Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   OTB22_RS00200 Genome accession   NZ_CP113267
Coordinates   34766..36919 (+) Length   717 a.a.
NCBI ID   WP_268217970.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain BC2     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 29766..41919
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OTB22_RS00165 (OTB22_00165) - 30117..31286 (+) 1170 WP_000366342.1 pyridoxal phosphate-dependent aminotransferase -
  OTB22_RS00170 (OTB22_00170) recO 31283..32053 (+) 771 WP_000616164.1 DNA repair protein RecO -
  OTB22_RS00175 (OTB22_00175) plsX 32050..33042 (+) 993 WP_000717458.1 phosphate acyltransferase PlsX -
  OTB22_RS00180 (OTB22_00180) - 33048..33281 (+) 234 WP_000136447.1 acyl carrier protein -
  OTB22_RS00185 (OTB22_00185) - 33318..33618 (+) 301 Protein_29 transposase family protein -
  OTB22_RS00190 (OTB22_00190) blpU 33821..34051 (+) 231 WP_001093075.1 bacteriocin-like peptide BlpU -
  OTB22_RS00195 (OTB22_00195) - 34054..34179 (+) 126 WP_000346297.1 PncF family bacteriocin immunity protein -
  OTB22_RS00200 (OTB22_00200) comA 34766..36919 (+) 2154 WP_268217970.1 peptide cleavage/export ABC transporter ComA Regulator
  OTB22_RS00205 (OTB22_00205) comB 36932..38281 (+) 1350 WP_000801620.1 competence pheromone export protein ComB Regulator
  OTB22_RS00210 (OTB22_00210) purC 38451..39158 (+) 708 WP_000043300.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  OTB22_RS11015 - 39169..39303 (+) 135 WP_000429437.1 hypothetical protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80368.41 Da        Isoelectric Point: 6.3370

>NTDB_id=761457 OTB22_RS00200 WP_268217970.1 34766..36919(+) (comA) [Streptococcus pneumoniae strain BC2]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPI
LVKQRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAALSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGEMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHAELLAQGGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=761457 OTB22_RS00200 WP_268217970.1 34766..36919(+) (comA) [Streptococcus pneumoniae strain BC2]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGCTTTGAGACACGAGCTATCAAGGCGGATATGACGCTTTTTGATTTGCCCGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGACAG
CATTCATATTGCCGATCCAGATCCTGGGGTGAAATTGACCAAACTGCCACGTGAGCGTTTTGAGGAAGAATGGACAGGAG
TGACTCTGTTTATGGCACCTAGTCCAGACTACAAGCCTCATAAGGATCAAAAGAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCTTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACGTTGGGGATTATTTCTATTGGGCTAGTCA
TCGTCTACATCCTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTCCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTC
TCGTTTTACAGATGCTAACAGTATCATCGATGCGCTGGCTTCGACCATCCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCGCTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCATTTGAAAAGATGAATCGGGACACCATGGAAGCCAATGCGGCTCTGTCTTCTTCTAT
CATTGAGGACATCAATGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTGCTTAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGAGATGACTTTCAAGCAGGTTCATTACAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTAACCGT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACTTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTACATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGATATCGAGCGCATGCCACTGAATTATCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCTTTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACTAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTCGATAATCTCATGGCTTT
GGACAAGACCTTGATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGGACAGAGAAGGTAGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGAGTTGCTTGCACAGGGTGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(170-438)

ABC transporter (ABC_tran)

(500-650)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus pneumoniae Rx1

99.163

100

0.992
  comA Streptococcus pneumoniae D39

99.163

100

0.992
  comA Streptococcus pneumoniae R6

99.163

100

0.992
  comA Streptococcus pneumoniae TIGR4

98.745

100

0.987
  comA Streptococcus mitis SK321

98.466

100

0.985
  comA Streptococcus mitis NCTC 12261

98.466

100

0.985
  comA Streptococcus gordonii str. Challis substr. CH1

80.753

100

0.808
  comA/nlmT Streptococcus mutans UA159

64.854

100

0.649