Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGD/cglD   Type   Machinery gene
Locus tag   OTU45_RS10805 Genome accession   NZ_CP113114
Coordinates   2095272..2095676 (-) Length   134 a.a.
NCBI ID   WP_000588013.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain NP1     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 2096426..2134772 2095272..2095676 flank 750


Gene organization within MGE regions


Location: 2095272..2134772
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OTU45_RS10805 (OTU45_10805) comGD/cglD 2095272..2095676 (-) 405 WP_000588013.1 competence type IV pilus minor pilin ComGD Machinery gene
  OTU45_RS10810 (OTU45_10810) comGC/cglC 2095669..2095935 (-) 267 WP_050073122.1 competence type IV pilus major pilin ComGC Machinery gene
  OTU45_RS10815 (OTU45_10815) - 2095937..2096194 (-) 258 WP_000698513.1 hypothetical protein -
  OTU45_RS10820 (OTU45_10820) lytA 2096426..2097382 (-) 957 WP_054436120.1 N-acetylmuramoyl-L-alanine amidase LytA -
  OTU45_RS10825 (OTU45_10825) - 2097382..2097717 (-) 336 WP_001186204.1 phage holin -
  OTU45_RS10830 (OTU45_10830) - 2097721..2098020 (-) 300 WP_001811580.1 hypothetical protein -
  OTU45_RS10835 (OTU45_10835) - 2098030..2098380 (-) 351 WP_054368148.1 hypothetical protein -
  OTU45_RS10840 (OTU45_10840) - 2098383..2098586 (-) 204 WP_001091107.1 hypothetical protein -
  OTU45_RS10845 (OTU45_10845) - 2098567..2098683 (-) 117 WP_001063632.1 hypothetical protein -
  OTU45_RS10850 (OTU45_10850) - 2098680..2106629 (-) 7950 WP_267747982.1 phage tail spike protein -
  OTU45_RS10855 (OTU45_10855) - 2106626..2107324 (-) 699 WP_000499607.1 adenylosuccinate synthetase -
  OTU45_RS10860 (OTU45_10860) - 2107324..2109789 (-) 2466 WP_050228208.1 hypothetical protein -
  OTU45_RS10865 (OTU45_10865) - 2109789..2110175 (-) 387 WP_000560880.1 DUF5361 domain-containing protein -
  OTU45_RS10870 (OTU45_10870) - 2110187..2110462 (-) 276 WP_000391234.1 hypothetical protein -
  OTU45_RS10875 (OTU45_10875) - 2110468..2111025 (-) 558 WP_050254374.1 hypothetical protein -
  OTU45_RS10880 (OTU45_10880) - 2111092..2111427 (-) 336 WP_000571659.1 hypothetical protein -
  OTU45_RS10885 (OTU45_10885) - 2111424..2111660 (-) 237 WP_000069060.1 hypothetical protein -
  OTU45_RS10890 (OTU45_10890) - 2111653..2111991 (-) 339 WP_000221695.1 hypothetical protein -
  OTU45_RS10895 (OTU45_10895) - 2111936..2112376 (-) 441 WP_267748001.1 phage Gp19/Gp15/Gp42 family protein -
  OTU45_RS10900 (OTU45_10900) - 2112380..2112592 (-) 213 WP_001240369.1 HeH/LEM domain-containing protein -
  OTU45_RS10905 (OTU45_10905) - 2112598..2113497 (-) 900 WP_267748004.1 phage major capsid protein -
  OTU45_RS10910 (OTU45_10910) - 2113503..2113967 (-) 465 WP_050254365.1 DUF4355 domain-containing protein -
  OTU45_RS10915 (OTU45_10915) - 2114049..2115461 (-) 1413 WP_267748008.1 DEAD/DEAH box helicase family protein -
  OTU45_RS10920 (OTU45_10920) - 2115512..2115742 (-) 231 WP_050254363.1 hypothetical protein -
  OTU45_RS10925 (OTU45_10925) - 2115792..2116019 (-) 228 WP_050254362.1 hypothetical protein -
  OTU45_RS10930 (OTU45_10930) - 2116006..2117241 (-) 1236 WP_267748011.1 hypothetical protein -
  OTU45_RS10935 (OTU45_10935) - 2117195..2118499 (-) 1305 WP_267748013.1 hypothetical protein -
  OTU45_RS10940 (OTU45_10940) - 2118636..2118980 (-) 345 WP_001095652.1 HNH endonuclease -
  OTU45_RS10945 (OTU45_10945) - 2119214..2119780 (-) 567 WP_061634575.1 site-specific integrase -
  OTU45_RS10950 (OTU45_10950) - 2120070..2120498 (-) 429 WP_050216380.1 ArpU family phage packaging/lysis transcriptional regulator -
  OTU45_RS10955 (OTU45_10955) - 2120511..2120699 (-) 189 WP_050240803.1 multiprotein-bridging factor 1 family protein -
  OTU45_RS10960 (OTU45_10960) - 2120692..2120868 (-) 177 WP_000005959.1 hypothetical protein -
  OTU45_RS10965 (OTU45_10965) - 2120861..2121097 (-) 237 WP_001067627.1 DUF3310 domain-containing protein -
  OTU45_RS10970 (OTU45_10970) - 2121113..2121634 (-) 522 WP_050254359.1 YopX family protein -
  OTU45_RS10975 (OTU45_10975) - 2121646..2121924 (-) 279 WP_001813036.1 hypothetical protein -
  OTU45_RS10980 (OTU45_10980) - 2122006..2122292 (-) 287 Protein_2147 hypothetical protein -
  OTU45_RS10985 (OTU45_10985) - 2122276..2122878 (-) 603 WP_050254358.1 DUF1642 domain-containing protein -
  OTU45_RS10990 (OTU45_10990) - 2122871..2123371 (-) 501 WP_001041165.1 DUF1642 domain-containing protein -
  OTU45_RS10995 (OTU45_10995) - 2123373..2123690 (-) 318 WP_180372348.1 hypothetical protein -
  OTU45_RS11000 (OTU45_11000) - 2123662..2123871 (-) 210 WP_000872731.1 hypothetical protein -
  OTU45_RS11005 (OTU45_11005) - 2123858..2124025 (-) 168 WP_267748031.1 hypothetical protein -
  OTU45_RS11010 (OTU45_11010) - 2124116..2124421 (-) 306 WP_001097109.1 hypothetical protein -
  OTU45_RS11015 (OTU45_11015) - 2124421..2124639 (-) 219 WP_000891962.1 hypothetical protein -
  OTU45_RS11020 (OTU45_11020) - 2124639..2124833 (-) 195 WP_000470303.1 hypothetical protein -
  OTU45_RS11025 (OTU45_11025) - 2124848..2125618 (-) 771 WP_000228210.1 ATP-binding protein -
  OTU45_RS11030 (OTU45_11030) - 2125612..2125770 (-) 159 WP_000511761.1 hypothetical protein -
  OTU45_RS11035 (OTU45_11035) - 2125758..2126564 (-) 807 WP_267748048.1 phage replisome organizer N-terminal domain-containing protein -
  OTU45_RS11040 (OTU45_11040) - 2126557..2126853 (-) 297 WP_000391807.1 hypothetical protein -
  OTU45_RS11045 (OTU45_11045) - 2126869..2127189 (-) 321 WP_000462831.1 hypothetical protein -
  OTU45_RS11050 (OTU45_11050) - 2127275..2127397 (-) 123 Protein_2161 DNA-binding protein -
  OTU45_RS11055 (OTU45_11055) - 2127401..2127559 (-) 159 WP_180384356.1 BOW99_gp33 family protein -
  OTU45_RS11060 (OTU45_11060) - 2127631..2128347 (-) 717 WP_001004043.1 phage antirepressor KilAC domain-containing protein -
  OTU45_RS11065 (OTU45_11065) - 2128371..2128574 (-) 204 WP_001247820.1 hypothetical protein -
  OTU45_RS11070 (OTU45_11070) - 2129228..2129416 (-) 189 WP_001161207.1 helix-turn-helix transcriptional regulator -
  OTU45_RS11075 (OTU45_11075) - 2129608..2129898 (-) 291 WP_001815531.1 hypothetical protein -
  OTU45_RS11080 (OTU45_11080) - 2130097..2130546 (+) 450 WP_001058908.1 hypothetical protein -
  OTU45_RS11085 (OTU45_11085) - 2130537..2130704 (-) 168 WP_267748061.1 hypothetical protein -
  OTU45_RS11090 (OTU45_11090) - 2130779..2131054 (-) 276 WP_001094375.1 hypothetical protein -
  OTU45_RS11095 (OTU45_11095) - 2131209..2131997 (+) 789 WP_050116194.1 helix-turn-helix domain-containing protein -
  OTU45_RS11100 (OTU45_11100) - 2131999..2132199 (+) 201 WP_000064302.1 hypothetical protein -
  OTU45_RS11105 (OTU45_11105) - 2132373..2133818 (+) 1446 WP_267748066.1 recombinase family protein -

Sequence

Protein


Download         Length: 134 a.a.        Molecular weight: 14665.85 Da        Isoelectric Point: 10.2164

>NTDB_id=760374 OTU45_RS10805 WP_000588013.1 2095272..2095676(-) (comGD/cglD) [Streptococcus pneumoniae strain NP1]
MIKAFTMLESLLVLGLVSILALGLSGSVQSTFAAVEEQIFFMEFEELYRETQKRSVASQQKTNLNLDGQTLSNGSQKLTV
PKGIQAPSGQSITFDRAGGNSSLAKVEFQTSKGAIRYQLYLGNGKIKRIKETKN

Nucleotide


Download         Length: 405 bp        

>NTDB_id=760374 OTU45_RS10805 WP_000588013.1 2095272..2095676(-) (comGD/cglD) [Streptococcus pneumoniae strain NP1]
ATGATTAAGGCCTTTACCATGCTGGAAAGTCTCTTGGTTTTGGGTCTTGTGAGTATCCTTGCCTTGGGCTTGTCCGGCTC
TGTTCAGTCCACTTTTGCGGCGGTAGAGGAACAGATTTTCTTTATGGAGTTTGAAGAACTCTATCGGGAAACCCAAAAAC
GCAGTGTAGCCAGTCAGCAAAAGACTAATCTAAATTTAGATGGGCAGACGCTTAGCAATGGCAGTCAAAAGTTGACAGTT
CCTAAAGGAATTCAGGCACCATCAGGCCAAAGTATTACATTTGACCGAGCTGGGGGCAATTCGTCCCTGGCTAAGGTTGA
ATTTCAGACCAGTAAAGGAGCGATTCGCTATCAATTATATCTAGGAAATGGAAAAATTAAACGCATTAAGGAAACAAAAA
ATTAG

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGD/cglD Streptococcus pneumoniae TIGR4

97.761

100

0.978
  comGD/cglD Streptococcus pneumoniae Rx1

97.015

100

0.97
  comGD/cglD Streptococcus pneumoniae D39

97.015

100

0.97
  comGD/cglD Streptococcus pneumoniae R6

97.015

100

0.97
  comGD/cglD Streptococcus mitis SK321

96.269

100

0.963
  comGD/cglD Streptococcus mitis NCTC 12261

96.992

99.254

0.963
  comYD Streptococcus gordonii str. Challis substr. CH1

58.268

94.776

0.552
  comYD Streptococcus mutans UA140

49.219

95.522

0.47
  comYD Streptococcus mutans UA159

49.219

95.522

0.47