Detailed information NTG0760384

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: OTU45_RS12025
• Genome accession: NZ_CP113114
• Coordinates: 613994..614581 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain NP1
• Function: transport of ComC (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	612382..618121	613994..614581	within	0

Gene organization within MGE regions

Location: 612382..618121

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OTU45_RS03065 (OTU45_03065)	-	612382..613335 (-)	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-
OTU45_RS12020	comA/nlmT	613588..614049 (-)	462	WP_309543754.1	ABC transporter transmembrane domain-containing protein	Regulator
OTU45_RS12025	comA/nlmT	613994..614581 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
OTU45_RS03075 (OTU45_03075)	blpI	614895..615092 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
OTU45_RS03080 (OTU45_03080)	blpJ	615559..615828 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
OTU45_RS03085 (OTU45_03085)	blpU	615897..616127 (+)	231	WP_000379967.1	bacteriocin-like peptide BlpU	-
OTU45_RS03090 (OTU45_03090)	-	616130..616249 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
OTU45_RS03095 (OTU45_03095)	-	616548..616712 (+)	165	WP_000727118.1	hypothetical protein	-
OTU45_RS03100 (OTU45_03100)	-	616709..617113 (+)	405	WP_000846944.1	hypothetical protein	-
OTU45_RS03105 (OTU45_03105)	-	617316..618121 (+)	806	Protein_609	IS5 family transposase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=760384 OTU45_RS12025 WP_000205166.1 613994..614581(-) (comA/nlmT) [Streptococcus pneumoniae strain NP1]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=760384 OTU45_RS12025 WP_000205166.1 613994..614581(-) (comA/nlmT) [Streptococcus pneumoniae strain NP1]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATCGGTGGTT
CTTATTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497