAGGAAGACGGTCAACAGTACCTAGCTATGGAGTATGTGGCTGGACTGGACCTCAAACGCTATATCAAGGAACATTATCC
TCTTTCTAATGAAGAAGCAGTCCGTATCATGGGACAAATTCTCTTGGCTATGCGCTTGGCCCATACTCGAGGAATTGTTC
ACAGGGACTTGAAACCTCAAAATATCCTCTTGACACCAGATGGGACTGCCAAGGTCACAGACTTTGGGATTGCTGTAGCC
TTTGCAGAGACAAGTCTGACCCAGACTAACTCGATGTTGGGCTCAGTTCATTACTTGTCACCAGAGCAGGCGCGTGGTTC
GAAGGCGACTGTGCAGAGTGATATCTATGCCATGGGGATTATTTTCTATGAGATGCTGACAGGCCATATCCCTTATGACG
GGGATAGCGCGGTGACCATTGCCCTCCAGCATTTCCAGAAACCCCTGCCGTCCGTTATTGCAGAAAATCCATCTGTACCT
CAGGCTTTAGAAAATGTTATTATCAAGGCAACTGCTAAAAAGTTGACCAATCGCTACCGCTCGGTTTCAGAGATGTATGT
GGACTTGTCTAGTAGCTTGTCCTACAATCGTAGAAATGAAAGTAAGTTAATCTTTGATGAAACGAGCAAGGCAGATACCA
AGACCTTGCCGAAGGTTTCTCAGAGTACCTTGACATCTATTCCTAAGGTTCAAGCGCAAACAGAACACAAATCAATCAAA
AACCCAAGCCAGGCTGTGACAGAGGAAACTTACCAACCACAAGCACCGAAAAAACATAGATTTAAGATGCGTTACCTGAT
TTTGTTGGCCAGCCTTGTATTGGTGGCAGCTTCTCTTATTTGGATACTATCCAGAACTCCTGCAACCATTGCCATTCCAG
ATGTGGCAGGTCAGACAGTTGCAGAGGCCAAGGCAACGCTCAAAAAAGCCAATTTTGAGATTGGTGAGGAGAAGACAGAG
GCTAGTGAAAAGGTGGAAGAAGGGCGGATTATCCGTACAGATCCTGGCGCTGGAACTGGTCGAAAAGAAGGAACGAAAAT
CAATTTGGTTGTCTCATCAGGCAAGCAATCTTTCCAAATTAGTAATTATGTCGGTCGGAAATCCTCTGATGTCATTGCGG
AATTAAAAGAGAAAAAAGTTCCAGATAATTTGATTAAAATTGAGGAAGAAGAGTCGAATGAGAGTGAGGCTGGAACGGTC
CTGAAGCAAAGTCTACCAGAAGGTACGACCTATGACTTGAGCAAGGCAACTCAAATTGTTTTGACAGTAGCTAAAAAAGC
TACGACGATTCAATTAGGGAACTATATTGGACGGAACTCTACAGAAGTAATCTCAGAACTCAAGCAGAAGAAGGTTCCTG
AGAATTTGATTAAGATAGAGGAAGAAGAGTCCAGCGAAAGCGAACCAGGAACGATTATGAAACAAAGTCCAGGTGCCGGA
ACGACTTATGATGTGAGTAAACCTACTCAAATTGTCTTGACAGTAGCTAAAAAAGTTACAAGTGTTGCCATGCCGAGTTA
CATTGGTTCTAGCTTGGAGTTTACTAAGAACAATTTGATTCAAATTGTTGGGATTAAGGAAGCTAATATAGAAGTTGTAG
AAGTGACGACAGCGCCTGCAGGTAGTGCAGAAGGCATGGTTGTTGAACAAAGTCCTAGAGCAGGTGAAAAGGTAGACCTC
AATAAGACTAGAGTCAAGATTTCAATCTACAAACCTAAAACAACTTCAGCTACTCCTTAA

Domains

Predicted by InterproScan.

• Protein kinase domain (Pkinase) (12-227)

• PASTA domain (PASTA) (440-505)

• PASTA domain (PASTA) (582-651)

• PASTA domain (PASTA) (513-577)

• PASTA domain (PASTA) (371-432)

3D structure

• AlphaFold DB: A0A0B7L145

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
stkP	Streptococcus pneumoniae TIGR4	100	100	1
stkP	Streptococcus pneumoniae D39	99.545	100	0.995
stkP	Streptococcus pneumoniae R6	99.545	100	0.995
stkP	Streptococcus pneumoniae Rx1	99.393	100	0.994
pknB	Streptococcus mutans UA159	52.65	88.771	0.467
stkP/pknB	Streptococcus salivarius strain HSISS4	51.807	88.164	0.457