Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   UKS_RS03485 Genome accession   NZ_AP021887
Coordinates   685056..685793 (+) Length   245 a.a.
NCBI ID   WP_049495175.1    Uniprot ID   A0A6H3S4Q4
Organism   Streptococcus sp. 116-D4     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 680056..690793
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  UKS_RS03465 (UKS_06360) - 680250..681353 (+) 1104 WP_156011829.1 glycosyltransferase -
  UKS_RS03470 (UKS_06370) - 681355..682341 (+) 987 WP_156011830.1 glycosyltransferase family 2 protein -
  UKS_RS03475 (UKS_06380) - 682357..683826 (+) 1470 WP_156011831.1 O-antigen polysaccharide polymerase Wzy family protein -
  UKS_RS03480 (UKS_06390) - 683819..684853 (+) 1035 WP_049495172.1 hypothetical protein -
  UKS_RS03485 (UKS_06400) mecA 685056..685793 (+) 738 WP_049495175.1 adaptor protein MecA Regulator
  UKS_RS03490 (UKS_06410) - 685945..687231 (+) 1287 WP_156011832.1 homoserine dehydrogenase -
  UKS_RS03495 (UKS_06420) thrB 687233..688102 (+) 870 WP_156011833.1 homoserine kinase -
  UKS_RS03500 (UKS_06430) msrB 688360..689298 (+) 939 WP_156011834.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28665.50 Da        Isoelectric Point: 4.0228

>NTDB_id=75347 UKS_RS03485 WP_049495175.1 685056..685793(+) (mecA) [Streptococcus sp. 116-D4]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPESFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQDEQEIESKKEPYIYYILSFE
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMNHDAVLN
LQKIR

Nucleotide


Download         Length: 738 bp        

>NTDB_id=75347 UKS_RS03485 WP_049495175.1 685056..685793(+) (mecA) [Streptococcus sp. 116-D4]
ATGAAAATGAAACAAATCAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGAGGCATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTAGATGAGTTAGAGATGCCGGAGAGTT
TTTTGGATACAGGCATGTTGAGCTTCCGTGTAACTCCAAAACCTGATAAGGTCGATGTCTTTGTAACCAAATCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTACCAGATATGGAAGAATTAGCTCAAATGTCGCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGTATCGCGGACAAGACTAAGGATGATATTGAAGCGATTCAATCTCTAGAGCAAGTCGAAGCCA
AGGAAGAAGAGCAAGAGCAGGATGAACAAGAAATTGAAAGTAAGAAAGAGCCTTACATCTATTACATCCTTTCTTTTGAA
AAATTAGCTGACTTGGTGGCTTTTGCCAAGACAGTTACTTTTGAGATGGAAACTTCTGAACTCTACAAGATGAATGAGCG
CTATTATTTGACTATTTTAGTAGATATTGAAAATCATCCAAGTCCGTATCCGGCTTGGTTGTTGGCCCGTATGCGGGAGT
TTGCAGACGATAGTGACATCAGTCGTTCAGTCTTGCAAGAGTATGGTCAAGTCTTGATGAATCACGATGCCGTACTCAAT
CTGCAAAAGATTAGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6H3S4Q4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

97.541

99.592

0.971
  mecA Streptococcus pneumoniae D39

97.541

99.592

0.971
  mecA Streptococcus pneumoniae R6

97.541

99.592

0.971
  mecA Streptococcus pneumoniae TIGR4

97.131

99.592

0.967
  mecA Streptococcus mutans UA159

48.361

99.592

0.482
  mecA Streptococcus thermophilus LMD-9

45.635

100

0.469
  mecA Streptococcus thermophilus LMG 18311

45.238

100

0.465

Multiple sequence alignment