Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEC/celB   Type   Machinery gene
Locus tag   OTU45_RS04980 Genome accession   NZ_CP113114
Coordinates   990863..993103 (+) Length   746 a.a.
NCBI ID   WP_050118046.1    Uniprot ID   A0A4F2DX44
Organism   Streptococcus pneumoniae strain NP1     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 985863..998103
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OTU45_RS04950 (OTU45_04950) - 986014..986982 (+) 969 WP_000658183.1 PhoH family protein -
  OTU45_RS04955 (OTU45_04955) - 987175..987675 (+) 501 WP_050118047.1 GNAT family N-acetyltransferase -
  OTU45_RS04960 (OTU45_04960) - 987678..988003 (+) 326 Protein_980 TfoX/Sxy family protein -
  OTU45_RS04965 (OTU45_04965) ald 988304..989415 (-) 1112 Protein_981 alanine dehydrogenase -
  OTU45_RS04970 (OTU45_04970) - 989592..990161 (+) 570 WP_000443739.1 GNAT family N-acetyltransferase -
  OTU45_RS04975 (OTU45_04975) comEA/celA/cilE 990229..990879 (+) 651 WP_001866227.1 helix-hairpin-helix domain-containing protein Machinery gene
  OTU45_RS04980 (OTU45_04980) comEC/celB 990863..993103 (+) 2241 WP_050118046.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  OTU45_RS04985 (OTU45_04985) - 993245..993469 (+) 225 WP_050118045.1 hypothetical protein -
  OTU45_RS04990 (OTU45_04990) - 993501..994088 (+) 588 WP_000933542.1 ATP-binding cassette domain-containing protein -
  OTU45_RS04995 (OTU45_04995) - 994092..995273 (+) 1182 WP_050118044.1 hypothetical protein -
  OTU45_RS05000 (OTU45_05000) infC 995580..996110 (+) 531 WP_000848180.1 translation initiation factor IF-3 -
  OTU45_RS05005 (OTU45_05005) rpmI 996143..996343 (+) 201 WP_001125943.1 50S ribosomal protein L35 -
  OTU45_RS05010 (OTU45_05010) rplT 996395..996754 (+) 360 WP_000124836.1 50S ribosomal protein L20 -
  OTU45_RS05015 (OTU45_05015) - 996812..997192 (+) 381 WP_000157154.1 VOC family protein -

Sequence

Protein


Download         Length: 746 a.a.        Molecular weight: 84617.97 Da        Isoelectric Point: 8.7661

>NTDB_id=760333 OTU45_RS04980 WP_050118046.1 990863..993103(+) (comEC/celB) [Streptococcus pneumoniae strain NP1]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSVSYFALLGFVFLLVCLFIQFPWKSAGKVLVICGVFGFWFLFQTWQQSQVSQN
LVDSVERVRILPDTIKVNGDSLSFRGKSDGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFDYQGY
LKTQGIYQTLNIKRIQSLQKVGSWDIGENLSSLRRKAVVWIKMHFPDPMRNYMTGLLLGYLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLQLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVTSRPLVFGQPNAWFLILLLISLALVYDLRKNIKKLTVLCLLITGLFLLTK
HPLENEITMLDVGQGESIFLWDITGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
EHVGDLSEVTKAFHVGEILVSKDSLKQKEFVAELQATQTKVRSMTVGENLPIFGSQLEVLSPRKMGDGGHDDTLVLYGKF
LDKQFLFTGNLEEKGEKDLLKHYPDLEVDVLKAGQHGSKKSSSSAFLEKLKPELTLISVGKNNRTKLPHQETLTRLEGIN
SQVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide


Download         Length: 2241 bp        

>NTDB_id=760333 OTU45_RS04980 WP_050118046.1 990863..993103(+) (comEC/celB) [Streptococcus pneumoniae strain NP1]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTGTTACTATGGCTTTACTACGCCATTTT
CTCAGTATCCTATTTTGCTTTGTTGGGTTTTGTTTTTCTGCTAGTCTGCCTCTTTATCCAATTTCCTTGGAAATCAGCAG
GTAAAGTTCTAGTGATTTGTGGAGTCTTTGGCTTCTGGTTTCTGTTTCAAACTTGGCAACAGAGTCAAGTGAGTCAAAAT
TTGGTGGATTCTGTTGAAAGGGTACGGATTTTACCAGACACTATTAAGGTCAACGGTGACAGTCTGTCCTTTCGTGGTAA
GTCTGATGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACTGACC
TTCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTGACTACCAAGGCTAT
CTGAAGACTCAGGGAATTTACCAGACACTCAATATTAAAAGAATCCAGTCACTCCAAAAGGTTGGTAGTTGGGATATAGG
TGAAAACCTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGATGCACTTCCCAGACCCTATGCGCAATTACATGA
CAGGACTTTTGCTGGGATATCTGGACACCGACTTTGAGGAGATGAATGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCAATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTAACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GGAGGGGCTCAAGGCTGTTGCTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTGGAGGGCATTATTCGCTTGGT
GTCACAGGTGACAAGTAGACCTCTGGTCTTTGGACAACCCAATGCATGGTTTTTAATCCTATTGTTAATTTCCTTGGCTT
TGGTCTATGATTTGAGAAAAAACATTAAAAAGCTAACGGTATTGTGCTTATTGATTACAGGGCTCTTTCTCCTGACCAAG
CATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTATGGGATATAACTGGGAAAAC
CATTCTCATAGATGTCGGTGGCAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CCCAGCGAACCTTGATTCCCTATCTCAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAGCATGTTGGAGATTTGTCAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTCTAGTATCAAAAGACAGTCTGAAACA
GAAGGAATTTGTGGCAGAACTACAGGCGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGAACTTGCCCATTTTTG
GAAGTCAGTTAGAAGTTCTATCTCCAAGGAAAATGGGAGATGGAGGACACGATGATACCCTAGTTCTGTATGGGAAATTC
TTGGATAAGCAATTTCTCTTCACGGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGCACTATCCTGACCTCGA
GGTGGATGTCTTGAAAGCTGGCCAACATGGCTCTAAAAAATCATCAAGTTCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAATAATCGAACGAAATTACCACATCAAGAAACCTTGACTCGACTGGAAGGTATCAAT
AGTCAAGTTTACCGAACTGACCAGCAAGGAGCTATACGCTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

Metallo-beta-lactamase superfamily (Lactamase_B)

(492-698)

Domain of unknown function (DUF4131) (DUF4131)

(30-176)

Competence protein (Competence)

(216-458)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4F2DX44

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEC/celB Streptococcus pneumoniae Rx1

95.174

100

0.952
  comEC/celB Streptococcus pneumoniae D39

95.174

100

0.952
  comEC/celB Streptococcus pneumoniae R6

95.174

100

0.952
  comEC/celB Streptococcus pneumoniae TIGR4

94.772

100

0.948
  comEC/celB Streptococcus mitis NCTC 12261

91.678

99.866

0.916
  comEC/celB Streptococcus mitis SK321

91.287

100

0.913
  comEC Lactococcus lactis subsp. cremoris KW2

44.399

99.33

0.441